ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Benfotiamine

Also known as: S-{(Z)-2-{(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino}-5-phosphonooxypent-2-en-3-yl}benzenecarbothioate, Sulbutiamine

Overview

Benfotiamine is a relative of the vitamin Thiamine (B1) that appears to have a therapeutic role in pain reduction and diabetic complications (neuropathies and nephropathies); confers bioavailable Vitamin B1 after oral ingestion.

Benefits

Benfotiamine functions in the body by converting into thiamine, which is essential for carbohydrate metabolism and nerve function. It helps to reduce the formation of advanced glycation end products (AGEs), which are harmful compounds that can contribute to diabetic complications.

How it works

Benfotiamine is most often used for pain relief and has been linked to several benefits including reducing symptoms of diabetic neuropathy, improving nerve function, and potentially lowering blood sugar levels in diabetic patients.

Side effects

Benfotiamine is commonly taken at the oral dose of 300-600mg over the course of the day, usually in two divided doses with meals (150mg or 300mg twice daily).

Dosage

Benfotiamine is generally considered safe, but some individuals may experience mild side effects such as gastrointestinal discomfort or allergic reactions. It is important to consult a healthcare provider before starting any new supplement, especially for those with existing health conditions or those taking other medications.

FAQs

What is Benfotiamine?

Benfotiamine is a fat-soluble derivative of thiamine (vitamin B1) that is used to help manage diabetic complications and pain.

How should I take Benfotiamine?

Benfotiamine is typically taken in doses of 300-600mg per day, divided into two doses with meals.

Are there any side effects of Benfotiamine?

Benfotiamine is generally well-tolerated, but some may experience mild side effects such as gastrointestinal issues.

Can I take Benfotiamine with other medications?

It is advisable to consult a healthcare professional before combining Benfotiamine with other medications.

Supplements Containing Benfotiamine

Super Carnosine 500 mg by Life Extension
65

Super Carnosine 500 mg

Life Extension

Score: 65/100
Benfotiamine by XYMOGEN
83

Benfotiamine

XYMOGEN

Score: 83/100
Neuro Enhancer by Bronson Laboratories
70

Neuro Enhancer

Bronson Laboratories

Score: 70/100
Benfotiamine With Coenzyme B1 150 mg by Country Life
78

Benfotiamine With Coenzyme B1 150 mg

Country Life

Score: 78/100
IC-5 by BioTrust
68

IC-5

BioTrust

Score: 68/100
B Activ by XYMOGEN
70

B Activ

XYMOGEN

Score: 70/100
Benfotiamine by XYMOGEN
88

Benfotiamine

XYMOGEN

Score: 88/100
Healthy Blood Sugar by Terry Naturally
75

Healthy Blood Sugar

Terry Naturally

Score: 75/100