ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2026 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
St. John's Wort

St. John's Wort

Bronson

#Other
65
Safety55
Efficacy75
Transparency70
Based on Examine, Wikipedia, and 23 other sources

Overview

St. John's Wort extract is an herbal supplement primarily used for treating mild to moderate depression. Research supports its efficacy as an alternative to conventional antidepressants, with benefits typically observed within several weeks of consistent use. The 900mg dose per capsule aligns with clinically effective dosages.

The Good

Effective in treating mild to moderate depression.

May offer fewer side effects compared to conventional antidepressants.

Supported by multiple studies and meta-analyses demonstrating its efficacy.

The Bad

Significant drug interactions with common medications such as anticoagulants, HIV medications, and certain antidepressants.

May cause photosensitivity, increasing the risk of sunburn and eye damage with UV exposure.

Not recommended for pregnant or breastfeeding women due to potential risks.

Is it for you?

Best For: Individuals seeking mood support, those with mild to moderate depressive symptoms, general emotional well-being

Skip If: You are taking prescription medications (especially antidepressants, birth control, blood thinners), are pregnant or breastfeeding, or have severe depression.

Ingredients Analysis

St. John'S Wort Extract

900 mg

How to Use

Take 1 capsule daily, preferably with a meal, or as directed by a healthcare professional.

Frequency:

Daily

Best Time:

Morning or Evening

When:

With food

Who Should Use This

Best For:

Individuals seeking mood support, those with mild to moderate depressive symptoms, general emotional well-being

Recommended Articles

Herbal Boosters & COVID-19 Antivirals: Safe Mix?

Herbal Boosters & COVID-19 Antivirals: Safe Mix?

Herbal supplements may interact with COVID-19 antivirals, requiring careful consideration and further research.

How Mood Support Supplements Affect Neurotransmitters

How Mood Support Supplements Affect Neurotransmitters

Mood support supplements contain ingredients that can influence neurotransmitter levels, improving mood and cognitive function.

Boosting Health: Synergistic Ingredient Pairs

Boosting Health: Synergistic Ingredient Pairs

Combining certain ingredients, like curcumin and piperine, can significantly enhance their health benefits through synergy.

Avoid These Ingredients Before Surgery

Avoid These Ingredients Before Surgery

Certain ingredients, especially supplements that affect blood clotting, should be avoided before surgery to prevent complications.