ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Homocysteine Supreme

Homocysteine Supreme

Designs for Health

#Other
70
Safety70
Efficacy70
Transparency85
Based on Examine, Wikipedia, and 23 other sources

Overview

Homocysteine Supreme combines several ingredients, including B vitamins, trimethylglycine, and N-acetylcysteine, to support homocysteine metabolism. The supplement contains high doses of some B vitamins, and includes Quatrefolic, a more bioavailable form of folate. While the ingredients are relevant, the effectiveness of this specific formulation requires consideration of individual needs and potential interactions.

The Good

Comprehensive B-vitamin complex

Includes Trimethylglycine (Betaine)

Contains N-Acetyl-Cysteine (NAC)

The Bad

Potential for excessive B-vitamin intake

N-Acetyl Cysteine may cause GI distress in some individuals

High doses of B12 may have unclear long-term risks

Is it for you?

Best For: Individuals looking to support healthy homocysteine levels, those with MTHFR gene variations, cardiovascular health support

Skip If: You are pregnant or nursing, have a medical condition, or are taking medications without consulting a healthcare professional.

Ingredients Analysis

Riboflavin

30 mg

Vitamin B-6

10 mg

Folate

3400 mcg

Quatrefolic (6s)-5-Methyltetrahydrofolate; Glucosamine Salt

4000 mcg

Vitamin B12

1000 mcg

Trimethylgylcine

900 mg

N-Acetyl-Cysteine

100 mg

How to Use

Take 2 capsules daily or as directed by your healthcare practitioner.

Frequency:

Daily

Best Time:

Anytime

When:

With food

Who Should Use This

Best For:

Individuals looking to support healthy homocysteine levels, those with MTHFR gene variations, cardiovascular health support

Similar Products

Folate (as Metafolin®) 1000 µg by Solgar®

Folate (as Metafolin®) 1000 µg

Solgar®

Folate 800 mcg DFE by Nature's Way

Folate 800 mcg DFE

Nature's Way

Folate 1667 mcg DFE Orange Blast by EZ Melts

Folate 1667 mcg DFE Orange Blast

EZ Melts

Folate by Haylie Pomroy

Folate

Haylie Pomroy

Folate 666 mcg DFE by Puritan's Pride

Folate 666 mcg DFE

Puritan's Pride

Folate by BIOVEA

Folate

BIOVEA

Recommended Articles

Top Nutrients for Nerve Health: What You Need to Know

Top Nutrients for Nerve Health: What You Need to Know

B vitamins, omega-3 fatty acids, magnesium, and vitamin D are crucial for maintaining healthy nerve function.

23andMe Genetics & Supplements: A Guide

23andMe Genetics & Supplements: A Guide

Your 23andMe genetics report can guide personalized supplement choices based on nutrient absorption and health predispositions.

Active B-Complex Vitamins: A Complete Guide

Active B-Complex Vitamins: A Complete Guide

Active forms of B-complex vitamins are more bioavailable, making them crucial for optimal health and absorption.

Beat Brain Fog: Key Ingredients & Foods

Beat Brain Fog: Key Ingredients & Foods

Natural antioxidants, omega-3 fatty acids, vitamins, and minerals are key to alleviating brain fog.