Red Wine Grape; Powder
Also known as: red wine grape, red wine grape powder, red wine grape extract, grape polyphenols, Vitis vinifera
Overview
Red wine grape powder is a dietary supplement made from the dried and powdered form of red grapes, specifically sourced from grapes used in wine production, which are rich in polyphenols such as resveratrol, anthocyanins, and flavanols. This supplement is characterized by its high polyphenol content, contributing to its perceived health benefits, including antioxidant, anti-inflammatory, and cardiovascular protective effects. Although moderate research has been conducted, the quality of evidence varies, with some studies indicating significant health improvements while others yield less definitive outcomes. Overall, red wine grape powder is used in health applications aimed at enhancing heart health, reducing inflammation, and promoting overall well-being.
Benefits
Evidence suggests that polyphenols in red wine grape powder can help lower systolic blood pressure, evidenced by a meta-analysis that reported a reduction of approximately -2.6 mmHg. This effect may provide significant benefits for individuals at risk of cardiovascular disease. Additionally, the antioxidant and anti-inflammatory properties of grape polyphenols may benefit patients with chronic kidney disease. Some studies indicate that they can also reduce C-reactive protein levels, a marker of inflammation, although results are inconsistent. Overall, the supplement shows potential particularly among at-risk populations, with blood pressure-lowering effects typically observed within weeks to months.
How it works
Red wine grape polyphenols exert their effects primarily through antioxidant and anti-inflammatory pathways. They improve vascular function and help lower blood pressure through modulation of blood vessel relaxation and inflammation reduction. Key molecular targets include enzymes and pathways associated with oxidative stress and inflammation, such as the NF-κB pathway. The bioavailability of these compounds can vary but is generally enhanced when consumed in conjunction with dietary fats.
Side effects
Red wine grape powder is generally considered safe in moderate amounts; however, it is associated with several potential side effects. Common side effects, occurring in more than 5% of users, include gastrointestinal upset such as bloating and diarrhea. Allergic reactions or interactions with specific medications (like blood thinners or diabetes medications) may occur, though these side effects are reported in less than 5% of users. Rarely (in less than 1% of users), severe allergic reactions may happen. Due to these potential interactions, individuals with severe grape allergies or those on specific medications should seek medical advice before use. Pregnant or breastfeeding women are also advised to consult a healthcare provider.
Dosage
While the minimum effective dose for red wine grape powder is not clearly defined, studies have utilized doses of around 500 mg of polyphenols daily. The optimal dosage range generally falls between 500 mg and 1 g of polyphenols per day. Although a maximum safe dose is not established, higher doses may increase the risk of adverse effects. Taking the supplement with meals can help mitigate potential gastrointestinal discomfort, and the dosage form can be in powders or capsules. It is noted that the presence of dietary fats can enhance the absorption of polyphenols.
FAQs
Is red wine grape powder safe?
Generally, yes, it is safe when taken in moderate amounts, but consult a healthcare provider if you are on medications or have allergies.
How should I take red wine grape powder?
It can be taken with meals to minimize gastrointestinal upset and enhance absorption.
When can I expect to see benefits?
Benefits may take several weeks to manifest, depending on individual health conditions and dosage.
Can red wine grape powder be used instead of medication?
No, it should not replace prescribed medical treatments. Consult a healthcare provider for specific health conditions.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/32303823/ – This systematic review and meta-analysis examined the effects of red wine polyphenols on blood pressure, demonstrating a modest reduction in systolic blood pressure by approximately -2.6 mmHg among human studies, with noted variability in outcomes.
- https://pubmed.ncbi.nlm.nih.gov/25517279/ – A randomized controlled trial involving 32 non-diabetic hemodialysis patients highlighted that grape powder supplementation increased antioxidant activity via glutathione peroxidase without affecting inflammation markers like CRP over a study duration of five weeks.
- https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-grape-products-containing-polyphenols-on-creactive-protein-levels-a-systematic-review-and-metaanalysis-of-randomised-controlled-trials/59C5DC9AEC42490227F9CE5B8C35D87B – This systematic review highlighted the inconsistent effects of grape products on C-reactive protein levels, emphasizing the heterogeneity among studies and urging caution in interpretation of the results.
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