ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
SAMe 400 mg

SAMe 400 mg

Protocol For Life Balance

#Other
65
Safety70
Efficacy60
Transparency80
Based on Examine, Wikipedia, and 23 other sources

Overview

SAMe 400mg by Protocol For Life Balance aims to support joint health, mood, and overall well-being. While SAMe has demonstrated potential benefits in improving mood and liver function in some studies, the overall evidence for its clinical efficacy remains limited, and more high-quality research is needed to substantiate these claims.

The Good

May support joint health by alleviating transient aches and pains.

Could play a role in maintaining a positive mood due to its involvement in neurotransmitter synthesis.

Potential benefits for liver health have been observed in some studies.

The Bad

Potential interactions with antidepressants and other serotonergic drugs.

May cause gastrointestinal disturbances such as nausea and diarrhea.

Can potentially induce mania in individuals with bipolar disorder.

Is it for you?

Best For: Individuals seeking mood support, liver health, or joint comfort

Skip If: You are pregnant, nursing, or taking antidepressant medications without consulting a doctor.

Ingredients Analysis

Same

400 mg

S-Adenosyl-L-Methionine Disulfate Tosylate

How to Use

Take 1 tablet 1 to 2 times daily, preferably on an empty stomach. Consult a healthcare professional for optimal dosage.

Frequency:

Daily

Best Time:

Morning or throughout the day

When:

Between meals

Who Should Use This

Best For:

Individuals seeking mood support, liver health, or joint comfort

Similar Products

SAMe by Metabolic Maintenance

SAMe

Metabolic Maintenance

SAMe by Allergy Research Group

SAMe

Allergy Research Group

SAMe by NutriCology

SAMe

NutriCology

Vetri-Science® Laboratories Healthymouth™ Natural Zeolites for Dogs & Cats Dental Health Supplement by Vetriscience®

Vetri-Science® Laboratories Healthymouth™ Natural Zeolites for Dogs & Cats Dental Health Supplement

Vetriscience®

SAMe 200 by ProThera

SAMe 200

ProThera

COLLAGEN PRO Pasture Raised Peptides UNFLAVORED DIETARY SUPPLEMENT by GNARLY®

COLLAGEN PRO Pasture Raised Peptides UNFLAVORED DIETARY SUPPLEMENT

GNARLY®

Recommended Articles

Top Immune Support Ingredients: What Works?

Top Immune Support Ingredients: What Works?

Vitamin D, zinc, and echinacea are key ingredients in immune support supplements, backed by scientific evidence.

L-Theanine Dosage for Focus: Avoid Drowsiness

L-Theanine Dosage for Focus: Avoid Drowsiness

200-400mg daily of L-theanine enhances focus without causing drowsiness, with benefits amplified when combined with caffeine.

Best Supplements for Cortisol Reduction: A Scientific Guide

Best Supplements for Cortisol Reduction: A Scientific Guide

Adaptogens like Ashwagandha and Rhodiola, along with Phosphatidylserine, are effective in reducing cortisol levels, supported by scientific studies.

Best Protein Types for Fitness Goals

Best Protein Types for Fitness Goals

Different protein types and sources are optimized for muscle gain, weight management, and overall health, catering to all diets.