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Urolithin A Production Support Proprietary Blend

Also known as: Urolithin A, UA

Overview

Urolithin A is a gut metabolite derived from ellagic acid, a compound found in foods like pomegranates and berries. It is being actively researched for its potential geroprotective effects, including enhancing muscle endurance and potentially improving cognitive function. Urolithin A is known for its anti-inflammatory properties and its ability to enhance mitochondrial function through the activation of mitophagy, a process that removes damaged mitochondria. This enhancement of mitochondrial function is believed to be a key mechanism behind its potential benefits. While research is still emerging, Urolithin A shows promise in various fields, including healthy aging and sports nutrition. The available evidence suggests potential benefits, but further rigorous clinical trials are needed to fully establish its efficacy and safety. It is available as a dietary supplement.

Benefits

Urolithin A has demonstrated the potential to increase muscle strength and endurance in human studies. Some research indicates improvements in running capacity in mice by up to 65%. These effects are attributed to its ability to enhance mitochondrial function and reduce inflammation. Emerging evidence suggests it may also have osteoprotective effects and delay joint degeneration by reducing inflammation, indicating potential benefits for bone health. The clinical significance of these benefits is still under investigation, but the findings are promising for enhancing physical performance and supporting healthy aging. Benefits have been observed over durations ranging from 28 days to several months in clinical trials.

How it works

Urolithin A primarily works by enhancing mitochondrial function through the activation of mitophagy, a process that removes damaged mitochondria and promotes the generation of new, healthy mitochondria. This process improves cellular energy production and efficiency. Additionally, Urolithin A activates AMPK signaling, a key regulator of cellular energy homeostasis. By improving mitochondrial function and activating AMPK, Urolithin A interacts with the musculoskeletal and cardiovascular systems, leading to improved muscle endurance and potential benefits for bone health. These mechanisms contribute to its potential geroprotective effects and benefits in sports performance.

Side effects

Urolithin A is generally considered safe, with mild to moderate unrelated adverse events reported in clinical trials. Common side effects are not well-documented in the available literature, and uncommon or rare side effects have not been specifically reported. No significant drug interactions or contraindications have been documented. However, long-term effects and interactions are not yet fully understood, and further research is needed to comprehensively assess its safety profile. As a precaution, specific guidance is lacking for pregnant women, children, or individuals with chronic conditions, and caution is advised for these populations. Individuals should monitor their tolerance and consult with a healthcare professional before use.

Dosage

Studies have explored a wide range of Urolithin A dosages, from 10 to 1000 mg per day. However, an optimal dosage range has not yet been definitively established, and further research is needed to determine the most effective and safe dose. Some research suggests pre-exercise dosing may be beneficial for sports performance, but specific timing recommendations are still tentative. Form-specific recommendations and absorption factors are not well-detailed in the available literature. Due to the limited data on maximum safe doses, it is advisable to start with a lower dose and gradually increase it while monitoring for any adverse effects. Consultation with a healthcare professional is recommended to determine an appropriate dosage based on individual needs and health status.

FAQs

What is Urolithin A and what are its potential benefits?

Urolithin A is a gut metabolite derived from ellagic acid, found in pomegranates and berries. It's being studied for its potential to enhance muscle endurance, improve mitochondrial function, and support healthy aging. More research is needed.

Is Urolithin A safe to use?

Urolithin A is generally considered safe, with mild side effects reported in studies. However, long-term effects and interactions are not fully understood. Consult a healthcare professional before use, especially if you have existing health conditions.

How should I take Urolithin A for best results?

While optimal dosage is still under investigation, studies have used doses ranging from 10 to 1000 mg/day. Pre-exercise dosing may be beneficial for sports performance. Consult with a healthcare provider for personalized recommendations.

What are the expected results from taking Urolithin A?

Urolithin A may improve muscle endurance and strength, with potential cognitive benefits. However, individual results may vary, and it is not a cure for aging or diseases. It may support healthy aging and physical performance.

Are there any misconceptions about Urolithin A?

Urolithin A is not a cure for aging or diseases. While it shows promise in supporting healthy aging and physical performance, it should be viewed as a supplement to a healthy lifestyle, not a replacement for medical treatment.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/39002645/ – A systematic review of Urolithin A's geroprotective effects on 250 healthy individuals over 28 days to 4 months found dose-dependent anti-inflammatory effects and increased muscle strength and endurance. The review noted no effects on mitochondrial ATP production or gut microbiota, providing a comprehensive overview of current human studies.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1585922/full – This review highlights the emerging evidence of Urolithin A in sports nutrition, noting its potential to enhance muscle endurance and peak oxygen uptake, with possible benefits for bone health. The authors emphasize the need for further human trials to validate ergogenic claims, suggesting Urolithin A's potential in sports nutrition but stressing the need for more research.
https://www.mdpi.com/2072-6643/14/17/3494 – A systematic review on the therapeutic relevance of urolithins, including Urolithin A, suggests they have therapeutic potential due to their effects on mitochondrial function and autophagy. The review synthesizes available data but does not provide specific clinical trial results, offering a broad perspective on the therapeutic potential of urolithins.
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13847 – This research explores the potential of Urolithin A in the context of Alzheimer's disease, investigating its effects on cognitive function and neuroprotection. The study provides insights into the possible therapeutic applications of Urolithin A in neurodegenerative conditions, highlighting its role in promoting brain health.
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Urolithin_A_UPDATE_(supplement).pdf – This resource provides an update on Urolithin A as a supplement, focusing on its cognitive vitality and potential benefits for brain health. It summarizes the current understanding of Urolithin A's role in supporting cognitive function and overall brain health, offering a concise overview of its potential applications.