MEGA IgG2000

Microbiome Labs

#Other

Safety80

Efficacy65

Transparency85

Based on Examine, Wikipedia, and 23 other sources

Overview

MEGA IgG2000 is a supplement designed to support gut health and immune function, primarily through serum-derived immunoglobulin (IgG). Clinical evidence suggests modest improvements in gastrointestinal symptoms in specific populations with conditions like IBS-D. While it contains additional immunoglobulins and Bovine Serum Albumin, the research supporting their supplemental benefits is limited. Further long-term studies are needed to confirm the efficacy and safety of this product in broader populations.

The Good

Contains serum-derived immunoglobulin (IgG), which supports gut health and may help manage symptoms of IBS-D.

May help modulate immune responses and support gut barrier integrity.

Minimal systemic absorption, suggesting local action within the gut.

The Bad

Bovine-based product; not suitable for individuals with beef allergies.

Limited long-term safety data for IgG supplementation.

Potential for mild gastrointestinal side effects (bloating, flatulence) in some individuals.

Is it for you?

Best For: Individuals seeking gut health support, immune system modulation, those with leaky gut concerns

Skip If: You have a known allergy to dairy proteins (though it is dairy-free, cross-reactivity is possible for highly sensitive individuals), or are pregnant/nursing without consulting a doctor.