Progestomend A Phytocrine Proprietary Blend
Also known as: ProgestoMend™, Phytocrine Proprietary Blend, ProgestoMend A Phytocrine Proprietary Blend
Overview
ProgestoMend™ is a proprietary herbal blend formulated to support natural progesterone production and function. It combines various botanical extracts, including Paeonia lactiflora, Ligusticum wallichii, Rehmannia glutinosa, Bupleurum falcatum, Passiflora incarnata, Dioscorea villosa (wild yam), Coleus forskohlii, and Vitex agnus-castus. Marketed by Douglas Laboratories, this 'Phytocrine' blend aims to provide hormone support through adaptogenic and phytoprogestogenic actions. It is intended for individuals seeking hormone balance, particularly women with progesterone-related concerns, and can be used as an adjunct to bioidentical hormone therapy. The blend is delivered in vegetarian capsules, with a recommended dosage of 2-4 capsules daily. While individual herbs have traditional uses and some research, the blend itself lacks direct, independent clinical trials.
Benefits
The primary claimed benefits of ProgestoMend™ include supporting progesterone production and enhancing the responsiveness of progesterone-sensitive tissues, as well as supporting adrenal gland function and overall hormone balance. However, there are no high-quality, independent randomized controlled trials (RCTs) or systematic reviews that directly evaluate these benefits for the proprietary blend itself. While some individual components, such as Vitex agnus-castus (chasteberry), have shown modest benefits in RCTs for menstrual cycle regulation and premenstrual syndrome, these findings cannot be directly extrapolated to the entire blend. The product is primarily targeted at adults, especially women, seeking support for progesterone-related concerns. Due to the lack of specific clinical trials on the blend, effect sizes, clinical significance, and time course of benefits are not established.
How it works
ProgestoMend™ is designed to support progesterone production by influencing progesterone-producing glands, such as the adrenals and ovaries, and by mimicking or enhancing progesterone's effects on target tissues. This is achieved through the inclusion of herbs with purported phytoprogestogenic and adaptogenic properties. The blend is believed to interact with the endocrine system, specifically targeting the hypothalamic-pituitary-adrenal (HPA) axis and reproductive hormone pathways. Individual herbs within the blend contain bioactive compounds, such as paeoniflorin from Paeonia, agnuside from Vitex, and forskolin from Coleus, which have been shown in some studies to influence hormone synthesis or receptor activity. However, the precise molecular targets and mechanisms of action for the combined proprietary blend are not fully established.
Side effects
No specific safety data or adverse event reports from clinical trials on the ProgestoMend™ blend itself are available. The individual herbs within the blend generally have good safety profiles when used appropriately, but mild gastrointestinal upset or allergic reactions are possible. Potential drug interactions exist, particularly with hormone therapies and medications metabolized by liver enzymes, necessitating consultation with a healthcare provider. The blend is contraindicated during pregnancy and nursing, and should not be used with prescription medications without professional medical advice. Safety in pregnant or breastfeeding women has not been established. Due to the lack of clinical trials on the blend, the frequency and severity of common, uncommon, or rare side effects are not documented.
Dosage
The manufacturer recommends a dosage of 2-4 capsules daily. Each capsule contains approximately 720 mg of the proprietary blend, meaning a daily intake would range from 1,440 mg to 2,880 mg. The minimum effective dose and maximum safe dose for the ProgestoMend™ blend have not been established by clinical trials. The timing considerations for dosage are not specified. The product is available in vegetarian capsules. Information regarding absorption factors and required cofactors for optimal efficacy is not available.
FAQs
Is ProgestoMend™ clinically proven?
No independent randomized controlled trials or systematic reviews specifically on the ProgestoMend™ proprietary blend have been found to date. Evidence is based on individual herbs.
Is it safe to take ProgestoMend™ with hormone therapy?
It may be used as an adjunct under professional supervision, but caution is advised due to potential interactions. Always consult a healthcare provider before combining.
How long does it take to see effects from ProgestoMend™?
The time course for experiencing benefits from ProgestoMend™ has not been established due to the lack of specific clinical trials on the blend.
Can men use ProgestoMend™?
While the product supports progesterone production, which is present in both genders, its primary marketing is toward women. Consultation with a healthcare provider is recommended for men.
Research Sources
- https://www.yourhormones.com/content/ProgestoMend-product-data.pdf – This document provides product data for ProgestoMend, detailing its ingredients, intended uses, and manufacturer claims. It serves as a primary source for understanding the blend's composition and marketing objectives, but does not present independent clinical research.
- https://www.douglaslabs.com/media/22_11_DL_Hormone-HCP_Brochure_FIN.pdf – This brochure from Douglas Laboratories outlines their hormone support products, including ProgestoMend, for healthcare professionals. It describes the blend's components and their purported roles in hormone balance, reflecting the manufacturer's perspective and product positioning.
- https://us.fullscript.com/catalog/products/progestomend-120-vcaps-1/U3ByZWU6OlZhcmlhbnQt73797 – This product listing provides details on ProgestoMend's formulation, dosage, and general information. It confirms the proprietary nature of the blend and the recommended usage, offering practical information about the supplement as marketed to consumers.
- https://www.douglaslabs.com/media/19_03_DL_Hormone_Brochure_FIN-web.pdf – Another brochure from Douglas Laboratories discussing their hormone support line, reinforcing the claims and intended uses of ProgestoMend. It highlights the company's approach to hormonal health through their proprietary blends.
- https://www.yourhormones.com/about-hormone-specific-formulations/ – This page provides general information about the concept of 'hormone-specific formulations,' which is the framework under which ProgestoMend is developed. It explains the rationale behind using targeted herbal blends for hormone support.