Oxxynea
Also known as: Oxxynea®, polyphenol complex supplement, Oxxynea
Overview
Oxxynea is a proprietary, standardized plant-based extract designed to deliver a broad spectrum of bioactive polyphenols, equivalent to those found in approximately five servings of fruits and vegetables. It is derived from concentrated fruit and vegetable sources, providing a complex mixture of over 100 bioavailable polyphenols. Primarily intended as a dietary supplement to enhance antioxidant capacity and support metabolic health, especially for individuals with insufficient fruit and vegetable intake. Research indicates that Oxxynea provides sustained release of polyphenol metabolites over 24 hours, aiming to maintain prolonged systemic exposure. While the research on Oxxynea itself is in its early to moderate stages, with a few randomized controlled trials, it lacks extensive meta-analyses. However, the broader scientific literature on polyphenol supplementation supports its general benefits.
Benefits
Oxxynea supplementation has been shown to deliver sustained systemic exposure to multiple polyphenol metabolites, which may enhance antioxidant defenses and support metabolic processes related to oxidative stress management. A key study demonstrated that Oxxynea provides sustained systemic exposure to over 100 polyphenol metabolites with approximately 27% bioavailability, supporting its potential for antioxidant activity. While direct clinical outcome effect sizes on specific health markers are not clearly reported for Oxxynea, broader polyphenol research suggests potential improvements in cognitive functions, such as memory retrieval, and support for cardiovascular and metabolic health through antioxidant activity. Oxxynea may be particularly beneficial for individuals with low fruit and vegetable intake or increased oxidative stress, though specific population studies are limited. Single-dose studies indicate that the sustained presence of polyphenol metabolites lasts over 24 hours.
How it works
Oxxynea's mechanism of action primarily revolves around its rich polyphenol content. Polyphenols act as potent antioxidants, effectively scavenging free radicals and modulating oxidative stress pathways within the body. They also influence various signaling pathways related to inflammation and metabolism. Upon ingestion, the diverse polyphenols in Oxxynea undergo metabolism in the gut and liver, producing bioactive metabolites. These metabolites then circulate systemically, exerting their effects on cellular oxidative balance and inflammatory responses. Known molecular targets include antioxidant enzymes, inflammatory mediators, and cellular signaling proteins crucial for maintaining redox homeostasis. The formulation is designed to optimize absorption, with demonstrated bioavailability around 27%, ensuring that metabolites are detectable in plasma and urine for up to 24 hours, indicating sustained systemic exposure.
Side effects
Based on available randomized controlled trials, Oxxynea is generally considered safe as a polyphenol supplement, with no significant adverse effects reported. There are no common, uncommon, or rare side effects documented in the studies. While no specific drug interactions have been documented for Oxxynea, caution is advised when combining any polyphenol supplement with medications metabolized by cytochrome P450 enzymes, as polyphenols can potentially modulate their activity. There are no identified contraindications for Oxxynea. However, data regarding its safety for special populations, such as pregnant or lactating women, or children, are currently lacking. Therefore, use in these groups should be approached with caution or avoided until more research is available.
Dosage
Clinical studies on Oxxynea have primarily utilized a single 450 mg dose of the polyphenol extract. While this dose has demonstrated sustained polyphenol exposure over 24 hours, an optimal or maximum safe dosage range for daily or long-term supplementation has not yet been established due to limited data. The intended regimen appears to be daily supplementation. Oxxynea is typically administered in capsule form. Its bioavailability is influenced by individual metabolism and gut microbiota, and the formulation aims to optimize absorption and sustained release. There are no specific cofactors required for its efficacy. Users should adhere to the dosage recommended by the manufacturer or a healthcare professional, as long-term safety and efficacy data are still emerging.
FAQs
Is Oxxynea a substitute for fruits and vegetables?
No, Oxxynea is designed to complement, not replace, the dietary intake of fruits and vegetables. It provides a concentrated source of polyphenols but does not offer the full spectrum of nutrients found in whole foods.
How soon can benefits be expected?
Polyphenol metabolite exposure occurs within hours after intake, with sustained presence for 24 hours. However, observable clinical benefits on health markers require further long-term study.
Is it safe for long-term use?
Currently, there is no long-term safety data available for Oxxynea. Short-term use in studies has appeared safe, but long-term effects are not yet established.
Does it improve cognitive function?
General polyphenol research suggests possible cognitive benefits, such as improved memory retrieval. However, specific data on Oxxynea's direct impact on cognitive function are currently lacking.
Are there any known allergies?
No specific allergenic concerns have been reported for Oxxynea in the available research. However, individuals with known allergies to fruit or vegetable components should exercise caution.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10893550/ – This meta-analysis on polyphenols and memory, while not specific to Oxxynea, is a high-quality systematic review that supports the general benefits of polyphenol supplementation, particularly flavonoids, in improving immediate memory retrieval. It provides broader context for potential cognitive effects of polyphenol-rich supplements.
- https://www.fytexia.com/en/news/news/new-article-published-in-the-peer-review-journal-nutrients/ – This source refers to a study by Romain et al. (2022) published in Nutrients, a double-blind, randomized, cross-over trial. It found that Oxxynea supplementation resulted in sustained systemic exposure to over 100 polyphenol metabolites with approximately 27% bioavailability, supporting its antioxidant potential. The study was sponsored by Fytexia and focused on bioavailability rather than direct clinical outcomes.
- https://www.fytexia.com/en/news/news/a-24-hour-polyphenol-load-with-oxxynea-clinically-supported-solution/ – This source highlights the sustained 24-hour polyphenol load achieved with Oxxynea, indicating prolonged systemic exposure of its bioactive compounds. It reinforces the findings from the Romain et al. (2022) study regarding the sustained presence of polyphenol metabolites in the body after a single dose.
- https://d-nb.info/120716156X/34 – This source refers to a randomized controlled trial involving a nutrition and exercise intervention in older adults, where an Oxxynea-containing supplement was part of the intervention. It suggested that the supplement provided antioxidant potential equivalent to fruit/vegetable servings, but its isolated effect beyond exercise was unclear due to the combined intervention design.
- https://ouci.dntb.gov.ua/en/works/9j6bjpw9/ – This source likely refers to the same Romain et al. (2022) study, emphasizing the sustained systemic exposure to over 100 polyphenol metabolites and the approximate 27% bioavailability of Oxxynea. It underscores the product's ability to deliver a significant and prolonged polyphenol load to the body.
