Winged Treebine Extract
Also known as: Winged Treebine, Veldt Grape, Cissus, Cissus quadrangularis L., Cissus quadrangularis
Overview
Cissus quadrangularis L. is a medicinal plant native to Africa and Asia, characterized by its quadrangular stems. Traditionally, it has been employed in Ayurvedic and Unani medicine to address various health concerns, particularly for its potential to enhance bone health, accelerate fracture recovery, and support weight management. The plant contains a rich profile of phytochemicals, including flavonoids, triterpenoids, and steroids, which contribute to its pharmacological efficacy. Research has indicated its usefulness in managing specific health conditions, such as osteoporosis and metabolic disorders, though more rigorous clinical studies are required to validate its safety and broad-ranging effects. Cissus quadrangularis is commonly available as an extract in capsules, tablets, and powders.
Benefits
Cissus quadrangularis has shown several notable benefits: - **Bone Health**: Evidence suggests it may alleviate bone pain and assist in fracture healing, with particular efficacy noted for postmenopausal women at risk for bone loss. - **Weight Management**: Clinical meta-analysis indicates an average weight reduction of approximately -5.19 kg in participants taking Cissus supplements compared to placebo, marking its effectiveness for weight loss. - **Anti-inflammatory Actions**: The extract possesses anti-inflammatory properties, aiding in the management of inflammatory conditions. - **Anti-diabetic Effects**: Cissus quadrangularis has been associated with reduced glucose production and improved lipid profiles, indicating potential benefits for managing type 2 diabetes. Overall, the quality of evidence varies, with weight management and bone health likely indicating stronger support.
How it works
Cissus quadrangularis operates through various biological mechanisms. It primarily inhibits gluconeogenesis and lipogenesis, promoting better glucose control. Its anti-inflammatory properties stem from the suppression of NF-ΚB activation, leading to reduced markers of inflammation. The phytochemicals present in the plant target crucial molecular pathways that contribute to inflammation and metabolism, while also promoting recovery and strengthening within the skeletal system, ultimately improving bone health.
Side effects
Cissus quadrangularis is generally considered safe for use. Clinical trials have not revealed serious adverse effects, and the prevalence of common side effects is low (>5%). Some uncommon side effects have been noted but lack substantial documentation across studies (1-5% frequency). Rare adverse effects (<1%) have similarly not been reported. Caution is advisable for individuals taking diabetes or cholesterol medications, given limited data on potential interactions. Pregnant and nursing women are advised to abstain from its use until more safety data is available. Additionally, individuals with pre-existing health conditions should consult healthcare professionals before starting the supplement to mitigate risks.
Dosage
The recommended dosage for Cissus quadrangularis, depending on the condition being addressed, typically ranges from 500 mg to 3 grams per day. Clinical studies often demonstrate benefits at doses of 1-3 grams daily. While there is no established maximum dosage, up to 3 grams have been well tolerated without notable adverse effects. It is recommended to take the supplement with meals to optimize absorption. Cissus extracts are primarily available in capsule or tablet forms, and consistent use over weeks is important to observe cumulative benefits.
FAQs
Is Cissus quadrangularis safe?
Yes, Cissus quadrangularis is generally considered safe, but users should consult healthcare providers if taking other medications.
When is the best time to take Cissus quadrangularis?
It can be taken at any time, but taking it with meals may enhance absorption.
How long until I see results from Cissus quadrangularis?
Benefits typically manifest over several weeks to months, depending on the condition treated.
Can Cissus quadrangularis help with weight loss?
Yes, studies indicate it can aid in weight loss, with clinical trials showing significant reductions in body weight.
Is Cissus quadrangularis a quick fix for bone health?
No, while it may support bone health, consistent use over months is necessary to observe significant benefits.