Supplying Yohimbine
Also known as: Yohimbine hydrochloride, Yohimbe, Pausinystalia yohimbe, Yohimbina, Yohimbine
Overview
Yohimbine is an indole alkaloid extracted from the bark of the yohimbe tree, which is native to Central Africa. It is primarily used for managing erectile dysfunction (ED) and is also investigated for potential applications in weight loss and enhancing athletic performance. As an alpha-2 adrenergic receptor antagonist, yohimbine promotes improved blood flow and exerts stimulant effects. Research supports its efficacy in treating ED, with systematic reviews and meta-analyses confirming its clinical relevance. The most commonly available form is yohimbine hydrochloride, which serves as a viable option for individuals seeking treatments for sexual dysfunction or performance enhancement.
Benefits
Yohimbine exhibits significant efficacy in improving erectile dysfunction. Meta-analyses report an odds ratio of 3.85 (95% CI 2.22-6.67) when compared to placebo. Moreover, acute supplementation potentially enhances athletic performance by improving mean power output and reducing the fatigue index, with results showing robust statistical significance. Though yohimbine alone may not significantly boost sexual function, its synergistic potential with other supplements is noteworthy. Diabetic individuals may experience pronounced benefits, indicating that yohimbine's effectiveness may vary based on specific health conditions.
How it works
Yohimbine acts primarily as an antagonist of alpha-2 adrenergic receptors, leading to increased norepinephrine release and activation of other neurotransmitters. This process enhances blood flow to the genital region, thereby improving erectile function. Additionally, yohimbine stimulates the sympathetic nervous system, resulting in increased peripheral vascular congestion. Despite its good oral bioavailability, further research is required to better understand specific absorption details.
Side effects
Generally safe when used appropriately, yohimbine can cause side effects such as anxiety, insomnia, and an increase in heart rate (over 5%). Less frequent side effects may include dizziness, nausea, and tremors (1-5%), with rare cases (<1%) of severe allergic reactions. Caution is recommended when combining yohimbine with cardiovascular medications or stimulants due to potential interactions. It is contraindicated for individuals with hypertension, heart disease, or psychological disorders, as yohimbine may exacerbate these conditions. Elderly populations and those with liver or kidney issues should take special care.
Dosage
For erectile dysfunction, recommended dosages of yohimbine range from 5.4 to 10.8 mg per day. Athletic performance enhancement dosages are less clearly defined, but generally suggested to be between 0.2 to 1 mg/kg of body weight. Although no maximum safe dosage is firmly established, doses should typically not exceed 10 mg daily to avoid potential adverse effects. Timing is crucial, with yohimbine ideally taken 1-2 hours before sexual activity and 30-60 minutes prior to physical exercise. Food consumption can affect absorption, and this should be taken into account when planning dosage schedules.
FAQs
Is yohimbine safe?
Yohimbine is generally safe; however, it may cause side effects like anxiety and increased heart rate, especially in individuals with pre-existing conditions.
When should I take yohimbine?
For optimal effects, take yohimbine 1-2 hours before sexual activity or 30-60 minutes before exercise.
What results can I expect from using yohimbine?
Yohimbine can improve erectile function and may enhance athletic performance, though effectiveness varies among individuals.
Can yohimbine cure erectile dysfunction?
Yohimbine is not a cure-all for erectile dysfunction; its effectiveness may increase when used alongside other supportive treatments.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000035/ – This systematic review examines the effects of yohimbine on erectile dysfunction, concluding that it significantly improves outcomes compared to placebo with favorable odds ratios across multiple studies.
- https://pubmed.ncbi.nlm.nih.gov/16070308/ – A meta-analysis that discusses yohimbine's role in enhancing athletic performance reveals statistically significant improvements in power output and reduction of fatigue, supporting its use among athletes.
- https://www.sciencedirect.com/science/article/pii/S0002934319375406 – This article reviews the biological mechanisms of yohimbine and its interactions with adrenergic receptors, providing insights into its potential therapeutic applications in various conditions, including sexual dysfunction.
Supplements Containing Supplying Yohimbine

Nanostim
MuscleTech Concentrated Series

Hydroxycut SX-7
MuscleTech

Hydroxycut SX-7 Fruit Punch Fusion
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Hydroxycut SX-7 Blue Raspberry Blast
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Nano Vapor Hardcore Pre-Workout Formula Sour Apple
MuscleTech Performance Series

Hydroxycut Hardcore Next Gen
MuscleTech Performance Series
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