ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2026 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
SuperFolate 400 mcg

SuperFolate 400 mcg

SuperSmart

#Other
88
Safety90
Efficacy85
Transparency80
Based on Examine, Wikipedia, and 23 other sources

Overview

SuperFolate 400 mcg utilizes Quatrefolic, which is a highly bioavailable and active form of folate. The dosage of 400 mcg of (6S)-5-methyltetrahydrofolic acid per serving aligns with standard recommendations for daily folate intake, especially for general health and foundational cellular support. While the total per serving from the label is 400 mcg, the label statements further clarify that two tablets provide 400 mcg of (6S)-5-methyltetrahydrofolic acid, meaning each tablet contains 200 mcg. This is an effective daily dose for many individuals, particularly when aiming for general support rather than addressing severe deficiencies, and for foundational health.

The Good

Provides highly bioavailable and active folate (Quatrefolic).

Does not require metabolic conversion, beneficial for individuals with MTHFR gene variations.

Supports essential bodily functions like DNA synthesis and red blood cell formation.

The Bad

Dosage may be insufficient for individuals with severe folate deficiencies or specific medical conditions requiring higher intake, necessitating consultation with a healthcare professional.

High doses of folate can mask a Vitamin B12 deficiency.

Contains common excipients like maltodextrin and shellac.

Is it for you?

Best For: Individuals seeking general folate support, pregnant women (consult doctor), those with MTHFR gene variations (consult doctor)

Skip If: You are on medication that interacts with folate, or have a known allergy to ingredients.

Ingredients Analysis

(6s)-5-Methyltetrahydrofolic Acid

400 mcg

Quatrefolic (6s)-5-Methyltetrahydrofolate; Glucosamine Salt

740 mg

How to Use

Take one capsule daily with water, or as directed by a healthcare professional.

Frequency:

Daily

Best Time:

Anytime

When:

With or without food

Who Should Use This

Best For:

Individuals seeking general folate support, pregnant women (consult doctor), those with MTHFR gene variations (consult doctor)