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Uraria Picta Extract

Also known as: Uraria picta Jacq., Prishniparni, Uraria picta

Overview

Uraria picta is a plant species belonging to the Fabaceae family, native to tropical regions and traditionally used in folk medicine. It is recognized for its potential antioxidant, antihypertensive, and antimicrobial properties. The plant contains various compounds, including eugenol, steroids, and isoflavones, which contribute to its pharmacological activities. While traditionally used for various health conditions, including hypertension and infections, the research on Uraria picta is still emerging, with most studies being preclinical or in vitro. Limited human trials are available, indicating a need for more comprehensive research to validate its benefits and safety. It is available primarily as an herbal extract.

Benefits

Uraria picta extract has demonstrated potential health benefits, primarily supported by preclinical studies. Animal studies suggest an antihypertensive effect, with significant reductions in blood pressure and serum ACE levels observed in rats. Additionally, the extract exhibits moderate antibacterial activity against MRSA strains, with a Minimum Inhibitory Concentration (MIC) ranging from 64 to 128 µg/mL. Its antioxidant properties may contribute to overall health benefits. However, the limited availability of human studies necessitates further research to confirm these benefits and determine their clinical significance in human populations. More research is needed to determine the effect sizes and time course of benefits.

How it works

Uraria picta's mechanism of action involves several biological pathways. Its antihypertensive effects are thought to be mediated through antioxidant activity and ACE (Angiotensin-Converting Enzyme) inhibition. The extract may interact with the cardiovascular and immune systems, potentially targeting the ACE enzyme and nitric oxide pathways. However, the exact mechanisms and molecular targets are not fully understood, and further research is needed to elucidate the precise interactions and pathways involved. The absorption and bioavailability of its active compounds also require further investigation.

Side effects

The safety profile of Uraria picta is not well-established due to the lack of formal safety studies. While it has been traditionally used without significant reported adverse effects, comprehensive data on side effects are lacking. Potential drug interactions, especially with blood pressure medications, should be considered. Contraindications are not well-defined. Pregnant or breastfeeding women should exercise caution and consult healthcare providers before use due to insufficient safety data. Given the limited information, caution is advised, and users should be vigilant for any adverse reactions. It is important to note that common, uncommon, and rare side effects are currently undocumented.

Dosage

Due to limited human studies, there is no established minimum effective dose, optimal dosage range, or maximum safe dose for Uraria picta. Animal studies have used doses ranging from 100 to 400 mg/kg, but these cannot be directly translated to human dosing. The timing of administration is not specified, and it is typically used as an extract. Absorption factors and required cofactors are not well-studied. Given the lack of standardized dosing guidelines, it is crucial to consult with a healthcare provider before using Uraria picta to determine an appropriate and safe dosage.

FAQs

Should I consult a healthcare provider before using Uraria picta?

Yes, it is essential to consult a healthcare provider before using Uraria picta, especially if you are currently taking medications or have underlying health conditions, due to the potential for drug interactions and the lack of comprehensive safety data.

Is Uraria picta safe to use?

Formal safety data on Uraria picta are lacking, so caution is advised. Pregnant or breastfeeding women should avoid use. Consult a healthcare provider before use, especially if you have underlying health conditions.

What are the expected benefits of using Uraria picta?

Uraria picta has potential benefits for blood pressure and infections, but more research is needed to confirm these effects. Results may vary, and it is not a substitute for conventional medical treatment. Consult a healthcare provider for guidance.

Research Sources

https://www.biotech-asia.org/vol18no3/effect-of-extract-of-uria-picta-jacq-on-experimentally-induced-hypertension-in-wistar-rats/ – This animal study investigated the effects of Uraria picta extract on experimentally induced hypertension in Wistar rats. The key finding was that the extract significantly reduced blood pressure and serum ACE levels in the hypertensive rats, suggesting a potential antihypertensive effect. However, the study is limited by its animal model and the need for human trials to validate these findings.
https://researchprofiles.herts.ac.uk/files/62855855/JMNP-2024-405-online_final_1_.pdf – This phytochemical analysis isolated compounds like eugenol from Uraria picta, demonstrating potential antimicrobial activity. The study found moderate antibacterial activity against MRSA strains, with a MIC of 64–128 µg/mL. While these in vitro results suggest antimicrobial properties, in vivo validation is required to confirm these effects.
http://www.globalsciencebooks.info/Online/GSBOnline/images/2010/MAPSB_4(1)/MAPSB_4(1)1-4o.pdf – This review provides an overview of Uraria picta's potential uses and phytochemicals. It offers context on the plant's traditional applications and chemical composition. However, it lacks specific data on Uraria picta's effects and serves as a general reference rather than a detailed analysis.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9988554/ – This article discusses the ethnobotanical and pharmacological properties of plants used in traditional medicine. It highlights the potential of Uraria picta as a source of bioactive compounds with various therapeutic applications. The review emphasizes the need for further research to validate these traditional uses and explore the plant's full pharmacological potential.
https://www.sciltp.com/journals/jmnp/article/download/405/317/4140 – This study focuses on the antimicrobial properties of Uraria picta, specifically its activity against methicillin-resistant Staphylococcus aureus (MRSA). The research identifies compounds within the plant extract that contribute to its antibacterial effects. The findings suggest that Uraria picta could be a potential source of novel antimicrobial agents, warranting further investigation into its clinical applications.