ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Sicilian Blood Orange Fruit And Peel Extract

Also known as: Sicilian Blood Orange, Blood Orange, Citrus x sinensis, Citrus sinensis (Sicilian Blood Orange)

Overview

The Sicilian Blood Orange is a distinctive citrus variety recognized for its vivid red to reddish-purple flesh, primarily due to the high concentration of anthocyanins. Extracts from both the fruit and peel are gaining attention for their strong antioxidant effects and potential cardiovascular health benefits. Rich in bioactive compounds such as flavonoids, carotenoids, and limonoids, these extracts may help combat oxidative stress linked to various chronic health conditions. Preliminary research suggests a range of health benefits associated with Sicilian Blood Orange extract, although further studies are warranted to clarify its efficacy compared to other citrus variants. Available in multiple forms including fresh juice, concentrated supplements, and powders, it is a popular addition to wellness routines focused on overall health improvement.

Benefits

Sicilian Blood Orange extract is particularly noted for its potent antioxidant properties and its contributions to cardiovascular health. Clinical studies indicate that blood orange juice consumption can significantly reduce systolic blood pressure and improve lipid profiles, especially in healthy aging adults. Research published in the American Journal of Clinical Nutrition highlights these cardiovascular benefits as particularly advantageous for the elderly, largely due to the extract’s anti-inflammatory and antioxidant properties. Additionally, studies from the Journal of Agricultural and Food Chemistry show that blood orange juice exhibits superior antioxidant activity compared to other citrus fruits. Despite these encouraging findings, more rigorous research is needed for full validation of these health benefits.

How it works

The beneficial effects of Sicilian Blood Orange extract are mainly attributed to its bioactive components, particularly anthocyanins and flavonoids. These compounds help reduce oxidative stress and inflammation by modulating critical enzymes involved in inflammatory pathways, such as cyclooxygenase-2 (COX-2) and NADPH oxidase. Furthermore, the extract improves endothelial function and lipid metabolism, promoting cardiovascular health. The bioavailability of these compounds is considered moderate to high, especially when consumed in juice or concentrated forms, and their absorption may be enhanced when taken with dietary fats.

Side effects

Sicilian Blood Orange extract is generally regarded as safe when consumed at typical dietary levels, with significant side effects being rare. Some individuals may experience mild gastrointestinal disturbances if larger amounts are ingested. Allergic reactions are uncommon but can occur, particularly in those who have sensitivities to citrus fruits. Caution is advised for individuals taking anticoagulant medications due to the vitamin C content, which may affect clotting processes. Furthermore, individuals with known citrus allergies or those scheduled for surgery are recommended to consult a healthcare provider prior to use. Pregnant or breastfeeding women should also seek professional guidance before initiating supplementation, as a precautionary measure.

Dosage

The typical recommended dosage of Sicilian Blood Orange extract ranges from 500 mg to 2 grams per day. Commonly, consuming 1 to 2 cups of blood orange juice or its concentrated equivalent daily is advised to support cardiovascular health. Although a specific upper limit for supplementation has not been established, it is prudent to approach doses above 5 grams daily with caution due to insufficient safety data at those higher levels. There is no critical timing for consumption; however, consistent daily intake is encouraged to maximize health benefits. The extract is most frequently available in juice or concentrated forms, with absorption improved when consumed with dietary fats.

FAQs

How often should I take it?

Daily consumption is recommended for consistent results in benefits.

Is it safe for everyone?

Generally safe, but consult a healthcare professional if you have allergies or specific health conditions.

What are the expected results?

Anticipated benefits include improved antioxidant status and potential enhancements in cardiovascular health markers.

Can I take it with other supplements?

It is generally safe to combine with other supplements, but checking with a healthcare provider is advised.

When should I take it?

No specific timing is required; consistent daily use is advisable.

Research Sources

  • https://academic.oup.com/ajcn/article/104/5/1419/4558289 – This study published in the American Journal of Clinical Nutrition discusses the cardiovascular benefits associated with the consumption of blood orange products, highlighting significant reductions in systolic blood pressure in aging populations.
  • https://pubs.acs.org/doi/abs/10.1021/jf040136y – Research from the Journal of Agricultural and Food Chemistry demonstrates that blood orange juice possesses superior antioxidant activity compared to other citrus fruits, emphasizing its potential role in combating oxidative stress.