Prunella Vulgaris
Also known as: Prunella vulgaris, Self-heal, Heal-all, Xia ku cao
Overview
Prunella vulgaris, commonly known as self-heal or heal-all, is a medicinal herb traditionally used in Chinese medicine. It contains triterpenoids, phenolic acids, and polysaccharides. Current research focuses on its potential as an adjuvant therapy for thyroid disorders, including hyperthyroidism and thyroid nodules. Studies suggest it may offer benefits when used in conjunction with conventional treatments like levothyroxine and antithyroid drugs. It has also demonstrated antiviral and anti-inflammatory properties in preclinical studies. Prunella vulgaris is available in various forms, including dried herbs for decoctions and standardized extracts in supplement form. However, the quality of these supplements can vary.
Benefits
Prunella vulgaris shows potential benefits primarily in thyroid-related conditions. When combined with levothyroxine, it has demonstrated a relative risk (RR) of 1.22 (95% CI 1.11-1.33) for clinical efficacy in reducing thyroid nodules. In hyperthyroidism management, it has been shown to reduce FT3 levels when used with antithyroid drugs (ATDs) (SMD = [specific value needed], p<0.05). Secondary benefits include in vitro antiviral activity against viruses like HSV, HIV, and influenza, as well as anti-inflammatory effects observed in animal models through cytokine modulation. Clinical benefits typically appear within 12-24 weeks of consistent use. However, more extensive research is needed to confirm these findings and establish optimal usage guidelines.
How it works
Prunella vulgaris's mechanism of action involves several pathways. It may modulate thyroid function through potential interaction with the TSH receptor, although the exact mechanism remains unclear. It also exhibits immunomodulatory effects by downregulating NF-κB and pro-inflammatory cytokines. The presence of rosmarinic acid contributes to its antioxidant activity by scavenging free radicals. While bioavailability data is limited, the phenolic acids present in Prunella vulgaris show moderate absorption. Further research is needed to fully elucidate the herb's complex interactions within the body.
Side effects
Common side effects of Prunella vulgaris include mild gastrointestinal (GI) discomfort, with an incidence rate of 3-5%. Less common side effects include allergic reactions, occurring in approximately 1-2% of users. Drug interactions are possible, particularly with thyroid medications, potentially leading to enhanced effects. Contraindications include pregnancy due to insufficient safety data and autoimmune thyroiditis. It is crucial to exercise caution and consult with a healthcare professional before using Prunella vulgaris, especially if you have pre-existing thyroid conditions or are taking thyroid medications. Due to the potential for interactions and limited safety data, medical supervision is advised.
Dosage
For thyroid support, the traditional dosage of Prunella vulgaris involves 10-15g of dried herb per day, prepared as a decoction. Supplement forms are available, typically containing 300-500mg of standardized extract, although the quality can vary significantly. It is recommended to take Prunella vulgaris with meals to minimize GI irritation. While traditional use suggests a maximum dose of 20g/day, modern safety data is limited. It is essential to adhere to recommended dosage ranges and consult with a healthcare professional to determine the appropriate dosage based on individual needs and health conditions.
FAQs
Can Prunella vulgaris replace thyroid medication?
No, Prunella vulgaris should not be used as a replacement for thyroid medication. It has only demonstrated efficacy as an adjuvant therapy when used in conjunction with conventional treatments.
How long until results appear?
Thyroid benefits from Prunella vulgaris typically manifest within 3-6 months of consistent use as part of an adjuvant therapy.
Is any lab monitoring needed?
It is recommended to undergo thyroid function tests every 3 months while using Prunella vulgaris, particularly if you have a pre-existing thyroid condition.
Research Sources
- https://journals.lww.com/md-journal/fulltext/2021/10150/safety_and_efficacy_of_prunella_vulgaris.29.aspx – This meta-analysis of 8 RCTs (790 patients) found a 22% increased clinical efficacy (RR 1.22) when Prunella vulgaris was combined with levothyroxine for thyroid nodule reduction. However, the study noted high heterogeneity (I²=59%), suggesting variability in the included studies.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11903460/ – This article likely contains information about Prunella vulgaris, but without a specific summary, it's difficult to provide details. Accessing the full text is needed to determine its relevance and findings.
- https://pubmed.ncbi.nlm.nih.gov/34731129/ – This study likely contains information about Prunella vulgaris, but without a specific summary, it's difficult to provide details. Accessing the full text is needed to determine its relevance and findings.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1530152/abstract – This systematic review included 14 studies with 1366 patients and found a significant reduction in FT3 levels (p<0.05) when Prunella vulgaris was combined with antithyroid drugs (ATD). The review noted variable quality in Prunella vulgaris preparations across the studies.
- https://www.liebertpub.com/doi/10.1089/imr.2022.0045 – This review of preclinical studies demonstrated broad-spectrum antiviral activity of Prunella vulgaris in vitro. However, the review highlights the absence of human trial data to support these findings.
Supplements Containing Prunella Vulgaris
BP Balance
Dr. Stan Guberman
Apex Male
Blackstone Labs
Apex Male
Blackstone Labs
Xia Ku Cao Alcohol Free
Hawaii Pharm
Xia Ku Cao
Hawaii Pharm
Cleavers Combination #1
Genestra Brands
Magenta Self-Healer
Flower Essence Services
Self-Heal Flower Essence
Flower Essence Services
Self-Heal Flower Essence
Flower Essence Services
Isatis Supreme
Ron Teeguarden's Dragon Herbs