Cerecalase
Also known as: Cellulase, Cerecalase (misspelling), Carbohydrate-digesting enzyme
Overview
Cellulase is an enzyme complex that facilitates the breakdown of cellulose, a primary component of plant cell walls, into simpler sugars. Naturally produced by bacteria, fungi, and protozoa, it is utilized as a dietary supplement to enhance the digestion of plant-based foods, particularly those high in fiber. Cellulase comprises endocellulase, exocellulase, and beta-glucosidase, which synergistically hydrolyze cellulose. Research on cellulase as a digestive aid is relatively mature, encompassing in vitro, animal, and human studies. While systematic reviews are limited, existing evidence supports its role in improving fiber digestibility and alleviating gastrointestinal discomfort. It is also used in industrial applications such as textile and paper production. Cellulase is not absorbed into the bloodstream, acting locally within the gastrointestinal tract.
Benefits
Cellulase primarily functions as a digestive aid, improving the breakdown of plant-based foods by hydrolyzing cellulose, which humans cannot naturally digest. Studies indicate that cellulase supplementation enhances dietary fiber digestibility in healthy individuals. It may also alleviate symptoms of irritable bowel syndrome (IBS) by reducing gas and bloating associated with undigested fiber, although specific research is limited. Some evidence suggests potential benefits in weight management by improving fiber metabolism, but this requires further investigation. Additionally, cellulase may exert prebiotic effects, supporting beneficial gut bacteria growth. Clinical significance is generally modest, with small to moderate improvements in digestive symptoms typically observed within days to weeks of consistent use.
How it works
Cellulase functions by hydrolyzing the beta-1,4-glycosidic bonds in cellulose, breaking it down into simpler sugars like glucose and cellobiose. This enzymatic action occurs within the digestive system, specifically targeting cellulose molecules in plant-based foods. Cellulase enhances the breakdown of these foods in the gastrointestinal tract, improving fiber digestibility. The enzyme is not absorbed into the bloodstream but works locally to facilitate the digestion process. By breaking down cellulose, cellulase helps reduce the amount of undigested fiber, which can contribute to gas, bloating, and other digestive discomforts.
Side effects
Cellulase is generally considered safe, but gastrointestinal symptoms such as bloating, gas, and abdominal discomfort are common, especially upon initial use. Uncommon side effects include allergic reactions, though rare. Severe allergic reactions or anaphylaxis are extremely rare. There are no significant known drug interactions. Individuals with known allergies to fungi should avoid cellulase supplements, as some are derived from fungal sources. Pregnant or breastfeeding women should consult their healthcare provider before use due to limited specific studies in these populations. Overall, cellulase is well-tolerated, but monitoring for adverse effects is advisable, particularly in sensitive individuals.
Dosage
The minimum effective dose of cellulase typically starts at 100-200 units per serving. Optimal dosages range from 200-1000 units per serving, depending on individual needs and the specific formulation. There is no established maximum safe dose, but high doses are generally unnecessary and may increase the risk of gastrointestinal side effects. Cellulase should be taken with meals containing significant amounts of plant-based foods to maximize effectiveness. It is available in capsule, tablet, or powder form, with the choice depending on individual preference. Since cellulase works locally in the gastrointestinal tract, absorption factors are not relevant, and no specific cofactors are required for its activity.
FAQs
Is cellulase safe to use?
Cellulase is generally safe, but individuals with allergies to fungi should exercise caution. Monitoring for gastrointestinal side effects is advisable, particularly when starting supplementation.
When should I take cellulase?
Take cellulase with meals containing plant-based foods to maximize its effectiveness in breaking down cellulose and improving fiber digestion.
What results can I expect from taking cellulase?
Cellulase can improve fiber digestion, reduce symptoms of IBS, and potentially aid in weight management by enhancing the metabolism of dietary fiber.
Does cellulase digest all types of fiber?
No, cellulase specifically targets cellulose, a type of fiber found in plant cell walls. It does not aid in the digestion of all types of dietary fiber.
Research Sources
- https://www.mdpi.com/2076-0817/11/9/1045 – This study investigates the effects of enzyme supplementation on nutrient digestibility and growth performance in broilers. It highlights that enzyme supplementation, including cellulase, can improve the digestibility of dietary fiber, leading to enhanced growth performance in poultry. The research provides insights into the potential benefits of cellulase in improving nutrient utilization.
- https://libguides.usc.edu/healthsciences/systematicreviews/databases – This resource provides a guide to databases for conducting systematic reviews in health sciences. It lists key databases such as PubMed, Cochrane Library, and Web of Science, which are essential for identifying relevant studies on cellulase and its effects on digestive health. The guide aids researchers in conducting comprehensive literature searches.
- https://pubmed.ncbi.nlm.nih.gov/36731590/ – This study examines the impact of enzyme supplementation on the gut microbiota and metabolic profile in mice fed a high-fat diet. It reveals that enzyme supplementation can modulate the gut microbiota composition and improve metabolic parameters. The research suggests that cellulase may play a role in promoting a healthier gut environment.
- https://subjectguides.lib.neu.edu/systematicreview/databases – This guide offers a list of databases for conducting systematic reviews, including Cochrane Library, Embase, and Scopus. These databases are crucial for identifying and synthesizing evidence on the efficacy and safety of cellulase supplementation. The resource supports researchers in performing rigorous and comprehensive literature reviews.
- https://libguides.kcl.ac.uk/systematicreview/advanced – This advanced guide provides resources for conducting systematic reviews, including tips on searching databases and managing citations. It emphasizes the importance of using multiple databases and employing effective search strategies to identify all relevant studies. The guide assists researchers in conducting thorough and reliable systematic reviews.
Supplements Containing Cerecalase

Women's
GNC Ultra Mega Green

Multi-Enzyme Formula
GNC Preventive Nutrition

Multi-Enzyme Formula
GNC Preventive Nutrition

Digestive Enzymes
GNC Mega Men
Amplified Wheybolic Extreme 60 Vanilla
GNC Pro Performance AMP

Amplified Wheybolic Extreme 60 Chocolate
GNC Pro Performance AMP
Amplified Wheybolic Extreme 60 Vanilla
GNC Pro Performance AMP
Amplified Wheybolic Extreme 60 Vanilla
GNC Pro Performance AMP