ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors
  • Partners

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2026 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Melatonin + 5-HTP Time Release

Melatonin + 5-HTP Time Release

Natrol

#Sleep Aid
68
Safety70
Efficacy65
Transparency80
Based on Examine, Wikipedia, and 23 other sources

Overview

This supplement combines Melatonin, 5-HTP, and Vitamin B6 to promote sleep. Melatonin regulates the sleep-wake cycle while 5-HTP can help with mood regulation and serotonin production. Vitamin B6 also contributes to neurotransmitter synthesis. However, the effectiveness of this specific combination requires further research.

The Good

May improve sleep quality

Supports regulation of the sleep-wake cycle through melatonin

5-HTP may aid in mood regulation through serotonin

The Bad

Potential drug interactions

Mild side effects like nausea and headache

Not suitable for individuals with depression, migraine, Parkinson's disease or psychiatric disorders who are on medication

Is it for you?

Best For: Individuals seeking sleep support, those with occasional sleeplessness, people looking to improve mood and relaxation

Skip If: You are pregnant, nursing, taking medications (especially antidepressants or sedatives), or have a medical condition. Do not use with alcohol.

Ingredients Analysis

Vitamin B6

10 mg

5-Htp

50 mg

Melatonin

6 mg

How to Use

Take 1 tablet 20 minutes before bedtime. Do not exceed recommended dosage.

Frequency:

Daily

Best Time:

Evening

When:

Before bedtime

Who Should Use This

Best For:

Individuals seeking sleep support, those with occasional sleeplessness, people looking to improve mood and relaxation

Recommended Articles

Best Sleep Supplements: Ingredients & Doses

Best Sleep Supplements: Ingredients & Doses

Melatonin (0.5-5 mg) and Valerian root (300-600 mg) are highly recommended for improving sleep quality.

Best Times to Take Supplements for Health

Best Times to Take Supplements for Health

Consuming certain supplements at specific times can enhance sleep quality and energy levels, aligning with the body's circadian rhythm.

Best & Worst Sleep Supplements

Best & Worst Sleep Supplements

Melatonin, magnesium, and valerian root can improve sleep, while caffeine disrupts it.

Melatonin Dosage Guide for Sleep

Melatonin Dosage Guide for Sleep

Effective melatonin doses for adults range from 0.5 mg to 3 mg, with variations for children and older adults and consideration of potential side effects and medication interactions.