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Pyruvate

Also known as: Sodium Pyruvate

Overview

Pyruvate is a 3-carbon energy intermediate produced in cells from glucose, en route to creating ATP (the main energy currency of working cells). Pyruvate supplementation has been proposed to enhance work output and weight loss by providing more efficient energy that bypasses the ability of the body to store glucose as body fat. Studies in humans with pyruvate supplementation show promise at high dosages when pyruvate replaces dietary carbohydrates. Pyruvate has a lacklustre pharmacodynamic profile, and is not well absorbed. Some studies fail to note increases in blood pyruvate or muscle pyruvate in response to supplementation due to its inability to be absorbed and utilized well. Low doses of pyruvate tend to return null results rather than positive results in healthy persons. Due to its poor absorption, high dose pyruvate is known to cause stomach distress and loose stools in dosages exceeding 15g.

Benefits

Pyruvate functions as an energy intermediate in the body, derived from glucose and fatty acids. It plays a crucial role in the production of ATP, which is essential for energy in cells. When supplemented, pyruvate is thought to enhance energy production and efficiency, particularly during exercise, by providing an alternative energy source that may help in weight loss and improving physical performance.

How it works

The potential benefits of pyruvate supplementation include enhanced energy production, improved exercise performance, and potential weight loss effects. Some studies suggest that it may help in reducing body fat and improving power output during physical activities. However, the evidence is mixed, and results can vary significantly among individuals.

Side effects

Most studies on pyruvate substituted dietary carbohydrates for pyruvate as pyruvate itself does contain calories. The dose used in studies showing most fat loss is in the range of 20-50g daily, or replacing 10-20% of caloric intake (initially from carbohydrates) with supplemental pyruvate. The lowest effective range noted in the aforementioned studies is replacing 6-12g of carbohydrates with pyruvate, but even then the results seen with pyruvate are variable and lacklustre enough to warrant caution in buying this supplement.

Dosage

High doses of pyruvate are known to cause stomach distress and loose stools in dosages exceeding 15g. Other potential side effects may include gastrointestinal discomfort, and caution is advised for individuals with certain health conditions.

FAQs

What is pyruvate?

Pyruvate is a 3-carbon energy intermediate produced in cells from glucose, which plays a crucial role in the production of ATP, the main energy currency of working cells.

How does pyruvate supplementation work?

Pyruvate supplementation is thought to enhance energy production and efficiency, particularly during exercise, by providing an alternative energy source.

What are the benefits of taking pyruvate?

Potential benefits include enhanced energy production, improved exercise performance, and possible weight loss effects.

What is the recommended dosage for pyruvate?

The recommended dosage ranges from 20-50g daily, or replacing 10-20% of caloric intake with supplemental pyruvate.

What side effects can occur with pyruvate supplementation?

Side effects may include stomach distress and loose stools, particularly at high doses.