Sodium Creatine Phosphate Matrix
Also known as: phosphocreatine sodium, Creatine phosphate sodium, Sodium Creatine Phosphate
Overview
Sodium Creatine Phosphate, also known as phosphocreatine sodium, is a high-energy phosphate compound naturally present in muscle and heart tissues. It serves as a rapid reserve for regenerating ATP, the primary cellular energy currency, especially during periods of high energy demand. Synthetically produced for supplementation, it is primarily used to enhance energy metabolism in cardiac and skeletal muscles. While clinically investigated for conditions like viral myocarditis, its application in sports nutrition is less established compared to creatine monohydrate. Research indicates its ability to act as a phosphate donor, rapidly regenerating ATP, and it is categorized as an energy metabolism enhancer or phosphagen compound.
Benefits
Sodium Creatine Phosphate has demonstrated significant benefits primarily in patients with viral myocarditis. A 2025 systematic review and meta-analysis of 9 RCTs (n=1,116 patients) showed it significantly improved the overall efficacy rate compared to control (Risk Ratio [RR] = 1.22, 95% CI 1.15–1.28, p<0.00001). It also led to significant reductions in cardiac injury biomarkers, including cardiac troponin I (MD = 0.1, 95% CI 0.07–0.13, p<0.00001) and creatine kinase isoenzyme (MD = 9.43, 95% CI 7.04–11.82, p<0.00001). These findings suggest a robust improvement in clinical outcomes and myocardial injury markers, indicating meaningful cardiac protection or recovery. Importantly, the meta-analysis found no significant increase in adverse reactions compared to controls (RR = 1.07, 95% CI 0.68–1.67, p=0.77). The benefits are most evident in cardiac patients, with potential for improving cardiac muscle energy metabolism.
How it works
Sodium Creatine Phosphate functions as a crucial phosphate donor within the cell, rapidly transferring its phosphate group to adenosine diphosphate (ADP) to regenerate adenosine triphosphate (ATP). This process is facilitated by the creatine kinase enzyme system, which reversibly transfers phosphate groups between ATP and creatine phosphate. By maintaining high levels of ATP, the compound supports energy-demanding processes in cardiac and skeletal muscle cells, stabilizing cellular energy homeostasis, particularly during stress or injury. The sodium salt form is believed to enhance its solubility and bioavailability, contributing to its effectiveness in supporting cellular energy metabolism.
Side effects
Sodium Creatine Phosphate is generally considered safe, with clinical trials in myocarditis showing no significant difference in adverse events compared to control groups. No common (over 5%), uncommon (1-5%), or rare (under 1%) side effects have been notably reported in meta-analyses. Specific drug interactions are not well characterized, so caution is advised when co-administering with other cardiac medications. Contraindications are not definitively established but may align with other creatine derivatives, suggesting caution in individuals with renal impairment or unstable cardiac conditions. Safety data is primarily derived from adult cardiac patients, and its safety in children, pregnant women, or athletes is not well-established.
Dosage
Optimal dosage ranges for Sodium Creatine Phosphate are not yet standardized, as clinical studies have utilized varied dosing regimens tailored to specific cardiac treatment protocols. In the context of myocarditis, it is typically administered during the acute or subacute phases of treatment, often via intravenous routes in clinical settings due to the enhanced solubility of the sodium salt form. While no maximum safe dose has been defined, no dose-limiting toxicities have been reported in meta-analyses. Oral bioavailability and efficacy require further research, as most clinical evidence stems from intravenous administration. No specific cofactors are identified as required for its efficacy.
FAQs
Is Sodium Creatine Phosphate the same as Creatine Monohydrate?
No, Sodium Creatine Phosphate is a phosphorylated form with a sodium salt, primarily used for cardiac energy metabolism, unlike creatine monohydrate which is a general sports supplement.
Is it safe for athletes?
Limited direct evidence exists for its safety and efficacy in athletes; most research focuses on its use in cardiac patients.
How quickly does it work?
Clinical improvements in myocarditis patients have been observed within days to weeks of treatment initiation.
Can it cause kidney damage?
Current meta-analyses do not show evidence of kidney damage; however, caution is generally advised with creatine derivatives, especially in individuals with pre-existing renal issues.
Is oral supplementation effective?
Clinical studies often use intravenous forms. The bioavailability and efficacy of oral Sodium Creatine Phosphate require more research.
Research Sources
- https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0317498 – This systematic review and meta-analysis of 9 RCTs (n=1,116) on viral myocarditis found that Sodium Creatine Phosphate significantly improved overall efficacy and reduced cardiac injury markers (cTnI, CK-MB) without increasing adverse events. It provides strong evidence for its clinical utility in this specific patient population.
- https://pubmed.ncbi.nlm.nih.gov/39854433/ – This PubMed entry corresponds to the same meta-analysis by Wang et al., 2025, highlighting its findings on the efficacy and safety of Sodium Creatine Phosphate in treating viral myocarditis. It reinforces the positive clinical outcomes observed.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11268231/ – This systematic review and meta-analysis on creatine supplementation generally found benefits for muscle mass and strength in healthy adults. While not specific to Sodium Creatine Phosphate, it provides broader context on creatine's role, though direct evidence for this specific form in sports is limited.
- https://ouci.dntb.gov.ua/en/works/4vnbW1V4/ – This source likely refers to foundational biochemical studies or reviews, such as those by Bessman & Mohan (1992), which describe the fundamental biochemical role of phosphocreatine in energy metabolism and cardiac function. It provides the mechanistic basis for Sodium Creatine Phosphate's action.
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