White Atractylodes Rhizome Extract
Also known as: White Atractylodes Rhizome, Bai Zhu, *Atractylodes macrocephala*
Overview
*Atractylodes macrocephala* is a perennial plant native to China, predominantly used in traditional Chinese medicine (TCM) for its rhizome. This herb is valued for its potential health benefits, particularly its role in enhancing digestion and reducing dampness in the body. The rhizome is rich in bioactive compounds such as phenolic acids and flavonoids, which contribute to its antioxidant effects. Although a growing body of research suggests beneficial effects, particularly in cancer therapy, high-quality clinical trials are still notably limited. Most studies originate from China, highlighting the need for more rigorous investigations to substantiate the claims surrounding its efficacy in various health applications.
Benefits
Evidence-based benefits of *Atractylodes macrocephala* have been primarily noted in patients with advanced gastric cancer who undergo neoadjuvant chemotherapy. A systematic review indicated a significant improvement in the objective response rate (ORR) and disease control rate (DCR) when used in combination with chemotherapy, with an RR of 1.41 (95% CI: 1.27-1.57, P < 0.001) for ORR and 1.20 (95% CI: 1.13-1.27, P < 0.001) for DCR. Additionally, it may enhance quality of life and mitigate adverse side effects linked to chemotherapy treatments. While its benefits are most evident in oncological settings, the potential for improving overall health remains largely anecdotal.
How it works
The therapeutic effects of *Atractylodes macrocephala* are attributed to its antioxidant properties stemming from phenolic acids and flavonoids, which can neutralize free radicals and chelate metals in the body. These actions potentially enhance immune function, increasing certain T-cell populations and modulating immune responses. The exact biological pathways and molecular targets remain inadequately defined and warrant further research for clarity.
Side effects
Generally regarded as safe within traditional contexts, comprehensive safety data for *Atractylodes macrocephala* is scant. Common side effects (>5%) are not clearly documented; however, some individuals might experience gastrointestinal disturbances or hypersensitive reactions at lower frequencies (1-5%). Rare side effects (<1%) are not well-characterized in existing literature. The potential for drug interactions, especially with chemotherapy agents, is acknowledged, but the herb has shown beneficial effects in these combinations. Due caution is advised during pregnancy and lactation due to lack of substantial data, and contraindications are not well-defined.
Dosage
Dosage recommendations for *Atractylodes macrocephala* vary significantly, as standardized dosages have not been established in Western clinical studies. In traditional Chinese medicine, dosages typically differ based on formulation and purpose. It is generally advised to use this herb in conjunction with meals, often as part of a broader herbal regimen. The maximum safe dosage remains undefined. Factors affecting absorption include the extraction method and herbal form, which can range from capsules to teas.
FAQs
How is *Atractylodes macrocephala* typically used?
This herb is generally used in combination with other traditional herbs, especially in Chinese medicine.
Is *Atractylodes macrocephala* safe to use?
While it's considered safe, comprehensive safety studies are limited, so caution is warranted.
When should *Atractylodes macrocephala* be taken?
It is typically consumed orally with meals to enhance absorption.
What benefits can I expect from using *Atractylodes macrocephala*?
It may improve digestion and overall wellness, particularly in patients undergoing chemotherapy.
Are there common misconceptions about *Atractylodes macrocephala*?
Some believe it has broad benefits; however, scientific support mainly focuses on its use in cancer treatment.
Research Sources
- https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1431381/full – A systematic review and meta-analysis of 32 studies highlighted that *Atractylodes macrocephala* combined with neoadjuvant chemotherapy significantly improved objective response and disease control rates in advanced gastric cancer patients, underscoring the need for additional high-quality randomized trials.
- https://www.mdpi.com/1420-3049/17/11/13457 – This study focused on the antioxidant activity of *Atractylodes macrocephala*, concluding that its beneficial properties are largely attributable to phenolic acids and flavonoids, while also noting the necessity for further clinical relevance research.
- https://bmjopen.bmj.com/content/bmjopen/5/12/e007291.full.pdf – This research explores multiple studies involving *Atractylodes macrocephala* and its traditional efficacy, highlighting mostly moderate-quality evidence and a call for more rigorous trials.
- https://pubmed.ncbi.nlm.nih.gov/32987126/ – The article provides foundational insights into the traditional medicinal uses and therapeutic potentials of *Atractylodes macrocephala*, reinforcing its historical context in TCM.
- https://academic.oup.com/toxres/article/doi/10.1093/toxres/tfae035/7625491 – This paper discusses the safety considerations of various herbs including *Atractylodes macrocephala*, emphasizing that while traditionally used safely, higher-quality data on its safety profile is necessary.