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Chinese Quince Dried Fruit Liquid Extract

Also known as: Cydonia oblonga Miller, Chinese quince, quince, Cydonia oblonga

Overview

Chinese quince dried fruit liquid extract is derived from the fruit of *Cydonia oblonga*, a plant renowned for its rich composition of polyphenols, flavonoids, and dietary fiber. This botanical extract is traditionally utilized for its antioxidant, anti-inflammatory, and anti-diabetic properties. The extraction process typically involves soaking and homogenizing dried quince fruit, followed by centrifugation to separate the liquid extract from the pulp. Its primary applications in the supplement domain include providing antioxidant support, modulating inflammatory responses, aiding metabolic health, and potentially offering antiviral benefits. While research on Chinese quince extract is still in its early stages, several animal and in vitro studies have demonstrated its bioactivity. However, high-quality human clinical trials are currently limited, and systematic reviews specifically on the dried fruit liquid extract are not yet available. Despite this, related phytochemical and pharmacological studies offer valuable insights into its potential health advantages, positioning it as a promising natural ingredient.

Benefits

The Chinese quince dried fruit liquid extract offers several potential health benefits, primarily attributed to its rich phytochemical profile. It exhibits strong **antioxidant activity** due to high levels of phenolic compounds like quercetin, kaempferol derivatives, chlorogenic acid, and polymeric procyanidins, as measured by Trolox equivalent antioxidant capacity (TEAC). This suggests its potential in combating oxidative stress. The extract also demonstrates **anti-inflammatory effects**, with studies showing its ability to inhibit inflammatory mediators such as TNF-α and interleukins in animal models, indicating its role in reducing inflammation. Furthermore, it shows **anti-diabetic potential**; in animal models of diabetes, oral administration of quince fruit extract significantly reduced fasting blood glucose in a dose-dependent manner, partly attributed to 5-hydroxymethylfurfural (5-HMF). This suggests a role in glucose metabolism regulation. **Antiviral activity** has also been observed, with Chinese quince phenolic extracts showing strong anti-influenza viral activity in vitro, outperforming some standard antioxidants. Lastly, research indicates potential for **improved exercise endurance and intestinal protection**; in a mouse model, quince combined with probiotics enhanced antioxidant enzyme activity, reduced intestinal inflammation, and improved exercise endurance, likely due to its polyphenol content. While these findings are promising, most evidence comes from preclinical studies, and human clinical trials are needed to confirm these benefits.

How it works

The biological effects of Chinese quince dried fruit liquid extract are primarily mediated by its rich content of polyphenols and flavonoids. These compounds act as potent antioxidants, effectively scavenging free radicals and modulating oxidative stress pathways within the body. Its anti-inflammatory properties stem from the downregulation of pro-inflammatory cytokines, such as TNF-α and IL-6, and the upregulation of anti-inflammatory cytokines like IL-10. The anti-diabetic effects may involve the modulation of glucose metabolism and the protection of pancreatic β-cells, with 5-HMF identified as a key bioactive component. Antiviral activity is thought to involve the inhibition of viral hemagglutinin function, which prevents viruses from binding to host cells. While the absorption and bioavailability of polyphenols from dried fruit extracts can vary, the liquid extract form may enhance their uptake compared to raw fruit, contributing to its systemic effects.

Side effects

Currently, no significant adverse effects have been reported in animal studies at the tested doses of Chinese quince dried fruit liquid extract. While human safety data are limited, quince fruit is generally considered safe when consumed as food. There are no documented drug interactions or contraindications specifically for the dried fruit liquid extract in the available literature. However, caution is advised for individuals with diabetes due to the extract's demonstrated hypoglycemic potential in preclinical studies. Diabetic patients considering its use should do so under medical supervision to monitor blood glucose levels and adjust medication as necessary. As with any supplement, individuals with pre-existing medical conditions or those taking other medications should consult a healthcare professional before incorporating Chinese quince dried fruit liquid extract into their regimen. Due to the limited human research, the full spectrum of potential side effects, especially with long-term use or at higher doses, remains largely unknown.

Dosage

There are no established human dosing guidelines for Chinese quince dried fruit liquid extract due to the current lack of clinical trials. Preclinical animal studies have utilized doses ranging from 80 to 240 mg/kg body weight administered orally for anti-diabetic effects. However, these dosages cannot be directly extrapolated to humans. The concentration of active compounds can vary significantly depending on the extraction methods used, which further complicates dose standardization. When considering supplementation, it is important to note that the timing and co-administration with other substances, such as probiotics, may enhance certain benefits, particularly for exercise endurance and intestinal health, as observed in animal models. Without human clinical data, any use should be approached cautiously, potentially starting with a low dose and monitoring for effects. Consumers should also be aware that product formulations can differ, and it is advisable to follow manufacturer guidelines or consult with a healthcare professional for personalized advice.

FAQs

Is Chinese quince dried fruit liquid extract safe?

Animal studies suggest safety at tested doses, and quince fruit is generally safe as food. However, human data are limited, so caution is advised, especially for specific health conditions.

Does it help with blood sugar?

Preclinical evidence from animal models supports glucose-lowering effects, indicating potential for blood sugar management. However, human clinical trials are needed to confirm this benefit.

Can it improve exercise performance?

In animal models, when combined with probiotics, it may enhance endurance and reduce oxidative stress, suggesting a potential benefit for exercise performance.

Is it antiviral?

In vitro data show anti-influenza activity, but its clinical relevance and efficacy in humans as an antiviral agent are currently unproven and require further research.

Research Sources

https://www.walshmedicalmedia.com/open-access/nutritional-composition-phytochemistry-and-medicinal-use-of-quince-cydonia-oblonga-miller-with-emphasis-on-its-processed.pdf – This review article summarizes the nutritional composition, phytochemistry, and medicinal uses of quince (*Cydonia oblonga Miller*), with a focus on its processed forms. It highlights the fruit's rich content of polyphenols, flavonoids, and dietary fiber, which contribute to its traditional uses and emerging health benefits, including antioxidant and anti-inflammatory properties. The paper provides a comprehensive overview of the bioactive compounds and their potential therapeutic applications.
https://ouci.dntb.gov.ua/en/works/ldeegkk9/ – This study investigated the anti-diabetic potential of aqueous quince fruit extract in streptozotocin-induced diabetic rats. The research found that oral administration of the extract significantly reduced fasting blood glucose in a dose-dependent manner over 28 days. The findings suggest that 5-hydroxymethylfurfural (5-HMF) is a key active compound contributing to these hypoglycemic effects, supporting quince's traditional use for metabolic health.
https://pubmed.ncbi.nlm.nih.gov/15713000/ – This in vitro study evaluated the antioxidant and anti-influenza viral activity of phenolic extracts from Chinese quince. The results demonstrated strong antioxidant properties and significant anti-influenza viral activity, outperforming some standard antioxidants in hemagglutination inhibition assays. This research suggests that Chinese quince phenolics could be a promising source of natural antiviral and antioxidant agents.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10675360/ – This animal study explored the effects of quince combined with probiotics on exercise endurance and intestinal protection in a mouse swimming model. The findings indicated that the combination enhanced antioxidant enzyme activity, reduced intestinal inflammation, and improved exercise endurance. The study suggests that the polyphenol content of quince, especially when combined with probiotics, contributes to these beneficial effects on gut health and physical performance.