Hops Strobiles Extract
Also known as: Humulus lupulus L., Hops, Hop Strobiles, Humulus lupulus
Overview
Hops, scientifically known as *Humulus lupulus*, are the flowers of the hop plant, commonly used in brewing beer. Hops strobiles extract is derived from these flowers and is utilized as a dietary supplement. Traditionally, it has been used to alleviate sleep disturbances, reduce anxiety, and manage menopausal symptoms. The extract contains bioactive compounds such as xanthohumol and isoxanthohumol, which are believed to contribute to its potential health benefits. Research on hops extract is considered to be at a moderate level, with some clinical trials indicating promising results, although more systematic reviews are needed to confirm these findings. The quality of available evidence is variable, highlighting the need for more rigorous research to fully understand its effects and safety profile. Hops extracts are available in various forms, including capsules, tablets, and liquid extracts.
Benefits
Hops extract has demonstrated potential in reducing menopausal symptoms, particularly hot flashes. Studies have shown a significant reduction in hot flashes in groups using hops compared to control groups. While evidence is less robust, there are indications of benefits for improving sleep quality and reducing anxiety. These effects are potentially beneficial for postmenopausal women experiencing vasomotor symptoms. The effect size for reducing hot flashes is notable, but further research is needed to substantiate other benefits. Some studies suggest that benefits may be observed within a few weeks of consistent use. Further research is needed to confirm these findings and establish optimal dosages for different conditions.
How it works
Hops extract is believed to exert its effects through several mechanisms. Its phytoestrogenic properties may contribute to the relief of menopausal symptoms by mimicking estrogen in the body. Xanthohumol, a key component, possesses antioxidant and anti-inflammatory properties that may also play a role. The extract interacts with the endocrine system, potentially binding to estrogen receptors, although the precise mechanisms are not fully elucidated. Formulations like hydroxypropyl-β-cyclodextrin can improve the absorption and bioavailability of hops compounds, enhancing their effectiveness. Further research is needed to fully understand the complex interactions and pathways involved.
Side effects
Hops extract is generally considered safe when used appropriately, but some side effects have been reported. Common side effects, although not well-documented, may include gastrointestinal upset. Less common side effects include the potential for allergic reactions. Rare side effects are not well-documented. Hops may interact with sedatives or estrogen-sensitive medications, potentially enhancing their effects. It is contraindicated in pregnancy and breastfeeding due to a lack of safety data. Caution is advised for individuals with hormone-sensitive conditions, such as estrogen-dependent cancers. It is important to consult with a healthcare provider before using hops extract, especially if you have any underlying health conditions or are taking other medications.
Dosage
The minimum effective dose of hops extract is not well-established, but typical dosages range from 100 to 500 mg per day. Optimal dosage ranges vary depending on the specific formulation and intended use. The maximum safe dose is not clearly defined, but high doses may increase the risk of side effects. For sleep aid, it is best taken before bedtime. Extracts may be more bioavailable than whole plant material. Certain formulations, such as those containing cyclodextrins, can enhance absorption. It is important to start with a low dose and gradually increase as needed, while monitoring for any adverse effects. Consult with a healthcare provider to determine the appropriate dosage for your individual needs.
FAQs
Can hops extract interact with other medications?
Yes, hops extract may interact with sedatives or estrogen-sensitive medications, potentially enhancing their effects. Consult with a healthcare provider before use if you are taking other medications.
Is hops extract safe for everyone?
Generally safe, but caution is advised for individuals with hormone-sensitive conditions, and it is contraindicated during pregnancy and breastfeeding due to a lack of safety data.
When is the best time to take hops extract?
For sleep benefits, it is best taken before bedtime. Follow the specific recommendations on the product label or as advised by your healthcare provider.
What are the expected results from taking hops extract?
Hops extract may help reduce menopausal symptoms, such as hot flashes, and improve sleep quality. Individual results may vary, and it is not a substitute for medical treatment for severe conditions.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/27105715/ – This systematic review and meta-analysis examined the effects of hops on menopausal symptoms in postmenopausal women. The study found that hops may reduce menopausal symptoms, particularly hot flashes, but noted limitations due to the variability in study designs and the need for more robust methodologies. The quality of the evidence was assessed as moderate.
- https://journals.sagepub.com/doi/full/10.1177/10915818231221796 – This study investigated the effects of hops extracts on weight gain and metabolic markers in male mice fed high-fat diets over 20 weeks. The findings indicated that hops extracts reduced weight gain and improved metabolic markers. However, the study's limitations include that it was conducted on an animal model, making it not directly applicable to humans.
- https://pubs.acs.org/doi/10.1021/acs.chemrestox.8b00345 – This in vitro study assessed the mutagenicity and safety of hops extracts for cosmetic use. The results indicated that hops extracts are not mutagenic and are safe for cosmetic applications. The limitation is that in vitro findings may not fully translate to human safety, and clinical relevance is limited.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10525257/ – This study investigates the use of Humulus lupulus extract with hydroxypropyl-β-cyclodextrin for improved bioavailability. The study highlights the potential of this formulation to enhance the absorption of hops compounds, which could lead to more effective therapeutic outcomes. This is important for improving the efficacy of hops-based supplements.
- https://www.cir-safety.org/sites/default/files/HumLup042017TR.pdf – This report provides a safety assessment of Humulus lupulus (hops) extract for cosmetic use. The assessment concludes that hops extract is safe for use in cosmetics under the specified conditions. This report contributes to the overall safety profile of hops extract, although it is specific to cosmetic applications.