Sage Root Extract
Also known as: Salvia miltiorrhiza, Chinese Sage, Red Sage, Danshen, Sage Root Extract
Overview
Salvia miltiorrhiza, commonly known as Chinese Sage or Danshen, is a plant native to China and Japan, with its root being used medicinally. It is important to distinguish it from *Salvia officinalis*, the common sage. The root extract contains compounds like tanshinones and salvianolic acids, believed to contribute to its medicinal properties. Traditionally, it has been used to support cardiovascular health and improve circulation. Recent research explores its potential effects on lower urinary tract symptoms (LUTS) and kidney function. While clinical trials are increasing, more systematic reviews are needed to fully establish its efficacy and safety. The quality of available evidence is variable, with some high-quality clinical trials but a need for more comprehensive analyses.
Benefits
Salvia miltiorrhiza has shown promise in improving symptoms of lower urinary tract symptoms (LUTS) and enhancing erectile function. Studies have demonstrated statistically significant improvements in the International Prostate Symptom Score (IPSS) and International Index of Erectile Function (IIEF) scores within a 12-week treatment period. Additionally, it may improve kidney function by reducing serum creatinine and increasing creatinine clearance, potentially benefiting individuals with chronic kidney disease. These benefits are supported by clinical trials, though further research is needed to confirm these findings and determine the optimal dosage and duration of treatment.
How it works
The proposed mechanisms of action for Salvia miltiorrhiza include antioxidant, anti-inflammatory, and vasodilatory effects. It is believed to interact with the cardiovascular and urinary systems. The tanshinones and salvianolic acids present in the extract may target various cellular pathways, although specific targets are not yet well-defined. While limited data exists on its bioavailability, it is thought that the compounds are absorbed and metabolized by the liver, contributing to its systemic effects.
Side effects
Salvia miltiorrhiza is generally considered safe with minimal side effects reported in clinical trials. Commonly, mild gastrointestinal symptoms may occur. Due to its antiplatelet effects, there is a potential for interactions with anticoagulants. It is contraindicated in pregnancy and breastfeeding due to a lack of safety data. Caution is advised in patients with bleeding disorders. While uncommon and rare side effects are not specifically documented, it is important to monitor for any adverse reactions and consult with a healthcare provider if any concerns arise.
Dosage
The minimum effective dose for Salvia miltiorrhiza in treating LUTS symptoms is 400 mg/day. Optimal dosage ranges from 400 mg to 800 mg/day. While the maximum safe dose has not been definitively established, doses up to 800 mg/day have been used without significant adverse effects in studies. It is typically administered orally on a daily basis, with capsules or tablets being common forms. While specific data is lacking, food intake may influence bioavailability. No specific cofactors are documented as required for its efficacy.
FAQs
Should I consult a healthcare provider before using Sage Root Extract?
Yes, it is important to consult a healthcare provider before using Sage Root Extract, especially if you are taking other medications or have pre-existing health conditions, to ensure it is safe for you.
Is Sage Root Extract safe to use?
Sage Root Extract is generally considered safe, but it's important to monitor for potential interactions with other medications, particularly anticoagulants, and to discontinue use if any adverse reactions occur.
How should I take Sage Root Extract?
Take Sage Root Extract daily as directed by your healthcare provider or according to the product label. Improvements in LUTS symptoms and erectile function may be observed within a few weeks of consistent use.
Is Sage Root Extract a substitute for medical treatment?
No, Sage Root Extract is not a substitute for medical treatment. Consult a healthcare provider for appropriate medical care and to determine if Sage Root Extract is a suitable addition to your treatment plan.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11723278/ – This multicenter RCT evaluated Salvia miltiorrhiza root extract (SAGX) for LUTS and showed significant improvements in IPSS and IIEF scores compared to placebo. The study reported no serious adverse events, suggesting that SAGX is a safe and potentially effective treatment for LUTS. The findings support the use of SAGX as a complementary therapy for improving urinary and sexual function in men.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6686118/ – This systematic review of qualitative studies explores the experiences of patients using herbal medicine. It highlights the importance of understanding patient perspectives and the need for healthcare providers to engage in open communication about herbal medicine use. The review emphasizes the potential benefits and risks associated with herbal medicine and the need for rigorous research to establish efficacy and safety.
- https://onlinelibrary.wiley.com/doi/10.1155/2022/2117433 – This meta-analysis on Salvia miltiorrhiza for chronic kidney disease found improvements in kidney function markers such as serum creatinine and creatinine clearance. The study suggests that Salvia miltiorrhiza may have a beneficial effect on kidney function in patients with chronic kidney disease. However, the authors note that more high-quality studies are needed to confirm these findings and determine the optimal dosage and duration of treatment.
- https://www.science.gov/topicpages/q/qualitative+literature+review – This science.gov page provides resources and information on qualitative literature reviews. Qualitative literature reviews are used to synthesize and interpret findings from qualitative studies, providing insights into complex phenomena and patient experiences. These reviews are valuable for understanding the context and meaning of research findings, but they do not provide quantitative data on efficacy or safety.
- https://journals.sagepub.com/doi/10.1177/2515690X20967323 – This article discusses the importance of evidence-based practice in integrative medicine. It highlights the need for rigorous research to evaluate the efficacy and safety of integrative therapies, including herbal medicine. The article emphasizes the importance of using systematic reviews and meta-analyses to synthesize evidence and inform clinical decision-making in integrative medicine.
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