ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Protein Blend Proprietary Blend

Also known as: Casein, Whey, Soy, Pea, Rice proteins, Multi-source protein complex, Hybrid protein matrix, Protein Blend Proprietary Blend

Overview

Protein Blend Proprietary Blend refers to a combination of different protein sources, typically including both animal and plant-based proteins. Common components are whey, casein, soy, pea, and rice proteins, although the exact composition is usually undisclosed. These blends are designed to provide a comprehensive amino acid profile and offer varying absorption rates. Whey protein is known for its rapid absorption, while casein provides a sustained release. The research maturity for individual protein components is high, with numerous studies supporting their benefits. However, research specifically on protein blends is less extensive. These blends are often used to support muscle growth, recovery, and overall protein intake, particularly among athletes and individuals with increased protein needs. The efficacy of these blends largely depends on the quality and quantity of the individual protein sources they contain.

Benefits

Protein blends primarily support lean mass gain and strength improvements. Studies show that protein supplementation during resistance training can lead to an average lean mass gain of 0.69kg (95% CI: 0.47-0.91). They also aid in muscle preservation, reducing age-related muscle loss by approximately 0.5-1% annually. Some evidence suggests that protein blends can enhance recovery by reducing muscle soreness. Elderly individuals benefit from a protein intake of 1.2-1.5g/kg/day, while athletes may require 1.6-2.2g/kg/day for optimal muscle hypertrophy. Animal-based blends typically show a 10-15% greater efficacy for hypertrophy compared to plant-based blends.

How it works

Protein blends work by activating the mTOR pathway through their leucine content, typically requiring at least 2-3g of leucine per meal. This activation increases muscle protein synthesis (MPS) rates by 20-50% and attenuates muscle protein breakdown (MPB). The bioavailability of different protein sources varies; whey protein is absorbed rapidly, peaking within 60-90 minutes, while casein offers a sustained release over 4-6 hours. Plant proteins generally have a 10-20% lower bioavailability compared to whey protein. The combination of fast and slow-digesting proteins in blends aims to provide both immediate and sustained amino acid availability to support muscle growth and repair.

Side effects

Common side effects of protein blends include gastrointestinal discomfort such as flatulence and bloating, affecting more than 5% of users. High protein intake can also lead to mild dehydration. Uncommon side effects (1-5%) include allergic reactions, particularly to whey or casein, and constipation, especially with casein-dominant blends. Rare side effects (less than 1%) include kidney stress in individuals with pre-existing renal impairment and hypercalciuria with calcium-fortified blends. Protein blends containing aspartame are contraindicated for individuals with phenylketonuria. Individuals with severe renal impairment should also avoid high protein intake.

Dosage

The minimum effective dosage of protein blends is 0.4g/kg per meal, consumed across four meals per day. The optimal range for athletes is 1.6-2.2g/kg/day. Short-term intake can safely reach up to 3.5g/kg/day. For optimal results, whey-dominant blends should be consumed within 0-2 hours post-exercise to capitalize on the anabolic window. Casein-dominant blends are best taken before sleep to provide a sustained release of amino acids overnight. Individual protein needs vary based on activity level, body weight, and overall health. It is important to maintain adequate hydration with high protein intake.

FAQs

Are blends better than single-source proteins?

There is no clear evidence of superiority. Blends offer a balanced amino acid release, which can be beneficial, but the specific use case determines the best choice.

Plant vs animal blends?

Animal blends typically show a 10-15% greater efficacy for muscle hypertrophy compared to plant-based blends due to their superior amino acid profiles and bioavailability.

Best time to take?

Post-workout (whey-dominant) and pre-sleep (casein-dominant) are optimal times to consume protein blends to maximize muscle protein synthesis and recovery.

Research Sources

  • https://bjsm.bmj.com/content/52/6/376 – This systematic review of 49 RCTs (n=1,863) found that protein supplementation increases lean mass (+1.1kg) and strength. However, the review notes high heterogeneity in protein types, indicating that the specific source of protein can influence the results.
  • https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1455728/full – This meta-analysis of 27 studies (n=1,074 athletes) showed that 1.5g/kg/day of protein improves endurance and strength (ES=0.45). The study acknowledges variable protein quality across studies, which could affect the consistency of the findings.
  • https://www.mdpi.com/2072-6643/16/7/941 – This review of 18 RCTs (n=1,302 middle-aged/older adults) found that protein blends are comparable to whey protein for muscle maintenance. The study notes that the short duration (≤6 months) of the included trials limits the ability to assess long-term effects.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC8978023/ – This article discusses the importance of protein intake for muscle health and overall well-being. It highlights the role of protein in muscle protein synthesis and the benefits of consuming adequate protein, especially for older adults.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC6491698/ – This review explores the effects of protein supplementation on muscle mass, strength, and physical function. It emphasizes the importance of resistance exercise in conjunction with protein intake to maximize muscle growth and function.

Recommended Articles

Top Fertility Supplements for Women in 2025

Top Fertility Supplements for Women in 2025

By 2025, new FDA-approved fertility supplements, emphasizing organic ingredients, have shown significant effectiveness in aiding conception for women in their 30s.

Barcode-Scanner Apps & Supplements: A Reality Check

Barcode-Scanner Apps & Supplements: A Reality Check

Barcode-scanner supplement apps vary in accuracy, especially with proprietary blends, but advancements are improving their reliability.

Legal Pre-Workout Supplements for Athletes

Legal Pre-Workout Supplements for Athletes

Legal pre-workout supplements like those with caffeine, beta-alanine, and creatine can safely enhance athletic performance without failing doping tests.

Top Testosterone Boosters for Cyclists: A Buyer's Guide

Top Testosterone Boosters for Cyclists: A Buyer's Guide

For cyclists, choosing testosterone boosters involves finding scientifically-backed, third-party tested products, with top picks including brands like TestoGen and Prime Male.