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Standardized Schisandra Extract

Also known as: Omija, Five-Flavor Berry, Chinese Magnolia Vine, *Schisandra chinensis* (Turcz.) Baill.

Overview

Schisandra chinensis is a medicinal plant native to East Asia, particularly in China, Korea, and Russia. It produces small red berries that are utilized extensively in traditional medicine, primarily for enhancing physical performance and cognitive clarity. Modern studies have shown its potential anti-inflammatory, antioxidant, and anti-diabetic properties, attributed to its diverse bioactive compounds such as lignans (including schisandrin and schisandrol A), flavonoids, and polysaccharides. Research indicates a moderate maturity level, combining several animal and human studies, although there remains a need for more rigorous clinical trials to elucidate its safety and effectiveness. Currently available evidence suggests therapeutic applications in holistic health practices, particularly in improving metabolic health and supporting cognitive function.

Benefits

Clinical investigations highlight several evidence-based benefits of *Schisandra chinensis* extract. Notably, it has been observed to improve glycemic control, with a randomized controlled trial indicating a significant mean reduction in fasting plasma glucose of -5.62 mg/dL after 12 weeks of supplementation at a dose of 500 mg/day. Additionally, the extract was associated with reduced LDL-cholesterol levels, suggesting cardiovascular benefits. Further research has delineated the extract's anti-inflammatory and antioxidant properties, demonstrating its capacity to modulate crucial signaling pathways involved in these processes. The extract also shows promise as a neuroprotective agent, particularly in models resembling osteoarthritis and type 2 diabetes; however, the quality of studies varies, necessitating further research to corroborate these findings.

How it works

The mechanisms through which *Schisandra chinensis* exerts its therapeutic effects involve the regulation of pivotal biological pathways, notably MAPK and NF-κB signaling, which play crucial roles in inflammation and oxidative stress response. By modulating these pathways, the extract may help alleviate chronic inflammatory conditions and enhance antioxidant defenses. Additionally, the extract's components demonstrate neuroactive properties, suggesting interactions with neurotransmitter systems that may contribute to its cognitive benefits as well. However, the bioavailability of its active compounds remains variable depending on extraction methods, although specific absorption data is limited.

Side effects

Generally considered safe, *Schisandra chinensis* has limited documented side effects, although gastrointestinal symptoms may occur in some individuals due to its herbal composition. Currently, no significant rare side effects have been reported, though caution is advised for pregnant or breastfeeding women due to insufficient research on long-term safety in these populations. Drug interactions may arise, particularly with antidiabetic medications and other herbal extracts, emphasizing the importance of monitoring blood glucose levels closely for diabetic patients. No distinct contraindications exist, but awareness of hormonal effects, especially in post-menopausal women, is recommended. Rigorous long-term studies are needed to fully assess and confirm the safety profile of the extract.

Dosage

The optimal dosage of *Schisandra chinensis* is not precisely established, but existing research suggests a minimum effective dose of 500 mg/day, particularly noted for glycemic and lipid control benefits. While common dosages range from 500 mg to 1 gram per day, there is no defined upper limit for safety, provided that doses within this range do not yield significant adverse reactions. It is generally advisable to consume the supplement with meals to enhance absorption. Variations in product formulation, such as capsules or powders, may influence absorption characteristics, although detailed data on these factors remain limited and warrant consideration.

FAQs

What are the safety concerns associated with *Schisandra chinensis*?

While generally considered safe, limited research on long-term safety exists. It is important to monitor diabetes medications for interactions and consult healthcare providers before use.

When is the best time to take *Schisandra chinensis*?

It is recommended to take the supplement with meals to enhance absorption, but the timing is not critically defined.

What improvements can I expect from taking this extract?

Users can typically expect benefits in glycemic control and lipid profiles, along with potential anti-inflammatory and cognitive enhancements.

Is *Schisandra chinensis* a substitute for medical treatment?

No, this extract should not replace prescribed medical treatments but can be considered a complementary therapy under medical supervision.

Research Sources

https://www.mdpi.com/2072-6643/14/15/3159 – This randomized controlled trial assessed the efficacy and safety of *Schisandra chinensis* extract in improving glycemic control and lipid profiles. Results indicated significant improvements in the treatment group compared to placebo after 12 weeks.
https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.17814 – An animal study exploring the effects of *Schisandra chinensis* on osteoarthritis demonstrated its ability to inhibit cartilage destruction through regulation of key inflammatory pathways, suggesting therapeutic potential.
https://www.mdpi.com/1660-4601/17/7/2475/review_report – This review critically examined existing studies on *Schisandra chinensis*, highlighting the need for improved quality control in extracts and more rigorous clinical trials to support its therapeutic claims.