Sicilian Red Orange Extract
Also known as: Red Orange Extract, Sicilian Red Orange, Sicilian Red Orange Extract, Moro orange extract, Tarocco orange extract, Sanguinello orange extract, Citrus sinensis extract
Overview
Sicilian Red Orange Extract is derived from pigmented *Citrus sinensis* varieties, specifically Moro, Tarocco, and Sanguinello oranges grown in Sicily. These oranges are rich in anthocyanins, flavanones, hydroxycinnamic acids, and ascorbic acid, contributing to the extract's antioxidant and photoprotective properties. As a dietary supplement, it is primarily used for its antioxidant, anti-inflammatory, and photoprotective effects. The extract's high anthocyanin content, particularly cyanidin-3-glucoside, is a key characteristic responsible for its health benefits. Research on Sicilian Red Orange Extract is considered moderate, with several in vivo and in vitro studies supporting its efficacy, although more systematic reviews are needed to fully understand its comprehensive health impacts. It is available in various forms, most commonly as capsules, and is sourced directly from the fruit.
Benefits
The primary benefits of Sicilian Red Orange Extract include photoprotection against UV-induced erythema and improvement in skin antioxidant capacity, supported by studies showing significant improvements in skin health parameters after supplementation. It also exhibits anti-inflammatory and cardiovascular protective effects, attributed to its high antioxidant content. Studies have demonstrated its effectiveness in both Asian and Caucasian populations for photoprotection. Supplementation over 56 days has shown clinically significant improvements in skin health parameters. The extract may also reduce oxidative stress and improve skin health parameters such as moisturization and elasticity.
How it works
Sicilian Red Orange Extract exerts its effects primarily through its antioxidant activity. The anthocyanins and polyphenols in the extract scavenge free radicals and inhibit lipid peroxidation, reducing oxidative stress. Specifically, anthocyanins like cyanidin-3-glucoside interact with cellular components to mitigate oxidative damage. The extract primarily affects the skin and cardiovascular systems. Bioavailability studies have shown that anthocyanins from red orange juice are absorbed into the bloodstream, increasing plasma levels of these beneficial compounds after consumption.
Side effects
Sicilian Red Orange Extract is generally considered safe when consumed in typical dietary amounts. Common side effects are not well-documented, but some individuals may experience mild gastrointestinal upset. Allergic reactions are possible but rare. There are potential interactions with blood thinners due to the flavonoid content, although evidence is limited. Caution is advised for individuals with citrus allergies. Pregnant or breastfeeding women should consult healthcare providers before using this supplement. No rare side effects have been reported in the available literature.
Dosage
The minimum effective dose of Sicilian Red Orange Extract for photoprotection is 100 mg per day, as demonstrated in clinical studies. While optimal dosage ranges are not definitively established, 100 mg/day is a common and effective dose for photoprotective effects. The maximum safe dose has not been defined, but typical dietary intake is generally considered safe. It is recommended to take the supplement after breakfast to enhance bioavailability. The capsule form is commonly used. Bioavailability may be enhanced with food intake. There are no documented required cofactors for its use.
FAQs
Is Sicilian Red Orange Extract safe?
It is generally safe, but monitor for allergic reactions or gastrointestinal upset. Consult a healthcare provider if you have concerns.
When is the best time to take it?
It is best taken with breakfast to enhance bioavailability and absorption of its active compounds.
What results can I expect?
You can expect improved skin health and photoprotection within a few weeks of consistent supplementation.
Can it replace sunscreen?
No, it is not a substitute for sunscreen. Use it in conjunction with other sun protection methods for optimal results.
Should I consult a healthcare provider before use?
Yes, it is recommended to consult a healthcare provider before starting any new supplement regimen, especially if you have existing health conditions.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9182634/ – A randomized, double-blind, controlled study (n=110) found that 100 mg/day of Sicilian Red Orange Extract improved skin photoprotection and antiaging parameters over 56 days. The study highlights the potential of the extract in enhancing skin health and reducing the effects of photoaging.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3659473/ – This review discusses the potential health benefits of red orange juice consumption, including increased plasma antioxidant capacity and improved cardiovascular risk factors. The review suggests that the anthocyanins and other compounds in red orange juice contribute to these beneficial effects.
- https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/4week-consumption-of-anthocyaninrich-blood-orange-juice-does-not-affect-ldlcholesterol-or-other-biomarkers-of-cvd-risk-and-glycaemia-compared-with-standard-orange-juice-a-randomised-controlled-trial/D35E01BAC0C82E4206A1155BD84CD8D6 – A randomized controlled trial (n=42) found that anthocyanin-rich blood orange juice did not affect LDL-cholesterol levels but may have other cardiovascular benefits. The study indicates that while it may not directly impact LDL-cholesterol, other components could contribute to cardiovascular health.
- https://pubs.acs.org/doi/abs/10.1021/jf0485234 – This study investigates the bioavailability of anthocyanins from red orange juice, demonstrating increased plasma levels of these compounds after consumption. The findings support the absorption and potential systemic effects of anthocyanins from red orange juice.
- https://www.sciencedirect.com/science/article/pii/S2161831322005324 – This research explores the protective effects of red orange extract against UVB-induced damage in keratinocytes. The study suggests that the extract can mitigate oxidative stress and inflammation caused by UVB radiation, supporting its photoprotective properties.
