Schizonepeta Aerial Part Extract
Also known as: Japanese Catnip, Schizonepeta, Jing Jie, *Schizonepeta tenuifolia*
Overview
*Schizonepeta tenuifolia* is a plant native to East Asia, predominantly used in traditional Chinese medicine. The aerial parts are extracted for their bioactive compounds, which include flavonoids, terpenoids, and phenolic acids. The extract is known for its anti-inflammatory, antipyretic, and antiallergic properties. While historically used for various ailments, such as fever and allergic reactions, modern research is still emerging. Evidence primarily stems from animal and in vitro studies, with fewer human trials available to confirm its efficacy in treating these conditions.
Benefits
The extract has documented benefits including: 1) **Anti-inflammatory Effects**: Reduction of inflammation in animal models with significant inflammatory marker reduction (p < 0.01) [1]. 2) **Antiallergic Effects**: Inhibition of histamine release from mast cells in vitro supporting its role for allergy sufferers [2]. 3) **Antipyretic Effects**: Traditional uses suggest effectiveness in reducing fever, supported by animal studies showing fever reduction in rats (p < 0.05) [3]. Populations most likely to benefit include those with allergic reactions and inflammatory conditions, though further human research is essential.
How it works
The mechanism of action involves inhibition of inflammatory cytokines and mediators, such as TNF-α and IL-1β, alongside antioxidant activity. It modulates the immune system and interacts with the hypothalamic-pituitary-adrenal axis for antipyretic effects. The extract may also inhibit histamine release from mast cells, thereby exhibiting antiallergic properties.
Side effects
Overall, *Schizonepeta tenuifolia* is considered safe based on traditional use and animal studies, with no common side effects reported (>5%). Some animal studies noted gastrointestinal discomfort (1-5%). No rare side effects (<1%) have been documented. Caution is advised when combined with immunosuppressive drugs due to its immunomodulatory effects or anticoagulants due to potential antiplatelet activity. It is contraindicated in pregnancy and breastfeeding due to insufficient safety data. Elderly individuals should be cautious due to possible drug interactions. There is no data available on its effects in children.
Dosage
The minimum effective dose for humans has not been established; however, animal studies suggest dosages ranging from 100-500 mg/kg body weight. No clear optimal human dosage is available, and high doses in animal studies did not lead to significant toxicity. Common forms include capsules or powders, and absorption may be enhanced with fatty meals. There are no specified timing recommendations or required cofactors identified.
FAQs
Is *Schizonepeta tenuifolia* safe?
Generally safe based on traditional use, but human trials are needed for thorough evaluation.
What are the recommended dosages?
There are no established dosages for humans; animal studies suggest ranges of 100-500 mg/kg.
What benefits can I expect?
Potential benefits include reduced inflammation and allergic reactions based on animal studies.
Can it replace medical treatment?
It should not substitute medical treatment; consult a healthcare provider before use.
Research Sources
- https://www.sciencedirect.com/science/article/abs/pii/S0378874111003834 – This study evaluates the anti-inflammatory effects of *Schizonepeta tenuifolia* extract in mice, showing significant reductions in inflammatory markers, underscoring its potential in treating inflammatory conditions.
- https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.906 – An in vitro study demonstrating the antiallergic activity of *Schizonepeta tenuifolia* extract through inhibition of histamine release from mast cells, providing a basis for its traditional use in allergy treatment.
- https://www.liebertpub.com/doi/full/10.1089/jmf.2010.1358 – This research analyzes the antipyretic effects of the extract in rats, highlighting its ability to reduce fever as evidenced by statistically significant results.
