Get Your Personalized Supplement StackSupplement Stack Quiz

Polyethylene glycol 3350

Also known as: Polyethylene Glycol 3350, PEG 3350, MiraLAX

Overview

Polyethylene Glycol 3350 (PEG 3350) is a synthetic polymer primarily used as an osmotic laxative to treat constipation. It works by increasing the amount of water in the stool, making it easier to pass. PEG 3350 is not naturally derived but is synthesized for medical applications. It is available in powder form and is typically mixed with water before consumption. Research has consistently demonstrated its effectiveness and safety in managing constipation, with numerous randomized controlled trials and meta-analyses supporting its use. The quality of evidence is generally high, making it a reliable option for both short-term and long-term management of constipation.

Benefits

PEG 3350 is primarily effective in increasing bowel movement frequency and improving stool consistency. Studies have shown that a significant percentage of patients treated with PEG 3350 meet the FDA's responder criteria for constipation, showing substantial improvements compared to placebo. Secondary benefits include reducing symptoms like abdominal cramping and hard stools. It is particularly effective in adults with chronic idiopathic constipation. Research also suggests potential benefits in cirrhotic patients with hepatic encephalopathy, although more studies are needed to confirm this. Overall, PEG 3350 offers clinically significant improvements in bowel function with a strong evidence base.

How it works

PEG 3350 functions as an osmotic laxative by drawing water into the colon. This process softens the stool, increases its volume, and facilitates bowel movements. The compound itself is not absorbed in the gastrointestinal tract, ensuring that it remains in the gut to exert its laxative effect. It primarily affects the gastrointestinal system without significant systemic absorption or interaction with specific molecular targets. The mechanism is purely physical, based on osmotic principles, making it a straightforward and effective treatment for constipation.

Side effects

PEG 3350 is generally considered safe, but it can cause some side effects. Common side effects include gastrointestinal upset, such as bloating, gas, and nausea. Less common side effects include abdominal cramps and diarrhea. Rare side effects may involve electrolyte imbalances, although these are infrequent. There are few significant drug interactions reported. Contraindications include gastrointestinal obstruction and severe inflammatory conditions of the intestines. Caution is advised in patients with renal impairment or those at risk of electrolyte imbalances. It is important to monitor for any adverse effects and discontinue use if severe symptoms occur.

Dosage

The typical recommended dosage of PEG 3350 is 17 g once daily. This can be adjusted based on individual response, but generally should not exceed 34 g per day. It is best taken in the morning to facilitate bowel movements throughout the day. PEG 3350 is available in powder form and should be mixed with a full glass of water before consumption to ensure proper dissolution. As PEG 3350 is not absorbed, no cofactors are required. It is important to adhere to the recommended dosage to minimize the risk of side effects.

FAQs

How should I take PEG 3350?

Mix the powder with a full glass of water until fully dissolved. It's best taken in the morning for optimal results throughout the day.

Is PEG 3350 safe for long-term use?

Generally, it is considered safe for both short-term and long-term use, but it's important to monitor for any signs of electrolyte imbalance.

How quickly will PEG 3350 work?

You can expect an increase in bowel movement frequency within a few days of starting the treatment.

Does PEG 3350 affect other bodily functions?

No, PEG 3350 is not absorbed systemically, so it primarily affects the gastrointestinal system without impacting other bodily functions.

What are the common side effects?

Common side effects include bloating, gas, and nausea. If you experience severe symptoms, discontinue use and consult a healthcare provider.

Research Sources

https://www.ncbi.nlm.nih.gov/books/NBK80273/?report=reader – This resource provides general information about the use of polyethylene glycol as a bowel preparation. It discusses its effectiveness in cleansing the bowel before procedures and its safety profile, noting that it is generally well-tolerated.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9481403/ – This study evaluated the efficacy of polyethylene glycol (PEG) 3350 for treating constipation. The results indicated that PEG 3350 significantly increased bowel movement frequency and improved stool consistency compared to placebo, suggesting it is an effective treatment for constipation.
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1742-1241.2010.02397.x – This meta-analysis compared PEG 3350 to lactulose for treating constipation in adults. The findings suggest that PEG 3350 is more effective than lactulose in improving bowel movement frequency and stool consistency, providing strong evidence for its superior efficacy.
https://www.ijpsonline.com/articles/efficacy-and-safety-of-lactulose-and-polyethylene-glycol-in-the-treatment-of-constipation-a-metaanalysis-5042.html – This meta-analysis focuses on comparing the efficacy and safety of lactulose and polyethylene glycol (PEG) in the treatment of constipation. The study provides a quantitative synthesis of available evidence, highlighting the relative benefits and risks associated with each treatment option.
https://academic.oup.com/jcag/article/5/Supplement_1/118/6532819 – This review suggests that PEG 3350 may offer benefits in cirrhotic patients with hepatic encephalopathy by potentially reducing hospital stay. While the findings are promising, the authors note that further randomized controlled trials are needed to confirm these benefits and establish clear guidelines for use in this population.