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MenaQ7

Also known as: Menaquinone-7, MK-7, Vitamin K2, MenaQ7

Overview

Menaquinone-7 (MK-7), a form of vitamin K2, is a fat-soluble vitamin naturally produced by bacteria and found in fermented foods like natto. It is commercially available as MenaQ7, produced through bacterial fermentation. MK-7 plays a crucial role in cardiovascular and bone health by activating proteins involved in calcium regulation and bone mineralization. Known for its high purity and all-trans configuration, which ensures biological activity, MK-7 is used as a dietary supplement to support bone strength, reduce arterial stiffness, and improve overall vitamin K status. Research suggests that MK-7 supplementation can significantly reduce levels of dp-ucMGP, a marker of vitamin K deficiency, particularly in postmenopausal women. While research is ongoing, current evidence supports its benefits for specific populations and health outcomes.

Benefits

Menaquinone-7 (MK-7) supplementation has demonstrated benefits primarily in cardiovascular and bone health. Studies show that MK-7 can reduce arterial stiffness and decrease dp-ucMGP levels, a marker of vitamin K status. A three-year study involving postmenopausal women found a 50% reduction in dp-ucMGP levels with a daily intake of 180 µg of MK-7. MK-7 may also improve bone strength and density, particularly in postmenopausal women. Emerging research suggests potential benefits in reducing vascular calcification, though further studies are needed to confirm these findings. These benefits are typically observed within several months of consistent supplementation, highlighting the importance of long-term use for optimal results.

How it works

Menaquinone-7 (MK-7) functions by activating vitamin K-dependent proteins, such as osteocalcin and matrix Gla protein, which are crucial for bone and vascular health. Osteocalcin, when activated, promotes bone mineralization, while matrix Gla protein inhibits calcium deposition in arteries, preventing vascular calcification. MK-7 is well-absorbed and remains detectable in the bloodstream for up to 48 hours after intake, allowing for sustained activation of these proteins. This mechanism of action primarily affects the bone and cardiovascular systems, contributing to improved bone density and reduced arterial stiffness.

Side effects

Menaquinone-7 (MK-7) is generally considered safe with minimal side effects. Common side effects are rare, but some individuals may experience mild gastrointestinal disturbances. In rare cases, hypotension has been reported, possibly due to interactions with other medications. Individuals on anticoagulant therapy should consult a healthcare provider before using MK-7, as it can interact with these medications and affect blood clotting. Pregnant or breastfeeding women should also seek medical advice before starting MK-7 supplementation. Overall, MK-7 has a favorable safety profile when used as directed, but caution is advised for those with pre-existing conditions or taking specific medications.

Dosage

The minimum effective dose of Menaquinone-7 (MK-7) is typically around 180 µg per day. Optimal dosage ranges from 180 to 360 µg per day, although doses up to 360 µg per day are generally considered safe. There are no specific timing recommendations, and MK-7 can be taken with meals to enhance absorption, as it is a fat-soluble vitamin. Fermented forms like MenaQ7 are often preferred for their purity and efficacy. It is important to note that individuals on anticoagulant therapy should consult with a healthcare provider to determine a safe and appropriate dosage.

FAQs

What is the best form of Vitamin K2 to take?

MenaQ7, an all-trans form of MK-7, is often recommended due to its high purity and efficacy. Ensure the supplement specifies 'all-trans' on the label for optimal results.

Can I take MenaQ7 if I am on blood thinners?

Consult your healthcare provider before taking MenaQ7 if you are on anticoagulant therapy, as it can interact with these medications and affect blood clotting.

When is the best time to take MenaQ7?

MenaQ7 can be taken at any time of day, preferably with a meal containing fat to enhance absorption. Consistency is key for observing benefits over time.

How long does it take to see results from MenaQ7 supplementation?

Improvements in cardiovascular and bone health markers may be observed within several months of consistent MenaQ7 supplementation. Individual results may vary.

Is MenaQ7 the same as other Vitamin K2 supplements?

Not all vitamin K2 supplements are equally effective. MenaQ7 is specifically noted for its purity and efficacy due to its all-trans configuration and bacterial fermentation process.

Research Sources

https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Vitamin-K2.pdf – This resource from the Alzheimer's Drug Discovery Foundation provides an overview of Vitamin K2, including its potential benefits for cognitive health. It highlights the role of Vitamin K2 in activating proteins involved in bone and vascular health, which indirectly supports brain function by maintaining healthy blood vessels.
https://info.davincilabs.com/menaq7-guide – This guide offers comprehensive information about MenaQ7, a specific form of Vitamin K2. It details the benefits of MenaQ7 for bone and cardiovascular health, emphasizing its high purity and all-trans configuration, which ensures optimal biological activity. The guide also provides dosing recommendations and safety information.
https://menaq7.com/news/menaq7-1-year-cardio-study-benefits-in-men-woman/ – This article reports on a one-year study demonstrating the cardiovascular benefits of MenaQ7 in both men and women with poor vitamin K status. The study found that MenaQ7 supplementation improved vascular health, highlighting its potential to support cardiovascular function in individuals with vitamin K deficiency.
https://pubmed.ncbi.nlm.nih.gov/23062766/ – This study investigates the dose-dependent effects of Menaquinone-7 (MK-7) supplementation on vitamin K status. The research demonstrates that MK-7 supplementation dose-dependently decreases dp-ucMGP levels, indicating improved vitamin K status. The study's well-designed methodology and significant outcomes support the efficacy of MK-7 in enhancing vitamin K levels.
https://menaq7.com/news/study-says-menaq7-pure-k2-shown-to-protect-against-calcification/ – This news article discusses a study indicating that MenaQ7, a pure form of Vitamin K2, protects against calcification. The research suggests that MenaQ7 can help prevent calcium buildup in arteries, supporting cardiovascular health. The study highlights the potential of MenaQ7 in reducing vascular calcification.