Sytrinol
Also known as: Sytrinol, Polymethoxylated Flavones, Naringenin, Citrus Bioflavonoids
Overview
Sytrinol is a patented dietary supplement derived from citrus fruit peels, particularly oranges and tangerines. It contains active compounds such as polymethoxylated flavones (PMFs) and naringenin, both recognized for their powerful antioxidant properties. The main application of Sytrinol lies in promoting cardiovascular health by enhancing lipid profiles; specifically, it has been found effective in lowering total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels, while potentially raising high-density lipoprotein cholesterol (HDL-C). This supplement shows significant effectiveness in patients with hypercholesterolemia by inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in cholesterol synthesis, and also promotes the excretion of bile acids. Despite its promising effects, further research is necessary to validate the long-term health benefits and overall efficacy of Sytrinol.
Benefits
1. Lipid Profile Improvement: Sytrinol has demonstrated statistically significant reductions in total cholesterol (average decrease of 13.4 mg/dL) and LDL-C levels (10.3 mg/dL) in clinical studies (p < 0.001). This supports its use in lipid management, particularly for individuals with hypercholesterolemia. 2. Weight Management: Preliminary studies suggest potential weight loss benefits, but the evidence remains inconclusive and requires more research. 3. Population-Specific Effects: Individuals with hypercholesterolemia have shown notable improvements in LDL-C levels, reinforcing its importance for managing cardiovascular risk in this group. The research quality of these findings is high, contributing to the confidence in Sytrinol's cardiovascular benefits.
How it works
Sytrinol primarily acts by inhibiting the enzyme HMG-CoA reductase, a critical player in cholesterol synthesis in the liver. By reducing cholesterol production, it promotes the increased excretion of bile acids that utilize cholesterol in their synthesis. This dual action effectively aids in regulating cholesterol levels and enhances the overall lipid profile, thereby influencing hepatic cholesterol metabolism.
Side effects
Sytrinol is generally considered safe when utilized according to recommended doses. However, gastrointestinal discomfort, such as nausea, diarrhea, and stomach upset may occur in over 5% of users. Less common side effects (1-5% of users) include headaches, dizziness, and allergic reactions, while rare adverse effects manifest in less than 1% of users. Care should be exercised when Sytrinol is used alongside medications like statins due to potential interactions. Pregnant or nursing women and those with liver conditions should consult healthcare professionals before use, as their safety has not been fully established.
Dosage
The recommended dosage range for Sytrinol aimed at improving lipid profiles is between 300 mg and 600 mg per day, with 300 mg identified as an effective minimum. To optimize absorption and enhance compliance, splitting the daily dosage into two to three servings is recommended, with intake during meals. While an upper limit has not been firmly established, higher doses (over 600 mg) are less frequently studied. Taking Sytrinol with fatty foods is suggested to improve absorption and may help mitigate gastrointestinal side effects.
FAQs
Is Sytrinol safe?
Generally, Sytrinol is considered safe, especially at recommended doses. However, it should be used under medical supervision if you are on medications or have underlying health issues.
When should I take Sytrinol?
It is best taken with meals to minimize side effects and enhance absorption.
How soon can I expect results?
Improvements in lipid profiles are typically observable within several weeks to a few months of starting supplementation.
Can I replace my cholesterol medication with Sytrinol?
Sytrinol is not a replacement for prescribed medications but may serve as a complementary therapy under medical supervision.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601741/ – This systematic review evaluates the effects of Sytrinol on lipid profiles, highlighting significant reductions in total cholesterol and LDL-C levels, which are crucial for cardiovascular health.
- https://pubmed.ncbi.nlm.nih.gov/21660653/ – A clinical trial investigating the impact of Sytrinol supplementation on cholesterol levels, offering insights into its efficacy for those with hypercholesterolemia.
