Get Your Personalized Supplement StackSupplement Stack Quiz

resVida Resveratrol

Also known as: Resveratrol, ResVida, 3,5,4'-trihydroxy-trans-stilbene, Trans-resveratrol

Overview

Trans-resveratrol is a natural polyphenolic stilbene compound found in various plants, including grapes, red wine, berries, and peanuts. It is widely investigated as a dietary supplement due to its potential antioxidant, anti-inflammatory, and anti-aging properties. ResVida is a specific branded, high-purity form of trans-resveratrol that has been used in several clinical studies. While extensive preclinical data suggest a broad range of benefits, human clinical trial evidence is growing but remains mixed and often shows modest effects. It is primarily studied for its potential role in cardiovascular health, metabolic syndrome, cognitive function, and its ability to activate SIRT1, mimicking some effects of calorie restriction. Its primary uses are in the areas of cardiovascular health, metabolic syndrome, and as an antioxidant.

Benefits

Resveratrol, particularly the high-purity trans-resveratrol form like ResVida, has shown several evidence-based benefits, though effect sizes are often modest. In obese subjects, 150 mg/day of ResVida for 30 days led to metabolic improvements, including reduced plasma triglycerides, blood pressure, and hepatic lipid content, suggesting a calorie restriction-mimicking effect (moderate evidence from RCTs). Cardiovascular benefits, such as anti-inflammatory, antiatherogenic, and antihypertensive effects, have been reported in multiple studies, but their clinical significance varies (moderate evidence from reviews). For diabetic patients, doses above 300 mg/day may lead to blood pressure reductions (moderate evidence). Preliminary evidence suggests potential for slowing cognitive decline in Alzheimer's patients, though not statistically significant in small RCTs (low evidence). In cancer research, pilot studies have shown improvements in apoptosis markers in colorectal cancer and a potential reduction in PSA doubling time in prostate cancer patients with specific genetic polymorphisms, but no overall effect on PSA or hormone levels in benign prostate hyperplasia (low evidence). Benefits are typically observed in short-term supplementation, with long-term effects requiring further study.

How it works

Resveratrol exerts its effects primarily through the activation of SIRT1, a protein involved in cellular metabolism and aging. It also modulates mitochondrial function, enhances antioxidant defenses, and exhibits anti-inflammatory properties. At a molecular level, it interacts with pathways involving PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) and nitric oxide, influencing energy metabolism and vascular health. These actions contribute to its observed effects on the cardiovascular, metabolic, and neurological systems. Oral bioavailability is generally low due to rapid metabolism and enterohepatic recirculation, but its metabolites are detectable in plasma and urine within hours of ingestion.

Side effects

ResVida, a high-purity trans-resveratrol, is generally well tolerated and exhibits low oral toxicity. The most commonly reported side effect is mild gastrointestinal discomfort, which is rare. Clinical trials, even with doses up to several grams per day for several months, have not reported significant adverse events. However, due to its potential effects on cytochrome P450 enzymes, there is a theoretical risk of drug interactions, although these are not well characterized. Caution is advised when combining resveratrol with other medications. Specific contraindications are not well-defined due to limited data, but caution is recommended for pregnant or breastfeeding individuals and children, as studies in these populations are lacking. Overall, the safety profile appears favorable, but long-term safety data, especially at very high doses, are still emerging.

Dosage

Clinical effects of trans-resveratrol have been observed at varying dosages. Metabolic improvements, such as reduced triglycerides and blood pressure, have been noted with doses as low as 150 mg/day (using ResVida). For blood pressure reductions in diabetic patients, doses exceeding 300 mg/day appear more effective. There is no definitively established optimal dosage, with many studies utilizing ranges from 150 mg/day to 1000 mg/day. Studies have shown good safety with doses up to 4000 mg/day, but without demonstrating additional efficacy beyond lower doses. Once-daily dosing is common, and the timing of intake can influence bioavailability, which is also affected by the food matrix. Trans-resveratrol, particularly in high-purity forms like ResVida, is preferred for its stability and purity. Due to its low oral bioavailability and rapid metabolism, absorption factors like the food matrix and enterohepatic recirculation play a role in plasma levels.

FAQs

Is ResVida safe?

Yes, high-purity trans-resveratrol (ResVida) is considered safe and well-tolerated in doses up to several grams daily for several months, with rare reports of mild gastrointestinal discomfort.

How soon can I expect to see effects?

Metabolic effects, such as improvements in triglycerides and blood pressure, have been observed after 30 days of consistent supplementation. Longer-term benefits require more research.

Does it improve heart health?

Evidence suggests modest cardiovascular benefits, including anti-inflammatory and blood pressure-lowering effects. However, the overall clinical impact can vary among individuals.

Is it effective for cognitive decline?

Small studies have shown trends towards improved cognitive function, but statistically significant improvements have not been consistently demonstrated. More research is needed.

Does it help with cancer?

Current evidence for cancer is limited and preliminary. While some pilot studies show promising markers, there is no conclusive evidence of overall benefit on cancer progression or markers like PSA.

Research Sources

https://www.nmi.health/resveratrol-a-review-of-clinical-use-and-efficacy/ – This review provides a comprehensive overview of resveratrol's clinical use and efficacy, summarizing findings from various RCTs and meta-analyses. It highlights mixed results, noting no overall PSA benefit in prostate cancer, blood pressure reduction in diabetic subgroups, and modest cognitive effects, while also discussing heterogeneity and small effect sizes across studies.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3880862/ – This randomized controlled trial investigated the effects of ResVida (150 mg/day) in 11 obese healthy males over 30 days. Key findings included reductions in triglycerides, blood pressure, and hepatic lipids, along with improved mitochondrial function. The study, despite its small sample size and short duration, was well-controlled and provided moderate-quality evidence for metabolic benefits.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6317057/ – This systematic review synthesized findings from multiple human trials over a 10-year period, concluding that resveratrol is generally safe, though its bioavailability is variable. It covers effects on oxidative stress, inflammation, type 2 diabetes, cardiovascular diseases, and neurological conditions, acknowledging variable study designs and doses while providing high-quality, broad coverage of the research.
https://www.liebertpub.com/doi/10.1089/jmf.2016.3856 – This source likely discusses aspects of resveratrol's effects, potentially focusing on its impact on specific health markers or conditions. Without direct access to the content, it's inferred to contribute to the understanding of resveratrol's clinical significance, possibly in cardiovascular health or metabolic syndrome, given the context of other provided sources.
https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1749-6632.2010.05855.x – This source, likely a review or research article, contributes to the understanding of resveratrol's broader biological activities and potential health benefits. It is expected to cover its mechanisms of action and therapeutic implications, possibly in the context of aging or chronic diseases, aligning with the general research themes of resveratrol.