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Raspberry seed extract

Also known as: Raspberry seed extract, RSE, Raspberry seed oil, RSO, Rubus idaeus L. seed extract

Overview

Raspberry seed extract (RSE) is derived from the seeds of the red raspberry plant, Rubus idaeus L. It is a plant-derived dietary supplement rich in bioactive compounds, including polyphenols, flavonoids, tocopherols, phytosterols, carotenoids, and notably, polyunsaturated fatty acids (PUFAs), especially α-linolenic acid (an omega-3 fatty acid). While often marketed for its antioxidant, anti-inflammatory, and potential cardiovascular and skin health benefits, direct high-quality clinical evidence specifically for isolated RSE is limited. Much of the existing research focuses on whole raspberry fruit consumption or the chemical composition of the seed oil. RSE is used in both oral dietary supplements and topical formulations, with its oil fraction particularly valued for its essential fatty acid content.

Benefits

Despite its rich composition of beneficial compounds, current high-quality evidence from meta-analyses of raspberry consumption (not isolated seed extract) indicates no significant effect on lipid profiles (total cholesterol, LDL, HDL, triglycerides) or blood pressure compared to controls. While the seed oil is rich in α-linolenic acid (29.9–41.3 g/100 g), which is known to have cardiovascular benefits from other research, direct randomized controlled trial (RCT) evidence for RSE supplementation specifically is lacking. Secondary benefits, such as antioxidant and anti-inflammatory potential, are inferred from the presence of bioactive compounds, but their clinical translation and significance in humans remain largely unestablished. No conclusive data from RCTs support population-specific benefits for RSE.

How it works

Raspberry seed extract's proposed mechanisms of action are primarily inferred from its rich phytochemical profile. Its antioxidant activity is attributed to polyphenols and tocopherols, which scavenge free radicals and reduce oxidative stress. Anti-inflammatory effects are thought to occur through the modulation of inflammatory cytokines and pathways. The high content of α-linolenic acid (an omega-3 fatty acid) in the seed oil fraction suggests potential for modulating lipid metabolism and supporting cardiovascular health, similar to other omega-3 sources. These compounds may interact with various body systems, potentially supporting cardiovascular function through lipid regulation and blood pressure modulation, and aiding skin barrier function via essential fatty acids. However, specific molecular targets and direct human physiological interactions for isolated RSE are not well-defined in clinical studies.

Side effects

Raspberry seed extract is generally regarded as safe when consumed as food or a dietary supplement, with no major adverse effects reported in clinical trials involving raspberry consumption. Common, uncommon, or rare side effects have not been documented in research. There are no established drug interactions, although caution is advised with anticoagulants due to the fatty acid content, which theoretically could have mild antiplatelet effects. No specific contraindications have been identified. For special populations, such as pregnant or breastfeeding women, data are limited, and consultation with a healthcare provider is recommended before use. Overall, the safety profile appears favorable, but comprehensive safety data specifically for isolated, high-dose RSE supplementation are scarce.

Dosage

The minimum effective dose for isolated raspberry seed extract has not been established, and there is no consensus on optimal dosage ranges. Studies on whole raspberry fruit or extracts have used doses ranging from 100 mg to several grams, but these do not provide specific guidance for isolated seed extract. A maximum safe dose has also not been determined, though no toxicity has been reported at typical dietary levels. There is no specific data regarding optimal timing or frequency of RSE supplementation. For the seed oil, it can be used both topically and orally. Absorption of fatty acids may be enhanced when consumed with dietary fat, while polyphenol absorption can be variable. No specific cofactors are known to be required for its efficacy.

FAQs

Does raspberry seed extract lower cholesterol or blood pressure?

Current meta-analyses of raspberry consumption (not isolated seed extract) show no significant effect on lipid profiles or blood pressure. Direct evidence for RSE is lacking.

Is raspberry seed oil beneficial for skin?

Anecdotal evidence and in vitro studies suggest moisturizing and antioxidant properties for skin, but robust clinical data specifically for RSE's topical benefits are limited.

Are there safety concerns with raspberry seed extract?

Raspberry seed extract is generally considered safe, with no major adverse effects reported in clinical studies of raspberry consumption. No specific drug interactions are documented, but caution is advised with anticoagulants.

How long does it take to see effects from raspberry seed extract?

There are no clinical data available to specify the time course for the onset of any potential effects from raspberry seed extract supplementation.

Is raspberry seed extract the same as raspberry ketone?

No, raspberry seed extract is distinct from raspberry ketone. Raspberry ketone is a specific phenolic compound, while RSE is a complex extract containing various bioactive compounds.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC11016397/ – This systematic review and meta-analysis of 11 RCTs found that raspberry consumption did not significantly affect lipid profiles (total cholesterol, LDL, HDL, triglycerides) or blood pressure in adults. The study highlights the lack of significant clinical benefits for these cardiovascular markers despite the presence of beneficial compounds in raspberries.
https://onlinelibrary.wiley.com/doi/abs/10.1002/fsn3.3940 – This source likely refers to the same meta-analysis as the previous one, reinforcing the finding that raspberry consumption does not significantly impact cardiovascular risk factors like lipid profiles or blood pressure. It underscores the need for more targeted research on specific raspberry components.
https://pubs.acs.org/doi/10.1021/acsfoodscitech.2c00120 – This analytical study focused on the chemical composition of black raspberry seed oil, revealing its richness in α-linolenic acid (29.9–41.3 g/100 g) and other bioactive compounds. While it provides high-quality chemical profiling, it does not offer clinical outcomes or data on human efficacy.
https://consensus.app/search/does-raspberry-seed-oil-supplementation-have-simil/16D1F0e5QzKXu3u7a79o9w/ – This source likely summarizes the current scientific consensus regarding raspberry seed oil supplementation, indicating that direct clinical evidence for its efficacy in humans is limited. It suggests that while the oil contains beneficial compounds, robust human trials are needed to confirm health benefits.