Berberine HCl

LES LABS, INC.

#Other

Safety70

Efficacy60

Transparency70

Based on Examine, Wikipedia, and 23 other sources

Overview

This supplement combines several ingredients known for their potential roles in metabolic health, particularly blood sugar regulation and antioxidant support. While the selection of ingredients is relevant to these goals, the dosages of key components like Berberine HCl and Alpha Lipoic Acid are likely insufficient to achieve the significant clinical benefits observed in research, particularly with a single capsule per day. The inclusion of Vanadyl Sulfate also adds an ingredient with limited and uncertain efficacy.

The Good

Multi-Ingredient Approach to Metabolic Support: Combines several compounds (Berberine, Chromium, ALA, Olive Leaf Extract, Vanadium) known to influence metabolic pathways.

Clinically Researched Ingredient (Berberine HCl): Berberine is a well-studied compound with moderate to high-quality evidence for improving glycemic control and lipid profiles.

Bioavailable Chromium Form: Includes Chromium Picolinate, which is known for its higher bioavailability compared to other chromium forms.

The Bad

Suboptimal Berberine Dose: The 250mg dose of Berberine HCl is lower than the common clinical dosages of 500-1500mg/day often divided.

Insufficient Olive Leaf Extract Oleuropein Content: While standardized to 20% oleuropein, the 250mg dose likely provides less oleuropein than clinically studied for most benefits (e.g., blood pressure studies often use 500-1000mg of extract).

Unestablished Vanadyl Sulfate Efficacy: The clinical significance of Vanadyl Sulfate's effects is uncertain due to mixed results and limited high-quality studies, with higher doses being more associated with side effects than benefits.