White Grape Extract
Also known as: White grape extract, White grape polyphenol extract, Vitis vinifera (White Grape Extract)
Overview
White grape extract is derived from the *Vitis vinifera* plant, particularly from white grape varieties known for their high content of polyphenols, including flavonoids, phenolic acids, and stilbenes. These polyphenolic compounds bestow significant antioxidant and anti-inflammatory properties, which have prompted a range of potential health benefits associated with their consumption. While often utilized in the context of health supplements, the body of research specifically targeting white grape extract is not as extensive as that of other grape products, like red wine or grape seed extract. Research supports the general health benefits of grape polyphenols, particularly in reducing oxidative stress and inflammation, but the direct effects of white grape extract are less established, emphasizing a need for further investigation into its specific benefits and mechanisms of action.
Benefits
Evidence for the benefits of white grape extract is currently limited but suggests several potential health effects. General grape products rich in polyphenols are known to reduce inflammation biomarkers such as C-reactive protein (CRP), demonstrated in a meta-analysis which found a significant reduction with a standardized mean difference (SMD) of -0.229. Potential cognitive improvements and better glycemic control have also been suggested through studies involving grape-derived compounds, particularly in populations with pre-existing health conditions. However, due to the nascent state of research on white grape extract specifically, clinical significance and empirical support for these benefits require caution in interpretation and application.
How it works
The beneficial effects of white grape extract primarily stem from its polyphenol content, which engages biological pathways related to oxidative stress and inflammation. Polyphenols can modulate levels of oxidative stress markers and inflammatory cytokines, thus influencing cardiovascular and immune responses. The absorption and bioavailability of these compounds generally occur in the gut, where they are further metabolized by the liver, possibly affecting their effectiveness in the body.
Side effects
White grape extract is generally regarded as safe for most individuals when consumed within reasonable limits. However, specific side effect documentation is lacking for white grape extract. Commonly encountered issues with similar polyphenol-rich supplements may include gastrointestinal disturbances such as upset stomach or diarrhea, though such instances are infrequent (<5%). There are potential interactions with anticoagulant medications and hypoglycemic agents, which necessitate caution among users on these medications. While no significant contraindications are noted, individuals with allergies to grapes should avoid this extract. Pregnant or breastfeeding women should also consult healthcare professionals before using white grape extract due to limited safety data in these populations.
Dosage
Due to a lack of specific studies, no established minimum effective dose for white grape extract exists. Broadly, grape polyphenol extracts are used within dosages ranging from 100 to 500 mg per day. Safety thresholds, while not rigorously defined for white grape extract, indicate that high intakes of polyphenols may lead to gastrointestinal discomfort. No precise dosing timings are recommended, and bioavailability may improve when consumed with fatty meals. Each extract may come in various forms, including capsules and powders, which can influence absorption characteristics. Users should remain aware of the potential for adverse effects at high doses.
FAQs
Is white grape extract safe to use?
Generally, white grape extract is considered safe; however, consult a healthcare provider, especially if taking medications, due to potential interactions.
What are the expected results from taking white grape extract?
While potential benefits include reduced inflammation and oxidative stress, evidence is primarily indirect and requires more targeted research.
When should I take white grape extract?
No specific timing is recommended for white grape extract; regular daily intake is suggested for consistent effects.
Can white grape extract cause side effects?
Potential side effects may include gastrointestinal discomfort, but these are not well-documented. Consult a healthcare provider if concerns arise.
How does white grape extract compare to other grape products?
While white grape extract shares beneficial properties with other grape products, specific evidence for its effects is still emerging.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/34107109/ – This meta-analysis with 668 participants found that grape products significantly reduce CRP levels, indicating potential anti-inflammatory effects. The study suggests moderates to high quality in evidence, although specifics on white grape extract are lacking.
- https://pubmed.ncbi.nlm.nih.gov/32921322/ – This systematic review involving 1,297 participants concluded that grape product supplementation can lower insulin resistance but does not significantly affect fasting insulin or HbA1c levels, highlighting the need for focused studies on white grape extract.
- https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-grape-products-containing-polyphenols-on-creactive-protein-levels-a-systematic-review-and-metaanalysis-of-randomised-controlled-trials/59C5DC9AEC42490227F9CE5B8C35D87B – This systematic review and meta-analysis evaluated randomized controlled trials and found significant reductions in CRP levels from grape polyphenol products, establishing a focus area for future research on specific extracts like white grape.
- https://pubmed.ncbi.nlm.nih.gov/33893683/ – This systematic review and meta-analysis encompassing 23 studies indicated that grape seed extract decreases markers of oxidative stress and has mild anti-inflammatory properties; however, results are not directly applicable to white grape extract.
- https://academic.oup.com/nutritionreviews/article/80/3/367/6285577?login=false – The systematic review provided insights into various grape products' effects on health markers, emphasizing the positive outcomes on metabolic indices while pointing out the gaps concerning specific findings related to white grape extract.
Supplements Containing White Grape Extract
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