Yashtimadhu Powder
Also known as: Yashtimadhu, Licorice root, Glycyrrhiza glabra
Overview
Yashtimadhu powder is derived from the dried root of Glycyrrhiza glabra, a plant traditionally revered in Ayurveda for its rejuvenating (Rasayana) properties. Known for its distinct sweet flavor, it contains key bioactive compounds such as glycyrrhizin and glabridin. This supplement is primarily utilized for its beneficial effects on respiratory ailments like cough and bronchitis, digestive issues including ulcers and indigestion, and for general immune system support. It also shows promise in addressing certain skin conditions and may offer mental health enhancements. The therapeutic actions of Yashtimadhu are attributed to its antioxidant, anti-inflammatory, hepatoprotective, and neuroprotective properties. While its traditional use is extensive and supported by in vitro and animal studies, high-quality human randomized controlled trials (RCTs) and systematic reviews are limited, meaning much of the current evidence is preliminary or based on historical application.
Benefits
Yashtimadhu offers a range of evidence-based benefits, though the strength of evidence for many is still emerging from preclinical and traditional sources. For cognitive and mental health, some studies suggest improved memory and reduced oxidative stress in brain cells, primarily attributed to glabridin, indicating potential neuroprotective and cognitive-enhancing effects. For the respiratory system, it demonstrates anti-tussive (cough-suppressing) and expectorant properties, effectively soothing symptoms of cough and bronchitis. In the digestive system, Yashtimadhu exhibits anti-ulcer effects, promoting the healing of gastric and duodenal ulcers, and has documented hepatoprotective actions. It also supports the immune system through its antioxidant and immunostimulatory effects, potentially enhancing resistance to infections. Furthermore, it aids skin health by supporting wound healing, skin regeneration, and reducing hyperpigmentation. Preclinical studies also report anti-inflammatory, anti-bacterial, anti-fungal, anti-hemorrhoidal, and anti-malarial activities. However, quantitative effect sizes and clinical significance are not well established due to the limited number of high-quality randomized controlled trials.
How it works
Yashtimadhu's therapeutic effects stem from its bioactive constituents, primarily glycyrrhizin and glabridin. These compounds exert antioxidant effects by effectively scavenging free radicals, thereby reducing oxidative stress in various tissues, including the brain and liver. Its anti-inflammatory actions are mediated through the inhibition of pro-inflammatory cytokines and enzymes, which helps to mitigate inflammatory responses throughout the body. The hepatoprotective effects involve stabilizing liver cell membranes and modulating detoxification enzymes, supporting liver function. Neuroprotective benefits may arise from reducing neuronal oxidative damage and enhancing overall neuronal function. Glycyrrhizin is metabolized by intestinal bacteria into active metabolites, contributing to its systemic effects. The absorption and bioavailability of these compounds can vary depending on the specific preparation of Yashtimadhu.
Side effects
Yashtimadhu is generally considered safe when used within traditional dosage guidelines. Mild gastrointestinal discomfort is a common side effect, occurring in more than 5% of users. However, prolonged or high-dose use, particularly due to the glycyrrhizin content, can lead to pseudoaldosteronism. This condition, though uncommon, is clinically significant and can manifest as hypertension (high blood pressure), hypokalemia (low potassium levels), and edema (fluid retention). Yashtimadhu may interact with certain medications; it can potentiate the effects of corticosteroids and diuretics, and caution is advised when used concurrently with antihypertensive drugs due to the risk of additive effects on blood pressure. Contraindications for its use include pre-existing hypertension, heart disease, and pregnancy, primarily due to potential hormonal effects. Special populations, such as the elderly and individuals with renal or cardiovascular conditions, should use Yashtimadhu with caution and under medical supervision.
Dosage
Traditional Ayurvedic doses of Yashtimadhu powder typically range from 1 to 3 grams daily, taken orally. The specific dosage may vary based on the intended therapeutic purpose and individual response. When using standardized extracts, it is crucial to monitor the glycyrrhizin content to prevent potential toxicity, as concentrations can differ significantly from raw powder. For optimal absorption and to soothe mucous membranes, Yashtimadhu is often recommended to be taken with warm water or honey. There is no established maximum safe dose derived from randomized controlled trials, emphasizing the need for caution against chronic high-dose use due to the potential for adverse effects, particularly those related to glycyrrhizin accumulation. Users should adhere to recommended dosages and consult a healthcare professional for personalized guidance.
FAQs
Is Yashtimadhu safe for long-term use?
Generally, Yashtimadhu is safe in moderate doses for short periods. However, long-term high doses carry a risk of mineralocorticoid side effects like hypertension and hypokalemia due to glycyrrhizin content.
Can it improve memory?
Preliminary evidence suggests cognitive benefits, including improved memory, linked to its antioxidant effects. However, robust clinical trials are currently lacking to confirm these effects definitively.
Does it interact with medications?
Yes, Yashtimadhu can interact with certain medications. It may potentiate the effects of corticosteroids and diuretics, and caution is advised when used with antihypertensive drugs.
What is the best form to take?
The traditional form is the powdered root. Standardized extracts are also available and may offer more consistent dosing, but require careful monitoring of glycyrrhizin content.
Research Sources
- https://ayushdhara.in/index.php/ayushdhara/article/download/479/411/1104 – This review by Nanda et al. (2019) discusses the antioxidant and neuroprotective effects of Yashtimadhu, highlighting its potential to improve memory and reduce oxidative stress in experimental models. The evidence presented is primarily preclinical and from small-scale clinical observations, indicating a need for larger, more rigorous studies.
- https://iamj.in/posts/2025/images/upload/1393_1397_1.pdf – Mohanty et al. (2025) provide a comprehensive overview of Yashtimadhu's pharmacological actions across various body systems, including respiratory, digestive, immune, and skin benefits. This narrative review primarily cites traditional uses and some clinical studies, but does not include meta-analyses or large-scale randomized controlled trials.
- https://hamc.org.in/himalayan/document/therapeutic-and-medicinal-uses-of-yashtimadhu-a-review.pdf – This review by Garg et al. summarizes multiple pharmacological effects of Yashtimadhu, such as anti-inflammatory, anti-ulcer, and immunostimulatory properties. The evidence is largely based on in vitro and animal studies, with limited clinical trial data available, underscoring the preliminary nature of some findings.
