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Lactobacillus delbrueckii

Also known as: L. delbrueckii, Lactobacillus delbrueckii subsp. bulgaricus, L. delbrueckii subsp. bulgaricus, Lactobacillus delbrueckii subsp. lactis, L. delbrueckii subsp. lactis, Probiotics, Lactobacillus delbrueckii

Overview

Lactobacillus delbrueckii is a species of lactic acid bacteria widely recognized for its probiotic properties and its presence in fermented foods like yogurt and kefir. It plays a crucial role in supporting gastrointestinal health, improving digestion, and enhancing immune function. These bacteria are acid-tolerant, enabling them to survive the harsh conditions of the stomach and reach the intestines, where they exert their beneficial effects by modulating the gut microbiota. Research on L. delbrueckii is substantial, with numerous studies examining its probiotic properties and health benefits. While evidence varies, high-quality systematic reviews and meta-analyses support its use, though more research is needed to fully understand its effects across different populations. It is available in various forms, including capsules, powders, and fermented foods.

Benefits

Lactobacillus delbrueckii is known to improve gut health by reducing symptoms of gastrointestinal disorders and enhancing immune response. Studies suggest it can modulate the gut microbiota, enhancing barrier function, and stimulating immune responses. There is some evidence supporting its use in conditions like ulcerative colitis and potentially in reducing inflammation, though more research is needed to confirm these effects. Benefits may vary across different populations, such as those with gastrointestinal disorders or compromised immune systems. The clinical significance of L. delbrueckii varies by study, with some showing significant improvements in gut health outcomes. The onset of benefits can vary, typically requiring regular consumption over several weeks to months.

How it works

Lactobacillus delbrueckii primarily acts by modulating the gut microbiota, enhancing barrier function, and stimulating immune responses. It interacts mainly with the gastrointestinal and immune systems. These bacteria influence pathways related to inflammation and immune modulation, such as the NF-κB signaling pathway. While not absorbed in the traditional sense, L. delbrueckii survives passage through the stomach to exert its effects in the intestines. By colonizing the gut, it helps to maintain a balanced microbial environment, which is essential for overall health and well-being.

Side effects

Lactobacillus delbrueckii is generally considered safe for consumption, with a long history of use in fermented foods. Common side effects, occurring in more than 5% of individuals, may include mild gastrointestinal symptoms like bloating or gas. Uncommon side effects, affecting 1-5% of users, may involve more severe gastrointestinal discomfort. Serious adverse effects are extremely rare, occurring in less than 1% of cases, but can include systemic infections in immunocompromised individuals. Generally, no significant interactions with medications have been reported. Caution is advised in severely immunocompromised individuals. Pregnant or breastfeeding women should consult healthcare providers before using probiotics. It is important to start with a low dose to assess tolerance and gradually increase as needed.

Dosage

Typically, doses of Lactobacillus delbrueckii range from 1 to 10 billion CFU (colony-forming units) per day. The optimal dose is not well established but generally falls within this range. There is no established maximum safe dose, but high doses are generally well-tolerated. It is best taken with food to enhance survival through the stomach. L. delbrueckii is available in capsules, powders, or as part of fermented foods like yogurt. Survival through the stomach is crucial for efficacy. No specific cofactors are required for its function. Individual responses may vary, so it's advisable to consult with a healthcare provider to determine the most appropriate dosage.

FAQs

Is Lactobacillus delbrueckii safe?

L. delbrueckii is generally safe and well-tolerated but may cause mild gastrointestinal symptoms in some individuals. Immunocompromised individuals should consult healthcare providers before use.

When is the best time to take Lactobacillus delbrueckii?

It is best taken with meals to enhance survival through the stomach, which improves its efficacy in the intestines.

How long does it take to see results from Lactobacillus delbrueckii?

Improvements in gut health and immune function may be noticed over several weeks of regular consumption.

Can Lactobacillus delbrueckii cure gut issues?

Probiotics are best used as part of a balanced diet and lifestyle, not as a sole cure. They support gut health but are not a replacement for medical treatment.

Are there any side effects?

Some individuals may experience mild gastrointestinal symptoms like bloating or gas, especially when first starting supplementation.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC10890272/ – A systematic review of 19 randomized trials involving 1412 participants showed diverse outcomes, with some studies indicating significant benefits in gut health. The review highlights the variability in study designs and outcomes, suggesting the need for more standardized research protocols to better understand the effects of Lactobacillus delbrueckii ssp. bulgaricus on gut health.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6927028/ – This study highlighted the probiotic properties of L. delbrueckii, including resistance to gastrointestinal stressors and anti-inflammatory effects, which are beneficial for treating gastrointestinal diseases. The genomic characterization provides insights into the mechanisms by which L. delbrueckii exerts its beneficial effects, supporting its use as a probiotic supplement.
https://onlinelibrary.wiley.com/doi/10.1155/2019/1484598 – A systematic review and meta-analysis on probiotics in NAFLD suggests that probiotics can be beneficial as a complementary therapy. While not specifically focused on *L. delbrueckii*, the findings imply potential benefits for *L. delbrueckii* if it shares similar mechanisms in improving liver health and reducing inflammation.
https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2022.912795/full – This research focuses on the bioinformatics aspects of Lactobacillus delbrueckii, providing insights into its genetic makeup and potential functionalities. The study contributes to a better understanding of the probiotic mechanisms of L. delbrueckii at a molecular level, which can aid in the development of targeted probiotic therapies.
https://www.frontiersin.org/journals/gastroenterology/articles/10.3389/fgstr.2022.983075/full – This article discusses the role of probiotics in ulcerative colitis, suggesting that certain strains, including Lactobacillus species, may have beneficial effects in managing the condition. The research highlights the potential of probiotics as an adjunctive therapy for ulcerative colitis, emphasizing the importance of strain-specific effects.