Sibelius Sage Extract
Also known as: Sage, Common Sage, Garden Sage, Spanish Sage, Salvia officinalis
Overview
Salvia officinalis, commonly known as sage, is a Mediterranean herb renowned for its historical significance in culinary and traditional medicinal practices. This herb has garnered attention in modern research for its potential health benefits, particularly its cognitive-enhancing effects and anti-inflammatory properties. Sage extracts are typically standardized to ensure consistency, particularly in their concentrations of bioactive compounds, most notably rosmarinic acid. Studies have shown that sage can improve cognitive function, particularly memory and mood regulation, backed by a moderate body of human and in vitro research. Despite promising findings, comprehensive systematic reviews are limited, indicating a need for further research to fully grasp its long-term effects and potentials in various populations.
Benefits
Sage extract boasts several evidence-backed benefits, chiefly its positive impact on cognitive performance, particularly in short-term episodic memory. A double-blind, placebo-controlled study identified significant improvements in young adults with dosages of 150 mg and 300 mg. The extract also exhibits notable anti-inflammatory effects, indicated by a reduction in cytokine release in human cell lines. Secondary benefits include mood enhancement and neurotransmitter modulation, which may vary based on the dosage used. Young adults demonstrate pronounced cognitive improvements, while older adults may also benefit. The observed effect sizes suggest moderate clinical significance, although additional research is required to establish the long-term implications of sage supplementation.
How it works
Sage extract enhances cognitive function primarily by inhibiting acetylcholinesterase (AChE), leading to increased levels of acetylcholine that facilitate memory improvement. Furthermore, it plays a role in modulating inflammatory cytokine release, offering anti-inflammatory effects in various cells. Sage also influences monoamine neurotransmitter metabolism by inhibiting enzymes such as catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), potentially affecting dopamine and serotonin levels and thus mood regulation.
Side effects
Sage extract is generally recognized as safe when consumed within recommended dosages, with clinical studies reporting no significant adverse events. Common side effects are largely negligible, and there are no documented uncommon or rare adverse effects in the reviewed research. However, caution is advised for pregnant or breastfeeding women due to limited safety data. Additionally, potential interactions with cholinergic and monoaminergic medications warrant careful attention. Overall, sage has a positive safety profile, but ongoing research into its long-term effects and potential interactions is essential to ensure comprehensive understanding and safety.
Dosage
The effective dosage range for standardized *S. officinalis* extract is established at a minimum of 150 mg, which provides notable cognitive benefits. Optimal dosages for acute effects range from 150 mg to 300 mg, according to clinical trials indicating efficacy within these parameters. Although a maximum safe dose has not been conclusively established, studies suggest safety up to 300 mg without reported adverse effects. Acute benefits are typically observed within hours of administration. For standardized aqueous-ethanolic extracts, it is recommended to contain at least 2.5% w/w rosmarinic acid, as bioavailability may vary with different extraction methods.
FAQs
Is sage extract safe?
Yes, sage extract is generally considered safe at studied doses, but long-term safety and potential medication interactions require further investigation.
When should I take sage extract?
Acute effects can be observed shortly after administration, but optimal timing for chronic use has not been clearly established.
What results can I expect?
Users may experience improvements in short-term episodic memory and possible mood enhancements.
Are there misconceptions about sage extract?
Sage extract is not a cure for cognitive decline but may provide supportive cognitive benefits.
