Pterostilbene
Also known as: trans-3 5-dimethoxy-4-hydroxystilbene
Overview
Pterostilbene is a dimethylated derivative of resveratrol that, for some mechanisms, is more potent. It is also much better absorbed, and is commonly referred to as a 'better resveratrol'. It looks promising, but has significantly less research than its predecessor. Pterostilbene is most often used for Healthy Aging & Longevity.
Benefits
Pterostilbene is a methylated stilbene molecule with structural similarity to resveratrol, the only difference being two methoxy groups on the pterostilbene molecule that replace hydroxy groups on the resveratrol molecule. While most of the actions of the two are comparable, pterostilbene appears to be much more well absorbed following oral ingestion and may be a more potent antioxidant and anticancer molecule.
How it works
Pterostilbene is linked to various health conditions and outcomes, including potential benefits for coronary artery disease, high blood pressure, high cholesterol, metabolic health, and weight loss maintenance. It may help in reducing LDL-cholesterol and has shown a trend towards lower HDL levels in people with high cholesterol levels.
Side effects
Supplementation of pterostilbene for the purpose of aiding glucose and lipid metabolism tends to be around 20-40mg/kg oral ingestion in rats, which is an estimated human dosage range of: 215-430mg for a 150lb person, 290-580mg for a 200lb person, 365-730mg for a 250lb person. Possible anxiolytic properties of pterostilbene are seen at 1-2mg/kg in mice, which is an estimated human dose of: 5.5-11mg for a 150lb person, 7.3-14.5mg for a 200lb person, 9-18mg for a 250lb person. Limited human studies have used either 50mg twice a day or 125mg twice a day.
Dosage
The side effects of pterostilbene may include adverse effects on cholesterol levels, particularly when taken in isolation. The addition of Grape seed extract with lower doses may mitigate some of these adverse effects.
FAQs
What are the other names for Pterostilbene?
Pterostilbene is also known as trans-3 5-dimethoxy-4-hydroxystilbene.
How does Pterostilbene work in the body?
Pterostilbene is a methylated stilbene molecule with structural similarity to resveratrol, and it appears to be much more well absorbed following oral ingestion, potentially acting as a more potent antioxidant and anticancer molecule.
What are the benefits of Pterostilbene?
Pterostilbene may help in reducing LDL-cholesterol and has shown potential benefits for various health conditions including coronary artery disease, high blood pressure, high cholesterol, metabolic health, and weight loss maintenance.
What is the recommended dosage for Pterostilbene?
The estimated human dosage range for aiding glucose and lipid metabolism is 215-430mg for a 150lb person, 290-580mg for a 200lb person, and 365-730mg for a 250lb person. Possible anxiolytic effects are seen at 5.5-11mg for a 150lb person.
Are there any side effects associated with Pterostilbene?
Yes, pterostilbene may have adverse effects on cholesterol levels, especially when taken alone.
Supplements Containing Pterostilbene
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