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Proprietary Blend Of Proteases

Also known as: Proprietary Blend Of Proteases, Proteolytic enzymes, Digestive enzymes, Proteinases, Multi-enzyme blend, Protease Blend

Overview

Proprietary blends of proteases are mixtures of various proteolytic enzymes, typically sourced from fruits like papaya (papain), pineapple (bromelain), fig (ficin), kiwi (actinidin), and microbial fermentation (fungal or bacterial proteases). These blends are designed to enhance the digestion and absorption of dietary proteins by breaking them down into smaller peptides and amino acids. Primarily used as digestive enzyme supplements, they aim to alleviate symptoms of indigestion such as bloating and abdominal distension. Some formulations are also marketed for their potential role in sports nutrition to improve protein absorption and muscle recovery, and for their suggested anti-inflammatory properties. The effectiveness of these blends can vary due to differences in enzyme composition and activity across various proprietary formulations.

Benefits

Proprietary protease blends offer several evidence-based benefits, primarily centered around improved protein digestion and reduced digestive discomfort. Research indicates that these blends can significantly improve protein digestion and amino acid absorption, with one randomized controlled trial (RCT) showing elevated plasma amino acid concentrations within 30 minutes post-ingestion compared to a control group. This suggests enhanced nutrient availability, which could be particularly beneficial for athletes or individuals with high protein intake. Another placebo-controlled RCT demonstrated a significant reduction in meal-related bloating and abdominal distension, with participants experiencing 58-68% less discomfort within 30-90 minutes after a meal. While potential anti-inflammatory effects have been suggested due to systemic proteolytic activity, human trials have not yet conclusively demonstrated this benefit. The clinical significance of improved amino acid absorption on muscle hypertrophy requires further research, but the benefits for digestive comfort are more immediately apparent and clinically relevant for individuals experiencing post-meal bloating.

How it works

Protease blends function by hydrolyzing peptide bonds within dietary proteins, effectively breaking them down into smaller peptides and free amino acids. This enzymatic action facilitates their absorption in the small intestine. The blends are formulated to contain enzymes with diverse pH optima, ensuring activity across the varying pH environments of the gastrointestinal tract, from the acidic stomach to the more neutral small intestine. Plant-derived proteases like papain and bromelain maintain activity across a broad pH range, while microbial proteases can be engineered for enhanced stability. Some systemic absorption of these enzymes may occur, potentially contributing to anti-inflammatory effects, though this mechanism is less understood and requires further investigation.

Side effects

Proprietary protease blends are generally considered safe when consumed at recommended dosages, with clinical trials reporting a low incidence of adverse events. Mild gastrointestinal discomfort is the most commonly reported side effect, though it is rare. Allergic reactions are possible, particularly in individuals with known allergies to the source plants (e.g., pineapple, papaya), and can range from mild to rare hypersensitivity reactions. Caution is advised regarding potential drug interactions, especially with anticoagulants, as proteases may affect blood clotting. Individuals with bleeding disorders or known allergies to any component of the blend should avoid use. Data on safety during pregnancy and lactation are limited, so use in these populations should be approached with caution.

Dosage

The optimal dosage for proprietary protease blends varies significantly by formulation, as clinical studies often standardize doses based on proteolytic activity units (e.g., HUT or FCC units) rather than weight. Typical commercial blends provide several thousand HUT or FCC units per serving. There is no well-established maximum safe dose, but doses used in clinical studies have generally been well tolerated. For digestive support, these supplements are best taken with meals. For enhanced protein absorption, particularly in athletes, they may be taken with protein-containing meals or immediately post-exercise. Enteric-coated formulations are sometimes recommended to protect the enzymes from stomach acid and ensure their activity in the small intestine. The efficacy of these blends is often enhanced by combining enzymes with complementary pH optima, allowing for activity throughout the digestive tract.

FAQs

Does a proprietary blend of proteases improve protein absorption?

Yes, evidence suggests that these blends can increase plasma amino acid levels post-ingestion, indicating enhanced protein breakdown and absorption.

Are protease blends effective for reducing bloating?

Clinical trial data support their effectiveness in reducing abdominal distension and bloating symptoms after meals.

Are these blends safe?

Generally safe with a low incidence of side effects, though allergic reactions are possible, especially if allergic to source plants.

When should protease supplements be taken?

They are typically recommended to be taken with meals or protein-containing supplements for optimal digestive and absorption benefits.

Do protease blends increase muscle mass?

While they can enhance amino acid absorption, which supports muscle protein synthesis, direct effects on muscle hypertrophy require more research.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC7077235/ – This article discusses the impact of a protease supplement on protein digestion and amino acid absorption. It highlights an RCT showing increased total amino acid concentrations and nitrogen balance in healthy adults consuming a protease blend with whey protein, suggesting improved protein utilization.
https://www.dovepress.com/a-multi-digestive-enzyme-and-herbal-dietary-supplement-reduces-bloatin-peer-reviewed-fulltext-article-NDS – This placebo-controlled RCT investigated the effects of a multi-digestive enzyme and herbal supplement on bloating. It found a significant reduction (58-68%) in abdominal distension and improved subjective digestion in adults with bloating, demonstrating the blend's efficacy for digestive comfort.
https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2019.00110/full – This systematic review focuses on microbial proteases, discussing their engineering for improved stability and activity. It provides mechanistic insights into how these enzymes can be optimized for various applications, including their use in digestive supplements.