S7 No Boosting Herbal Extract Blend
Also known as: S7 Plant-Based Blend, S7 Nitric Oxide Booster, S7 No Boosting Herbal Extract Blend, S7
Overview
S7 is a patented, proprietary blend of seven plant-derived ingredients designed to enhance endogenous nitric oxide (NO) production, improve blood flow, combat oxidative stress, and support exercise performance and recovery. The blend consists of green coffee bean extract, green tea leaf extract, turmeric rhizome extract, tart cherry fruit, blueberry fruit, broccoli head, and kale leaf. It functions as a non-nitrate, stimulant-free supplement, effective at a low dose of 50 mg. S7 acts both as a nitric oxide enhancer and an antioxidant, leveraging the synergistic effects of its botanical components. While early research, including randomized, double-blind, placebo-controlled clinical trials, shows promising results, the evidence base is still developing, with some studies having small sample sizes and limited independent replication.
Benefits
S7 has demonstrated several evidence-based benefits, primarily centered around nitric oxide enhancement and antioxidant activity. A key benefit is its ability to acutely increase circulating nitric oxide levels by approximately 230% after a single 50 mg dose, as shown in a double-blind, placebo-controlled study. Furthermore, daily supplementation has been observed to sustain a 53% increase in nitric oxide levels over 90 days. These significant increases in NO are crucial for vascular health and blood flow. Secondary benefits include a modest but biologically relevant reduction in mitochondrial and cellular reactive oxygen species (ROS) generation by up to 18%, and extracellular oxidant species by up to 44.5%, indicating its antioxidant properties. It also shows potential in inhibiting tumor necrosis factor alpha (TNF-α) induced inflammatory resistance by 13-18%. These benefits are primarily observed in healthy adults, with potential applications for athletes seeking improved endurance and recovery, although direct performance outcomes require further investigation. The nitric oxide increases are statistically significant, while antioxidant effects are modest but contribute to overall cellular health.
How it works
S7 primarily enhances endogenous nitric oxide (NO) production through the synergistic action of its plant polyphenols and bioactive compounds. These compounds stimulate nitric oxide synthase (NOS) activity, an enzyme responsible for NO synthesis, and simultaneously reduce the oxidative degradation of existing NO, thereby increasing its bioavailability. The blend's antioxidant properties, targeting mitochondrial ROS pathways and the NADPH oxidase system, further contribute to NO preservation by mitigating oxidative stress that can inactivate NO. By increasing NO bioavailability, S7 improves vascular endothelial function, leading to vasodilation and enhanced blood flow. Additionally, its components interact with inflammatory pathways, such as TNF-α signaling, to reduce inflammation. The effectiveness at a low 50 mg dose suggests good bioavailability of its active phytochemicals.
Side effects
S7 is generally regarded as safe, with no significant adverse effects reported in clinical studies to date. Based on available research, there are no common (>5%), uncommon (1-5%), or rare (<1%) side effects documented. The constituent plant extracts are widely consumed and considered safe. While no specific drug interactions have been documented, theoretical caution is advised for individuals taking medications that affect blood pressure or nitric oxide pathways, due to the potential for additive effects. There are no explicit contraindications, but standard precautions for botanical supplements apply. Safety in specific populations such as pregnant or lactating women, children, or individuals with chronic diseases has not been established, and therefore, use in these groups should be approached with caution and under medical supervision. Overall, the safety profile appears favorable based on current, albeit limited, clinical data.
Dosage
The minimum effective dose of S7, as demonstrated in clinical trials, is 50 mg daily. This dosage has been shown to elicit both acute and sustained increases in nitric oxide levels. There is no established optimal dosage range beyond this 50 mg, as clinical studies have exclusively utilized this amount, and no data exists on the efficacy or safety of higher doses. Consequently, the maximum safe dose has not been determined. For acute nitric oxide boosting, effects can be observed shortly after dosing. For sustained benefits, daily supplementation is recommended. S7 is typically delivered as a standardized proprietary blend in capsule or powder form. While not specifically studied, co-ingestion with food might enhance the absorption of its polyphenol content, though this is not a strict requirement. No specific cofactors are required for its efficacy.
FAQs
How quickly does S7 work?
S7 can acutely increase nitric oxide levels within hours after a single 50 mg dose, providing a rapid boost in NO bioavailability.
Can S7 replace nitrate supplements?
S7 offers a non-nitrate, plant-based alternative for boosting nitric oxide, providing a different mechanism of action compared to synthetic nitrates or beet-derived supplements, without stimulants.
Will S7 improve exercise performance?
While S7 significantly increases nitric oxide, which is beneficial for blood flow and muscle function, direct evidence on its impact on exercise performance outcomes is still limited and requires further research.
Is S7 stimulant-free?
Yes, S7 is formulated to be stimulant-free, making it suitable for individuals sensitive to stimulants or those who prefer to avoid them.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/29110555/ – This pilot double-blind, placebo-controlled crossover study with 8 healthy adults investigated the effects of S7 on redox signaling. It found that a single dose of S7 significantly inhibited mitochondrial and cellular reactive oxygen species (ROS) by up to 17.7% and extracellular oxidants by up to 44.5%. The study also reported an increase in bioavailable nitric oxide by 1.7 to 2.3 times and a reduction in inflammatory resistance. Despite the small sample size, the results suggest promising antioxidant and NO-boosting properties.
- https://www.mdriveformen.com/pages/s7 – This source, referencing unpublished detailed data, highlights a randomized, double-blind, placebo-controlled trial on S7's nitric oxide increase. It reports an acute 230% increase in circulating nitric oxide after a 50 mg dose and a sustained 53% increase after 90 days of daily supplementation. The study indicates statistically significant results compared to placebo, supporting S7's efficacy in boosting NO levels.
- https://www.futureceuticals.com/s7 – This source provides an overview of S7, confirming its composition as a blend of seven plant-derived ingredients. It reiterates S7's primary function as an enhancer of endogenous nitric oxide production and its role in supporting exercise performance and recovery. The information aligns with the reported benefits of increased NO and antioxidant activity, emphasizing its patented nature and low effective dose.
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