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Lumbrokinase

Also known as: Eisenia fetida extract, Lumbrokinase enzyme, Fibrinolytic enzyme complex, Lumbrokinase

Overview

Lumbrokinase is a conglomerate of fibrinolytic enzymes sourced from the earthworm *Eisenia fetida*. It has gained attention for its capabilities in breaking down fibrin clots, primarily applied in treating ischemic cerebrovascular and peripheral arterial diseases. Lumbrokinase is known to lower fibrinogen concentrations and enhance blood fluidity, thus potentially improving blood circulation. Available primarily in powder form, it is most commonly marketed in capsules or tablets. Despite emerging evidence suggesting its efficacy in fibrin reduction, the clinical data remains limited, underscoring the need for more extensive trials to evaluate its safety and broader efficacy comprehensively. Variability in existing research highlights the need to approach its use with an understanding of its developing status in the scientific community.

Benefits

Research indicates that Lumbrokinase can significantly decrease fibrinogen levels, which is particularly beneficial for individuals suffering from ischemic cerebrovascular disease, with a noteworthy effect size of –0.67 (95% CI [–1.22, –0.12]; p=0.02). It may also assist patients with peripheral arterial disease, although improvements in measurements like the ankle-brachial index were not statistically significant. Users may begin to notice benefits within weeks to months, especially those with elevated fibrinogen levels. However, the general quality of research varies, highlighting an ongoing need for more precise and rigorous clinical studies to substantiate the findings.

How it works

Lumbrokinase operates by breaking down fibrin clots and reducing the levels of fibrinogen in the bloodstream, thereby enhancing blood flow and minimizing new clot formation. It promotes the body’s natural fibrinolytic processes, leading to increased fibrinolysis and improved cardiovascular health. The enzymes interact specifically with fibrin and fibrinogen, potentially altering their structure, which contributes to better circulation throughout the body.

Side effects

Lumbrokinase is typically considered safe, though comprehensive long-term safety data is still lacking. Reported side effects are not extensive, but some users have experienced gastrointestinal disturbances. The use of Lumbrokinase in conjunction with anticoagulants raises the risk of adverse effects, necessitating careful monitoring. Patients with bleeding disorders should avoid this supplement to prevent excessive bleeding risks. Furthermore, due to a lack of sufficient data on its effects during pregnancy and lactation, caution is advised for these groups to ensure safety.

Dosage

The effective dosage of Lumbrokinase has not been definitively established; however, a common recommendation suggests a range of 460 mg to 490 mg taken three times a day. It is advisable to consume Lumbrokinase with meals to facilitate absorption. Currently, the upper limit for safe dosage remains undetermined, and there are no specific co-factors required to maximize its efficacy.