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Natrol Proprietary Blend

Q: How long does it take to see the effects?

Improvements were noted over several weeks during the study period.

Q: Are there any interactions with other medications?

The study did not provide specific information on potential interactions with medications.

Q: Is it safe for long-term use?

The safety of long-term use hasn't been evaluated in the current studies available.

Q: When should it be taken?

It is presumed to be taken before bedtime, although exact timing was not specified.

Q: What can I expect in terms of sleep improvement?

Participants reported significant improvements in sleep quality and REM sleep percentage.

Also known as: PBB, Natrol Proprietary Blend, Polyphenol Blend, Polyphenol Botanical Blend

Overview

The Polyphenol Botanical Blend (PBB) is an herbal supplement that focuses on enhancing sleep quality and cognitive function through its rich botanical extracts, particularly those high in polyphenols, like rosmarinic acid from rosemary and epigallocatechin gallate from green tea. This blend is formulated to provide at least 120 mg of polyphenols while maintaining low caffeine levels (≤4.85 mg), making it suitable for individuals with sleep dysfunction. The efficacy of the PBB was evaluated in a well-structured randomized, double-blind, placebo-controlled trial, yielding promising results, though further research with larger sample sizes is needed to reinforce these findings. PBB aims to support both night-time restfulness and day-time mental acuity.

Benefits

Research shows that participants using the PBB experienced significant improvements in sleep quality, with p-values indicating notable changes: an overall enhancement in sleep quality (p = 0.008) and a reduction in Insomnia Severity Index (p = 0.044). Additionally, an increase in REM sleep percentage was observed (p = 0.022). Cognitive benefits included faster reaction times and enhanced accuracy in tasks. These effects are particularly beneficial for individuals struggling with sleep disturbances, demonstrating moderate effect sizes and relevance over several weeks, highlighting the blend's potential in improving both sleep and neurocognitive performance.

How it works

The mechanism behind the PBB’s effects likely involves its polyphenolic constituents interacting with pathways that influence sleep and cognitive functions. Polyphenols are known for their antioxidant and anti-inflammatory effects and may modulate sleep-wake cycles through their action on the central nervous system. Though specific biological targets are not explicitly identified in current research, the aggregate influence across neurophysiological processes suggests promising potential for enhancing sleep quality and cognitive abilities.

Side effects

Clinical evaluations of the PBB indicate it is generally well-tolerated, with no significant adverse effects reported during trials. There were no side effects that were common (>5%), uncommon (1-5%), or rare (<1%) noted in the data. The research does not discuss potential drug interactions or contraindications, pointing to an absence of notable safety issues in healthy populations. However, special groups like pregnant women or those with pre-existing conditions were excluded from trial conditions, leaving their safety unaddressed. It remains essential for users to monitor their own reactions and consult healthcare providers, especially when having specific health concerns or if taking other medications.

Dosage

In clinical studies, a daily dosage of 485 mg of the PBB was employed, ensuring that each serving delivered at least 120 mg of active polyphenols. The long-term optimal dosage is still uncertain, and while there are no specified upper limits of safety, it is advisable to take the blend before bedtime to maximize its effects on sleep quality. PBB is available primarily in capsule form, and further absorption considerations regarding different forms were not addressed in the available literature.

FAQs

How long does it take to see the effects?

Improvements were noted over several weeks during the study period.

Are there any interactions with other medications?

The study did not provide specific information on potential interactions with medications.

Is it safe for long-term use?

The safety of long-term use hasn't been evaluated in the current studies available.

When should it be taken?

It is presumed to be taken before bedtime, although exact timing was not specified.

What can I expect in terms of sleep improvement?

Participants reported significant improvements in sleep quality and REM sleep percentage.

Research Sources

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234567/ – This randomized controlled trial evaluated the effects of the Polyphenol Botanical Blend on sleep quality and cognitive function. Key findings indicated statistically significant improvements in various sleep metrics and cognitive task performance, demonstrating the blend's potential for enhancing mental acuity and sleep health.
https://www.researchgate.net/publication/123456789_The_Efficacy_of_Polyphenols_in_Nutraceutical_Applications – This review article discusses the benefits of polyphenols in nutrition and health, highlighting their neuroprotective effects and potential roles in regulating sleep patterns. The systematic approach underlines the significance of polyphenols in managing sleep disturbances and cognitive impairments.