Proprietary Mangosteen Tonic Blend
Also known as: Mangosteen, Queen of Fruits, Garcinia mangostana L.
Overview
Mangosteen is a tropical fruit native to Southeast Asia, specifically Thailand and Malaysia. It is renowned for its rich content of bioactive compounds, particularly xanthones, found in the pericarp (rind) of the fruit. These compounds contribute to mangosteen's antioxidant, anti-inflammatory, antimicrobial, and potential anti-cancer properties. Research on mangosteen is moderately advanced, with a variety of studies supporting its health benefits, though additional large-scale clinical trials are necessary to robustly establish its efficacy. The available evidence includes randomized controlled trials (RCTs) and systematic reviews, albeit with varying quality, indicating a need for more standardized and rigorous research methodologies in future studies.
Benefits
1. Anti-Inflammatory Effects: A systematic review identified significant anti-inflammatory activity from mangosteen, particularly in conditions like obesity and skin diseases, with evidence showing reduced C-reactive protein (CRP) levels in a pilot RCT. 2. Antioxidant Effects: Studies demonstrate that mangosteen extracts exhibit strong antioxidant properties, helping to mitigate oxidative stress in various models including cancer cell lines. 3. Neuroprotective Effects: Evidence suggests that mangosteen may help manage mood disorders due to its effects on neurobiological pathways. 4. Antimicrobial Activity: Mangosteen rind extracts have displayed potential against pathogens, including antimalarial effects when combined with artemisinin products. These findings are most relevant for populations with inflammatory conditions, where mangosteen’s effects can significantly impact health outcomes.
How it works
Mangosteen xanthones influence biological pathways by inhibiting inflammatory mediators and modulating serotonin receptors. They function through antioxidant mechanisms, effectively scavenging free radicals and reducing oxidative stress. Notably, α- and γ-mangostin target specific receptors in the body such as serotonin type 2A and histamine receptors, showcasing its multifunctional effects across various body systems, particularly in immune modulation and neuroprotection.
Side effects
Clinical studies indicate that mangosteen supplements are generally safe, with no significant adverse effects reported up to 18 oz per day. No common side effects exceeding 5% incidence have been identified, and rare or uncommon side effects are also not documented in the literature. There are limited insights on potential drug interactions, though the observed synergistic effect with artemisinin highlights a need for caution. Individuals with known allergies to mangosteen should avoid its use, and pregnant or breastfeeding women are also advised to consult with healthcare professionals prior to supplementation due to a lack of specific safety data.
Dosage
The minimum effective dose identified for anti-inflammatory effects is 18 oz per day, based on a pilot RCT. While optimal dosages are not definitively established, ranges from 3 to 18 oz per day have been utilized in studies. There are no strict timing recommendations, although consistent daily intake is encouraged. Various forms of mangosteen (juice, extracts, whole rinds) present differing bioactive compound bioavailability, with heating potentially enhancing xanthone yield. There is currently no established upper limit for safe dosage, but doses used in studies have not resulted in adverse effects.
FAQs
Is mangosteen safe to take?
Yes, mangosteen supplements are generally considered safe, but individual reactions and interactions with medications should be monitored.
How should I take mangosteen supplements?
There’s no specific timing recommended, but consistent daily use is advised for best results.
What results can I expect from using mangosteen?
Users may experience anti-inflammatory and antioxidant benefits, potentially leading to lower CRP levels and reduced oxidative stress.
Is mangosteen effective for all health problems?
Mangosteen is not a cure-all; its benefits stem from specific biochemical actions rather than broad, unverified claims.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/19843321/ – This study evaluated the effects of a proprietary mangosteen juice blend on inflammatory biomarkers in obese patients, indicating a significant reduction in CRP levels with the highest dose over an 8-week trial.
- https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00115/full – This review highlights the therapeutic potential of mangosteen pericarp, noting its antioxidant and neuroprotective properties, pointing toward potential benefits for mood and psychotic disorders.
- https://ohiostate.elsevierpure.com/en/publications/structural-characterization-biological-effects-and-synthetic-stud – The article discusses the biological effects and mechanisms of action of mangosteen components, particularly focusing on xanthones and their significance in health.
- https://www.science.gov/topicpages/m/mangosteen+fruit+rind – This source provides insights into the chemical composition of the mangosteen fruit rind, emphasizing its potential health implications and biological effects.
- https://oamjms.eu/index.php/mjms/article/view/8746 – This study assesses the antimicrobial efficacy of mangosteen rind extracts, highlighting potential therapeutic uses, especially in infectious diseases.
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