Get Your Personalized Supplement StackSupplement Stack Quiz

Bioflavonoids Concentrate

Also known as: Bioflavonoids, Flavonoids, Polyphenols, Flavan-3-ols, Flavonols, Flavones

Overview

Bioflavonoids are a diverse group of plant-derived compounds known for their antioxidant properties, broadly classified within the flavonoid family. They are primarily found in natural foods such as fruits, vegetables, nuts, seeds, and tea. As dietary supplements, bioflavonoids are utilized for a variety of health benefits, particularly supporting immune function and cardiovascular health, alongside potential protective effects against chronic diseases linked to oxidative stress. Current research indicates bioflavonoids exert antioxidant, anti-inflammatory, and immune-modulating effects, with widespread investigations into their efficacy revealing varying strength and quality. Systematic reviews and meta-analyses contribute valuable insights into their benefits and safety profile.

Benefits

Bioflavonoids provide several evidence-based benefits: Significant reductions in the incidence and severity of acute respiratory tract infections (ARTIs) have been found, with a systematic review indicating a relative risk reduction of approximately 19% for ARTI incidence and a decrease in mean sick days by 0.56 days across various populations. Moreover, the potential of certain bioflavonoids, particularly from pine bark extract, has been noted for improving chronic disease symptoms, such as asthma, although the evidence varies in strength and reliability. Overall, bioflavonoids present considerable preventive effects for ARTIs, with clinical significance observed among different demographic groups.

How it works

Bioflavonoids function primarily through their antioxidant and anti-inflammatory properties. They modulate immune responses by reducing oxidative stress and the release of inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-α. These compounds engage with various biological pathways, influencing immune, cardiovascular, and respiratory systems to promote overall health. Their bioavailability can vary significantly, depending on the specific bioflavonoid, form taken, and presence of other nutrients.

Side effects

Bioflavonoids are generally deemed safe for most individuals. Systematic reviews have shown no significant increase in adverse reactions when compared to control groups. Common side effects, if any, are typically mild and infrequent. Less common side effects are not well-documented, and serious adverse reactions appear to be rare. Caution is advised when using bioflavonoids alongside certain medications due to potential interactions, though specific contraindications are not universally recognized. Individuals with pre-existing medical conditions, pregnant or breastfeeding women, and those on certain medications should seek medical advice prior to starting bioflavonoid supplementation.

Dosage

The appropriate dosage of bioflavonoids largely varies depending on the specific type being used and the condition intended for treatment. For preventing acute respiratory tract infections, studies suggest a dose range benefiting from antioxidant activity, which typically spans from 100 to 1000 mg per day. While there is no established maximum safe limit, dosages above 2000 mg per day have not been widely researched. Consistent daily intake is recommended for optimal efficacy, and absorption can be enhanced by combining with other nutrients, such as vitamin C. Formulations may include capsules, tablets, or extracts, which should be selected based on bioavailability.

FAQs

Are bioflavonoids safe to take?

Yes, bioflavonoids are generally considered safe, but individual tolerance and possible interactions with medications should be monitored.

How should I take bioflavonoids?

Consistent daily supplementation is recommended, although specific timing is not defined; consult health providers for tailored advice.

What benefits can I expect?

Users may see reductions in the incidence and severity of acute respiratory infections and improved outcomes for certain chronic conditions.

Can bioflavonoids cure diseases?

No, bioflavonoids are not a cure-all; they should be part of a broader health strategy.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/35940344/ – This systematic review and meta-analysis evaluated the effect of flavonoid supplements on the incidence of acute respiratory tract infections, finding a significant reduction in both incidence and number of sick days across 20 randomized controlled trials involving 4521 participants, indicating high-quality evidence for their preventive role.
https://www.cochrane.org/CD008294/CF_using-pine-bark-supplements-help-treat-variety-chronic-diseases – A Cochrane review of 27 RCTs assessing pine bark extract, rich in bioflavonoids, showed mixed results for various chronic conditions, revealing benefits for asthma symptoms but overall low certainty due to methodological limitations.
https://pubmed.ncbi.nlm.nih.gov/34190164/ – This systematic review examined micronutrient supplements for acute respiratory infections, concluding limited significant effects on risk, yet highlighting subgroup analyses that indicated potential benefits in certain populations.