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Proprietary Botanical Blend

Also known as: Sphaeranthus indicus and Mangifera indica Blend, LI12542F6, SMI blend, East Indian globe thistle and Mango tree extract blend

Overview

The proprietary botanical blend combines extracts from *Sphaeranthus indicus* flower heads and *Mangifera indica* bark, both traditionally used in Ayurvedic medicine. This blend is marketed as a nutraceutical to enhance muscle strength, endurance, and physical performance, particularly for athletes and those engaged in resistance training. Research suggests the extracts, when standardized and combined, may have synergistic effects. Studies indicate improvements in muscle strength, endurance, and body composition. The blend is considered relatively new, with research primarily based on randomized controlled trials (RCTs) and preclinical studies. The available evidence suggests a moderate to high level of quality, supporting its potential benefits for physical performance.

Benefits

The primary benefit of this blend is enhanced muscle strength. A study in *Food & Nutrition Research* showed that 650 mg/day of the blend (LI12542F6) for 56 days significantly improved muscle strength in young men, increasing bench press by 12.3 kg, leg press by 15.6 kg, and handgrip strength by 4.3 kg compared to placebo. Another study in *Frontiers in Nutrition* found that 425 mg or 850 mg of the SMI blend for 56 days enhanced bench press and leg extension strength, as well as repetitions to failure, in recreationally active men, with the higher dose showing more pronounced effects. Secondary benefits include improved endurance, as measured by time to exhaustion, and improvements in body composition, such as increased mid-upper arm circumference and improved serum hormone levels. These benefits are primarily observed in young, healthy male populations engaging in resistance training.

How it works

The blend of *Sphaeranthus indicus* and *Mangifera indica* extracts is believed to enhance muscle strength and endurance through multiple biological pathways. Primarily, it activates the mTOR pathway and upregulates muscle-specific transcription factors like myogenin and myoD, which are crucial for muscle protein synthesis and hypertrophy. Additionally, it enhances nitric oxide (NO) generation in endothelial cells, improving blood flow and oxygen delivery to muscles. These interactions with the muscular and cardiovascular systems contribute to enhanced physical performance. Molecular targets include mTOR, myogenin, myoD, and endothelial nitric oxide synthase (eNOS).

Side effects

The proprietary blend is generally well-tolerated, with studies reporting no serious adverse events. Common side effects were not reported in the studies. Uncommon side effects (1-5%) included minor issues like generalized body aches, headache, fever, and abdominal discomfort, but these were evenly distributed between the supplement and placebo groups and were self-limiting. Rare side effects were not reported. There is limited information on drug interactions, so caution is advised, especially for individuals on other medications. No specific contraindications are mentioned, but those with underlying health conditions should consult a healthcare professional before use. Studies have primarily focused on young, healthy male populations, so the safety and efficacy in other populations (e.g., women, older adults) are not well established.

Dosage

The minimum effective dose appears to be around 425 mg/day of the SMI blend. The optimal dosage range is between 425 mg/day and 850 mg/day, with the higher dose showing more pronounced effects. Doses up to 850 mg/day were well-tolerated in studies. Supplements were taken daily, with instructions to consume capsules every morning. The studies used standardized extract blends in capsule form. No specific absorption factors were mentioned, but the oral route of administration was effective. No specific cofactors were identified as necessary for the efficacy of the blend.

FAQs

How should I use this blend for best results?

Use the blend in conjunction with a resistance training regimen to maximize benefits. Follow the recommended dosage and monitor for any adverse effects, although these are rare.

Is this blend safe for everyone?

The blend is generally well-tolerated, but individuals should be cautious and consult a healthcare professional if they have any underlying health conditions.

When and how should I take this supplement?

Take the supplements daily, preferably in the morning. Follow the dosage instructions provided on the product label.

What kind of results can I expect?

Users can expect improvements in muscle strength, endurance, and body composition over a period of several weeks with consistent use and a structured training regimen.

Is this a quick fix for muscle growth?

No, the blend is not a quick fix and requires consistent use and a structured training regimen to achieve significant benefits.

Research Sources

https://foodandnutritionresearch.net/index.php/fnr/article/view/8972 – This randomized, double-blinded, placebo-controlled trial with 40 male participants aged 18-40 years over 56 days found significant improvements in muscle strength (bench press, leg press, handgrip), endurance (time to exhaustion), and body composition compared to the placebo group. The study suggests that the *Sphaeranthus indicus* and *Mangifera indica* extract blend (LI12542F6) is effective in enhancing physical performance in young men.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1393917/full – This randomized, controlled trial with 99 male participants aged 22 ± 3 years over 56 days found significant improvements in muscle strength and endurance with both 425 mg and 850 mg doses of the SMI blend, with the higher dose showing more pronounced effects. The study indicates that the SMI blend is effective in enhancing muscle strength and endurance in young men, with a dose-dependent response.
https://www.4gauge.com/blogs/blog/what-are-proprietary-blends-and-why-should-you-avoid-them – This article discusses the general concerns around proprietary blends in supplements, highlighting the lack of transparency regarding ingredient dosages. It advises consumers to be cautious about proprietary blends and to seek products with clearly labeled ingredient amounts to ensure informed decision-making and safety.
https://ap-labs-usa.com/blogs/news/the-hidden-dangers-of-proprietary-blends-in-pre-workout-supplements – This blog post discusses the potential dangers of proprietary blends in pre-workout supplements, emphasizing the lack of transparency and potential for underdosing or inclusion of harmful ingredients. It advises consumers to carefully research and choose supplements with clearly labeled ingredients and dosages to ensure safety and efficacy.