Get Your Personalized Supplement StackSupplement Stack Quiz

Rutaecarpine

Also known as: Rutaecarpine, Evodia rutaecarpa extract

Overview

Rutaecarpine is a quinazoline alkaloid derived from the plant *Evodia rutaecarpa*, a staple in traditional Chinese medicine. It has garnered attention for its potential therapeutic applications, particularly in cancer research, bone health, and gastrointestinal protection. In vitro and animal studies suggest that rutaecarpine exhibits cytotoxic effects on cancer cells, promotes osteoblastic differentiation, and offers gastroprotective benefits through the upregulation of the SHH signaling pathway. However, it's crucial to note that research on rutaecarpine is still in its preliminary stages, with a significant gap in human clinical trials. The available evidence primarily stems from cell culture and animal models, limiting the ability to draw definitive conclusions about its efficacy and safety in humans. Further research is needed to validate these findings and establish appropriate dosing guidelines.

Benefits

Rutaecarpine has demonstrated several potential benefits in preclinical studies. In vitro studies have shown that it induces apoptosis in breast cancer cells, specifically MCF-7 and MDA-MB-231 cell lines. Additionally, research indicates that rutaecarpine enhances osteoblastic differentiation and bone formation in human bone marrow-derived mesenchymal stem cells, suggesting potential benefits for bone health. Animal studies suggest gastroprotective effects by upregulating the SHH signaling pathway and reducing apoptosis in gastric cells. However, it is important to note that these benefits are primarily observed in cell culture and animal studies, and clinical significance in humans is not yet established due to the lack of human trials. Therefore, the evidence is considered preliminary and requires further validation.

How it works

Rutaecarpine's mechanism of action involves several biological pathways. It induces apoptosis in cancer cells, potentially through interactions with cell death pathways. In bone health, it enhances osteoblastic differentiation, promoting bone formation. For gastroprotection, rutaecarpine upregulates the SHH signaling pathway, which is crucial for maintaining gastric mucosal integrity and reducing apoptosis in gastric cells. While specific molecular targets are not fully defined, rutaecarpine appears to interact with cellular pathways related to cell death, differentiation, and signaling pathways involved in bone and gastric health. Information on the absorption and bioavailability of rutaecarpine in humans is currently limited.

Side effects

The safety profile of rutaecarpine is not well-established due to the limited number of human clinical trials. As a result, common, uncommon, and rare side effects have not been reported in available literature. Potential drug interactions and contraindications are also not well-studied. Given the lack of comprehensive safety data, caution is advised when considering rutaecarpine supplementation. Special populations, such as pregnant or breastfeeding women, children, and individuals with pre-existing medical conditions, should avoid rutaecarpine due to insufficient safety data. Further research is needed to fully understand the safety profile of rutaecarpine and identify any potential adverse effects or interactions.

Dosage

Due to the limited research on rutaecarpine in humans, specific dosing guidelines have not been established. Minimum effective dose, optimal dosage ranges, and maximum safe dose are currently unknown. Timing considerations, form-specific recommendations, absorption factors, and required cofactors are also not well-defined. Without sufficient human data, it is not possible to provide reliable dosage recommendations for rutaecarpine. Further research is needed to determine appropriate and safe dosing strategies.

FAQs

What is rutaecarpine used for?

Rutaecarpine is being studied for potential therapeutic effects on cancer, bone health, and gastrointestinal issues, based on in vitro and animal studies. However, human clinical trials are lacking.

Is rutaecarpine safe?

The safety of rutaecarpine is not well-established due to a lack of human clinical trials. Caution is advised, and special populations should avoid it until more data are available.

How should rutaecarpine be taken?

There are no established dosing guidelines for rutaecarpine in humans. More research is needed to determine appropriate and safe dosing strategies.

What are the expected results from taking rutaecarpine?

Potential benefits are based on in vitro and animal studies, including cytotoxic effects on cancer cells and gastroprotective properties. Clinical significance in humans is not yet established.

Research Sources

https://journals.lww.com/cancerjournal/fulltext/2021/17040/comparison_of_the_effects_of_rutaecarpine_on.26.aspx – This study compared the effects of rutaecarpine on MCF-7 and MDA-MB-231 breast cancer cells, finding significant cytotoxic and apoptotic effects in vitro. The research suggests potential anti-cancer properties of rutaecarpine, but it is important to note that the study was conducted in vitro and did not involve human subjects.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11024792/ – This study demonstrated that rutaecarpine enhances osteoblastic differentiation and bone formation in human bone marrow-derived mesenchymal stem cells. The findings suggest potential benefits for bone health, but the study lacks in vivo human data, limiting the ability to draw definitive conclusions about its efficacy in humans.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10489734/ – This research showed that rutaecarpine has gastroprotective effects by upregulating the SHH signaling pathway in a model of chronic atrophic gastritis. The study used animal models and in vitro techniques, indicating potential benefits for gastrointestinal health, but further research is needed to confirm these effects in humans.
https://www.jomh.org/articles/10.22514/jomh.2024.183 – This article discusses recent advancements in understanding rutaecarpine's mechanisms and therapeutic potential. It highlights the need for further research to translate preclinical findings into clinical applications, emphasizing the importance of human studies to validate its efficacy and safety.
https://www.medrxiv.org/content/10.1101/2024.05.07.24306986v1.full-text – This preprint explores the potential of rutaecarpine as an anti-inflammatory agent. The study suggests that rutaecarpine may modulate inflammatory pathways, but further peer-reviewed research is necessary to confirm these findings and determine its clinical relevance.