Ranunculus Ternatus
Also known as: Mao zhua cao, Buttercup, Ranunculus ternatus
Overview
*Ranunculus ternatus* is a traditional herbal supplement utilized in Chinese medicine, noted for its anti-inflammatory and anticancer properties. It is primarily employed in the treatment of conditions such as cancer, hepatitis, and liver fibrosis. The plant is characterized by the presence of flavonoids, endolipids, and sterols, which contribute to its pharmacological effects. Although it shows promise, research evidence is still evolving, with a need for more clinical trials and systematic reviews to comprehensively validate its therapeutic potentials. Currently, most studies delve into its potential therapeutic effects rather than robust clinical outcomes, highlighting a moderate level of research maturity in this field.
Benefits
Primary benefits include potential anticancer effects, particularly against breast cancer, identified through network pharmacology and molecular docking studies, though these results require clinical validation. Secondary benefits consist of anti-inflammatory and hepatoprotective effects, suggesting its role in managing liver fibrosis. While some evidence exists for its efficacy in cancer and liver diseases, the specific populations that benefit most are not well-defined, and overall quantitative data on effect sizes is limited due to the lack of rigorous clinical trials. The time course of these benefits remains poorly documented, necessitating further research to clarify these aspects.
How it works
The mechanism of action for *Ranunculus ternatus* involves various cell metabolic pathways and steroidogenesis, notably influencing signaling pathways such as ESR1 and CYP19A1. It engages with couple body systems, including endocrine and immune systems, targeting several molecular sites such as ESR1, HSD17B1, and CYP1B1 among others. However, detailed information on absorption and bioavailability is currently not well-defined.
Side effects
While generally deemed safe in traditional contexts, comprehensive safety profiles for *Ranunculus ternatus* remain sparse and variable. Common side effects are not documented, and both uncommon and rare adverse effects have not been identified. Potential drug interactions have not been thoroughly studied, and specific contraindications are absent, making it difficult to establish safety guidelines. Special caution is advised for pregnant or breastfeeding women due to the lack of safety data in these populations. The need for individualized assessment on risks versus benefits is critical given the existing evidence gaps.
Dosage
Currently, there are no established guidelines for effective, optimal, or maximum dosages for *Ranunculus ternatus*. Traditional usage typically encompasses herbal preparations without specified timing or form recommendations. Factors influencing absorption remain unknown, and required cofactors have not been identified, underscoring the importance of further research. Given the lack of detailed dosaging information, it is prudent for users to seek counsel from healthcare professionals before use.
FAQs
What should I consider before using Ranunculus ternatus?
Consult healthcare providers due to limited safety and efficacy data.
Is it safe for pregnant or breastfeeding women?
Caution is advised as safety data for these groups are lacking.
What results can I expect?
Results may vary significantly depending on the specific condition.
Can it interact with other medications?
Potential interactions are not well-studied; caution is recommended.
Is it a proven treatment for any condition?
No, clinical validation is needed for its therapeutic claims.
Research Sources
- https://www.heraldopenaccess.us/openaccess/uncovering-the-mechanisms-of-ranunculus-ternatus-against-breast-cancer-based-on-network-pharmacology-and-molecular-docking – This study employs network pharmacology and molecular docking to explore the mechanisms of *Ranunculus ternatus* against breast cancer. It identifies potential signaling pathways but highlights a lack of clinical validation.
- https://www.mdpi.com/1420-3049/18/10/11859 – This article details the therapeutic properties of *Ranunculus ternatus*, focusing on its anti-inflammatory and hepatoprotective effects, particularly for liver fibrosis, indicating the need for further clinical investigations.
- https://www.aging-us.com/article/205629/text – This in vitro study found compounds from *Ranunculus ternatus* exhibit antimycobacterial activity against *Mycobacterium tuberculosis*, though findings need clinical trial confirmation for human health implications.
- https://www.heraldopenaccess.us/article_pdf/9/uncovering-the-mechanisms-of-ranunculus-ternatus-against-breast-cancer-based-on-network-pharmacology-and-molecular-docking.pdf – The paper reaffirms findings related to the anticancer effects of *Ranunculus ternatus*, emphasizing the pathways involved and calling for rigorous clinical trials to substantiate these effects.
- https://www.researchgate.net/publication/361394411_Therapeutic_Potential_of_Ranunculus_Species_Ranunculaceae_A_Literature_Review_on_Traditional_Medicinal_Herbs – This literature review discusses traditional uses of various *Ranunculus* species, including * Ranunculus ternatus*, outlining their therapeutic potentials and the need for more systematic evaluations.
