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Also known as: Nattokinase, NK, Subtilisin NAT, Fermented Soybean Extract

Overview

Nattokinase is an enzyme derived from natto, a traditional Japanese food made from fermented soybeans. It is known for its fibrinolytic activity, meaning it can break down blood clots. As a dietary supplement, nattokinase is often used to support cardiovascular health by promoting healthy blood flow and blood pressure. It is available in capsule and tablet form. While research on nattokinase is promising, more comprehensive studies are needed to fully understand its effects and optimal usage. It is often included in circulation support supplements due to its potential benefits for vascular health. Nattokinase is generally considered safe, but caution is advised for individuals with bleeding disorders or those taking anticoagulant medications.

Benefits

Nattokinase has shown potential in improving blood flow and reducing blood pressure. Some studies suggest it can reduce systolic blood pressure by approximately 5-10 mmHg. Its fibrinolytic properties may help prevent blood clot formation, reducing the risk of cardiovascular events. Additionally, nattokinase may have anti-inflammatory effects, contributing to overall cardiovascular health. These benefits are primarily observed in individuals with cardiovascular risk factors. The evidence supporting these benefits is moderate, with ongoing research aimed at further validating these findings and determining optimal dosages for different populations.

How it works

Nattokinase primarily works by enhancing fibrinolysis, the process of breaking down fibrin, a protein involved in blood clot formation. It directly degrades fibrin and also increases the production of plasmin, an enzyme that breaks down fibrin. This action helps to improve blood flow and reduce the risk of blood clots. Additionally, nattokinase may influence blood pressure by inhibiting angiotensin-converting enzyme (ACE), similar to some blood pressure medications. Its effects are primarily focused on the cardiovascular system, promoting healthy vascular function.

Side effects

Nattokinase is generally considered safe for most people when taken as directed. Common side effects may include mild gastrointestinal upset. Uncommon side effects could involve allergic reactions in sensitive individuals. The most significant concern is an increased risk of bleeding, especially in individuals with bleeding disorders or those taking anticoagulant or antiplatelet medications. It is contraindicated in pregnancy and breastfeeding due to the lack of safety data. Caution is advised before surgery, and nattokinase should be discontinued at least one week prior to any surgical procedure to minimize bleeding risks. Individuals should consult with their healthcare provider before taking nattokinase, particularly if they have underlying health conditions or are taking other medications.

Dosage

The typical dosage of nattokinase ranges from 100 to 200 mg per day, often taken in one or two divided doses. It is best taken with meals to minimize potential gastrointestinal side effects. While there is no established maximum safe dose, exceeding recommended dosages is not advised due to the potential for increased bleeding risk. Capsules or tablets are the most common forms. Absorption is generally good, but consistent daily intake is recommended to maintain its effects. Consult product labeling for specific dosage instructions and recommendations.

FAQs

Is nattokinase safe to take with blood thinners?

Nattokinase can increase the risk of bleeding, so it should be used with caution if you are taking blood thinners like warfarin or aspirin. Consult your doctor before combining them.

How long does it take to see the benefits of nattokinase?

Some people may notice improvements in blood pressure and circulation within a few weeks, while others may require several months of consistent use to experience noticeable benefits.

Can nattokinase replace my blood pressure medication?

Nattokinase should not be used as a replacement for prescribed blood pressure medication. It may be used as a complementary therapy, but always consult with your healthcare provider.

Are there any food interactions with nattokinase?

Nattokinase is derived from fermented soybeans, so individuals with soy allergies should avoid it. Taking it with meals may help reduce gastrointestinal side effects.

Who should avoid taking nattokinase?

Pregnant or breastfeeding women, individuals with bleeding disorders, and those scheduled for surgery should avoid nattokinase unless specifically advised by their healthcare provider.

Research Sources

https://www.ugc.gov.in/e-book/Academic%20and%20Research%20Book_WEB.pdf – This source is a general academic resource and does not specifically address nattokinase. It may provide background information on research methodologies and academic writing, but it does not offer specific data or findings related to the supplement's efficacy or safety.