Satiereal Bark Extract
Also known as: Satiereal, saffron stigma extract, Crocus sativus L. extract
Overview
Satiereal is a proprietary extract derived from the stigmas of Crocus sativus (saffron), specifically standardized for its bioactive compounds. It is primarily marketed and studied for its potential to influence satiety, reduce snacking behavior, and aid in weight management. While its main focus is appetite control, some evidence also suggests mood-enhancing effects. Satiereal is distinct from general saffron supplements due to its standardized extraction process, typically dosed at 176.5 mg/day in clinical studies. The research on Satiereal is moderate, with a limited number of randomized controlled trials (RCTs) specifically on this extract, though broader saffron research exists. The evidence is emerging, with some well-designed RCTs, but comprehensive systematic reviews or meta-analyses exclusively on Satiereal are still lacking.
Benefits
Satiereal has demonstrated several evidence-based benefits, primarily in mildly overweight, healthy adult women. A well-conducted randomized controlled trial showed that Satiereal supplementation (176.5 mg/day) significantly reduced snacking frequency compared to placebo, indicating its role in appetite control. The same study also reported a statistically significant greater body weight reduction in the Satiereal group over an 8-week period. Participants reported enhanced feelings of fullness, which likely contributed to the reduced snacking. While not conclusively demonstrated, possible mood-improving effects are hypothesized to contribute to reduced stress-related eating. The weight loss effect was statistically significant but modest, and these findings require further replication across diverse populations and larger studies. Benefits were observed over an 8-week supplementation period.
How it works
Satiereal is believed to exert its effects primarily through the modulation of neurotransmitters involved in appetite regulation, particularly the serotonin pathways. Serotonin is a key neurotransmitter that influences feelings of satiety and mood. By potentially modulating serotonin levels or its reuptake, Satiereal may interact with the central nervous system's appetite control centers, leading to increased feelings of fullness and reduced desire for snacking. This mechanism could also contribute to its hypothesized mood-enhancing effects, thereby reducing stress-induced eating. While the specific molecular targets are not fully elucidated, the primary action is thought to involve serotonin pathway modulation. The extract is designed for oral administration, but specific details on its bioavailability are not well characterized.
Side effects
Satiereal has generally shown a good tolerability profile in clinical trials, with no significant adverse events reported that were directly attributable to the supplement. Common side effects were not reported at an incidence greater than 5% in the main randomized controlled trial. Due to the limited scope of current research, uncommon or rare side effects are not well documented, and no serious adverse events have been reported. While no specific drug interactions have been well-documented, caution is advised when combining Satiereal with serotonergic drugs due to the potential for additive effects on serotonin pathways. Contraindications are not clearly established, but standard precautions apply to pregnant or lactating individuals, and those with pre-existing serotonin-related conditions. Data regarding safety in special populations such as children, the elderly, or individuals with comorbidities are currently lacking.
Dosage
The minimum effective dose of Satiereal, as established in the primary clinical trial, is 176.5 mg per day. This dosage was administered in an oral capsule form, standardized to saffron stigma extract. Currently, the optimal dosage ranges are limited to this studied dose, as no dose-ranging studies are available to determine efficacy at different levels. The maximum safe dose has not been established beyond the studied amount, and safety data is primarily limited to this specific dosage. In the clinical trial, Satiereal was administered twice daily. There are no specific cofactors or absorption enhancers reported to significantly impact its absorption or efficacy.
FAQs
Is Satiereal safe for long-term use?
Current data on Satiereal's safety is limited to an 8-week period. While short-term use appears safe and well-tolerated, long-term safety and efficacy beyond this duration have not been established.
Can Satiereal be combined with other weight loss supplements?
There is no direct evidence regarding the safety or efficacy of combining Satiereal with other weight loss supplements. Caution is advised, and consultation with a healthcare professional is recommended.
How quickly can results be expected from Satiereal?
In clinical trials, effects such as reduced snacking frequency and modest weight loss were observed within an 8-week supplementation period. Individual results may vary.
Does Satiereal affect mood?
Satiereal is hypothesized to have mood-enhancing effects, potentially contributing to reduced stress-related eating. However, direct and conclusive evidence specifically demonstrating mood improvement from Satiereal is limited.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/20579522/ – This randomized, double-blind, placebo-controlled study investigated the effects of Satiereal (176.5 mg/day) in 60 mildly overweight women over 8 weeks. It found that Satiereal significantly reduced snacking frequency and led to greater body weight reduction compared to placebo, suggesting its efficacy in appetite control and weight management.
- https://www.semanticscholar.org/paper/Satiereal,-a-Crocus-sativus-L-extract,-reduces-and-Gout-Bourg%C3%A8s/2ca00dbd81bf75119e2656a08ccd31744612076e – This paper, likely the full text or a detailed report of the Gout et al. 2010 study, details the methodology and results of the RCT on Satiereal. It confirms that Satiereal, a Crocus sativus L. extract, effectively reduced snacking and body weight in mildly overweight women, supporting its role in satiety and weight management.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5747362/ – This systematic review of saffron RCTs (not specific to Satiereal) explores the broader benefits of saffron. It indicates potential benefits of saffron on mood and appetite regulation, providing a general context for Satiereal's proposed mechanisms, though direct evidence for Satiereal itself remains limited within this review.
- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1071514/full – This systematic review and meta-analysis focuses on saffron supplementation's effects on oxidative stress markers. While not directly addressing appetite or weight loss, it highlights saffron's antioxidant potential, which could be an indirect benefit of Satiereal, though its primary mechanism for weight management is distinct.