Lactobacillus Gasseri Bnr17
Also known as: *Lactobacillus gasseri*, BNR17, Probiotic strain derived from human breast milk, *Lactobacillus gasseri* BNR17
Overview
*Lactobacillus gasseri* BNR17 is a probiotic strain sourced from human breast milk, recognized for its potential health benefits and primarily studied for its effects on obesity and irritable bowel syndrome (IBS). This strain is characterized by its ability to influence gut health and aid in weight management, with noticeable effects on reducing visceral fat and waist circumference. The current research maturity level of BNR17 is moderate, highlighted by a range of randomized controlled trials (RCTs) that present strong evidence of its efficacy; however, further comprehensive research is necessary to fully elucidate its mechanisms and long-term effects. Overall, the evidence supports its role as a beneficial probiotic, although more systematic reviews would enhance the understanding of its applications in clinical settings.
Benefits
1. **Obesity:** A double-blind RCT indicated that high doses of *L. gasseri* BNR17 reduced visceral adipose tissue (VAT) by 21.6 cm2 compared to placebo (P = 0.012). This effect was observed in a population of adults with a BMI of 25-35 kg/m2. 2. **Irritable Bowel Syndrome (IBS):** Limited studies suggest *L. gasseri* BNR17 may alleviate IBS symptoms, although the evidence quality is less robust than for obesity management. Overall, the primary population benefiting from *L. gasseri* BNR17 includes adults facing challenges with obesity and IBS, with moderate effect sizes for obesity-related outcomes. Benefits for gut health and potential weight management have been reported, typically noticeable within 12 weeks of usage, marking *Lactobacillus gasseri* BNR17 as a promising therapeutic adjunct.
How it works
*Lactobacillus gasseri* BNR17 functions by modulating the gut microbiota, which can influence fat metabolism and inflammatory responses within the gastrointestinal tract. Its primary biological pathway involves balancing harmful and beneficial bacteria, thereby enhancing metabolic health and supporting immune function. While specific molecular targets are not extensively defined, interactions with gut hormones and inflammatory markers are likely involved in its beneficial effects. The strain is generally well-absorbed as a probiotic supplement, albeit specific bioavailability studies are limited.
Side effects
Generally regarded as safe with minimal adverse effects, *Lactobacillus gasseri* BNR17 may cause gastrointestinal discomfort in some individuals, with symptoms like bloating and gas occurring in more than 5% of users. Allergic reactions are uncommon (1-5% occurrence), and severe allergies are rare (<1%). There are no significant known drug interactions associated with this strain. However, individuals who are immunocompromised should exercise caution. Additionally, pregnant or lactating women are advised to consult healthcare professionals before starting supplementation. Overall, while the safety profile is positive, awareness of individual responses is crucial.
Dosage
The minimum effective dose for *Lactobacillus gasseri* BNR17 is around 10^9 CFU per day, with optimal dosages ranging from 10^9 to 10^10 CFU daily. There are no well-established maximum safe doses, but it is generally recommended not to exceed 10^10 CFU per day. It is advisable to take the probiotic consistently at the same time each day, ideally on an empty stomach to enhance viability, although specific food interactions impacting absorption have not been extensively documented. No special cofactors are required for its efficacy.
FAQs
How should I store *Lactobacillus gasseri* BNR17?
Store in a cool, dry place to maintain the probiotic's viability.
Is it safe for everyone to take?
Generally considered safe; however, consult a healthcare provider if you are immunocompromised.
When is the best time to take it?
Take consistently once daily, preferably on an empty stomach for better absorption.
What results can I expect?
Results vary; improvements in weight and IBS symptoms may occur within a few weeks.
Is this a quick fix for obesity?
No, it's not a quick fix but part of a broader health strategy.
Research Sources
- https://www.semanticscholar.org/paper/Effect-of-Lactobacillus-gasseri-BNR17-on-irritable-Kim-Park/471921e824446150fd160469da598a1ef68f6343 – This RCT examined the effects of *L. gasseri* BNR17 on IBS symptoms, demonstrating potential benefits, though the exact duration of the study was not specified. While promising, the evidence was less definitive than findings related to obesity.
- https://pubmed.ncbi.nlm.nih.gov/29688793/ – A key randomized double-blind study revealed that high-dose *L. gasseri* BNR17 led to a significant reduction in VAT and waist circumference in adults, validating its use in managing obesity.
- https://www.mdpi.com/2072-6643/15/17/3856 – This analysis examined various studies concerning probiotics and their roles in obesity and IBS, confirming potential effectiveness of strains like *L. gasseri* in weight management while highlighting heterogeneity among study outcomes.
- https://onlinelibrary.wiley.com/doi/10.1111/obr.12626 – This systematic review focused on the impact of probiotics on obesity, noting that specific strains, including *L. gasseri*, could support weight control efforts, which aligns with current clinical insights.
- https://onlinelibrary.wiley.com/doi/full/10.1002/jcsm.13132 – A comprehensive meta-analysis on probiotics indicated that they might play an essential role in improving IBS symptoms and aiding in weight management, with *L. gasseri* included among effective strains.
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